ID   EZRA_STRSV              Reviewed;         574 AA.
AC   A3CMA0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=SSA_0879;
OS   Streptococcus sanguinis (strain SK36).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=388919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK36;
RX   PubMed=17277061; DOI=10.1128/jb.01808-06;
RA   Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA   Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA   Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT   "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL   J. Bacteriol. 189:3166-3175(2007).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00728};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00728}.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; CP000387; ABN44305.1; -; Genomic_DNA.
DR   RefSeq; WP_011836769.1; NC_009009.1.
DR   RefSeq; YP_001034855.1; NC_009009.1.
DR   AlphaFoldDB; A3CMA0; -.
DR   SMR; A3CMA0; -.
DR   STRING; 388919.SSA_0879; -.
DR   EnsemblBacteria; ABN44305; ABN44305; SSA_0879.
DR   KEGG; ssa:SSA_0879; -.
DR   PATRIC; fig|388919.9.peg.840; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_2_0_9; -.
DR   OMA; FRSQNHI; -.
DR   OrthoDB; 670472at2; -.
DR   Proteomes; UP000002148; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..574
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_1000045914"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        8..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        27..574
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          26..47
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          105..189
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          258..346
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          375..415
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          455..494
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   574 AA;  65961 MW;  B12606BB692D9295 CRC64;
     MSIGLVILVA VVALLLVVGY GTAVLMRKRN EALLQNLEER KEALYNLPVN DEVEEVKNMH
     LIGQSQVAFR EWNQKWVDLS LNSFADIENN LFEAEGYNNS FRFIKAKHAI GNIESQIDLI
     EEDIKMIRAA LEDLKEQESK NSGRVLHALD LFEKLQTQVA ENADSYGQAL AEIEKQLENI
     QSEFSQFVTL NSSGDPVEAA EILDKAEDHI LALTHIVEKV PAIVEELTVK LPDQLEDLES
     GHRKLLESGY HFIETDIESR FQQLHASLKR NEANISALEL DNAEYENEQA QEEINALYEI
     FTREIEAHKV VEKLIKNLPS YLAHTKENNQ QLQKEIERLS QTFLISDTET SHVKELQAEL
     SAQEDVVLSA VEDSSETKQA YSVVQEELEA IQERLKEIED EQISLGEALA EIEKDDANAR
     QKVNIYANKL HTIKRYMEKR NLPGIPDSFL EIFFSTSNNI EELVKELEAT RVNIESVNRW
     LEILGNDMEQ LEEETYRIVQ DATLTEQLLQ YSNRYRSFDD NVQAAFNKSL YVFEHDYDYA
     QSLEIISKAL DLVEPGVTER FVTSYEKTRE NIRF