ID   EZRA_STRP1              Reviewed;         574 AA.
AC   Q9A0K9; Q48ZP6;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   OrderedLocusNames=SPy_0728, M5005_Spy0554;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; AE004092; AAK33678.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51172.1; -; Genomic_DNA.
DR   RefSeq; NP_268957.1; NC_002737.2.
DR   AlphaFoldDB; Q9A0K9; -.
DR   SMR; Q9A0K9; -.
DR   STRING; 1314.HKU360_00565; -.
DR   PaxDb; Q9A0K9; -.
DR   EnsemblBacteria; AAK33678; AAK33678; SPy_0728.
DR   KEGG; spy:SPy_0728; -.
DR   KEGG; spz:M5005_Spy0554; -.
DR   PATRIC; fig|160490.10.peg.620; -.
DR   HOGENOM; CLU_034079_2_0_9; -.
DR   OMA; FRSQNHI; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..574
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_0000172891"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        8..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        27..574
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          102..141
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          274..350
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          459..520
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   574 AA;  66120 MW;  91FF87736186B827 CRC64;
     MSSGIILLIV AIVLLVIIAY LVGVIIRKRN DSLITSLEER KQALFALPVN DEIEEVKSLH
     LIGQSQTSFR EWNQKWVDLT VNSFADIENH IFEAENLNDT FNFIRAKHEI NSVESQLNLV
     EEDIASIREA LNILKEQEEK NSARVTHALD LYEKLQASIS ENEDNFGSTM PEIDKQMKNI
     ETEFSQFVAL NSSGDPVEAS EVLDRAEEHT IALGQITEQI PAIVAKLEDD FPDQLDDLET
     GYRRLLEENY HFPEKNIEAR FQEIRESIRA NSSELVTLDL DRAREENTHI QERIDSLYEV
     FEREIAAYKV AAKNSKMLPR YLEHVKRNNE QLKDEIARLS RKYILSETES LTVKAFEKDI
     KEIEDSTLAV AEQFGLQEKP FSELQVTFER SIKTLTNVES GQMDVFAAVK DIEKIESQAR
     HNLDVYVTQL HMIKRYMEKR HLPGIPQDFL SAFFTTSSQL EALMDELSRG RINIEAVSRL
     SEVATVAIAN LEDLTYQVVQ NATLTEQLLQ YSNRYRSFEA GVQSSFEHAL RLFEVENDYQ
     ASFDEISYAL ETVEPGVTDR FVNSYEKTRE HIRF