EZRA_STRSY
ID EZRA_STRSY Reviewed; 574 AA.
AC A4VWI6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=SSU05_1509;
OS Streptococcus suis (strain 05ZYH33).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=391295;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05ZYH33;
RX PubMed=17375201; DOI=10.1371/journal.pone.0000315;
RA Chen C., Tang J., Dong W., Wang C., Feng Y., Wang J., Zheng F., Pan X.,
RA Liu D., Li M., Song Y., Zhu X., Sun H., Feng T., Guo Z., Ju A., Ge J.,
RA Dong Y., Sun W., Jiang Y., Wang J., Yan J., Yang H., Wang X., Gao G.F.,
RA Yang R., Wang J., Yu J.;
RT "A glimpse of streptococcal toxic shock syndrome from comparative genomics
RT of S. suis 2 Chinese isolates.";
RL PLoS ONE 2:E315-E315(2007).
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00728};
CC Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00728}.
CC Note=Colocalized with FtsZ to the nascent septal site.
CC {ECO:0000255|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00728}.
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DR EMBL; CP000407; ABP90475.1; -; Genomic_DNA.
DR AlphaFoldDB; A4VWI6; -.
DR SMR; A4VWI6; -.
DR STRING; 391295.SSU05_1509; -.
DR EnsemblBacteria; ABP90475; ABP90475; SSU05_1509.
DR KEGG; ssu:SSU05_1509; -.
DR eggNOG; COG4477; Bacteria.
DR HOGENOM; CLU_034079_2_0_9; -.
DR OMA; FRSQNHI; -.
DR Proteomes; UP000000243; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT CHAIN 1..574
FT /note="Septation ring formation regulator EzrA"
FT /id="PRO_1000045915"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT TRANSMEM 8..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT TOPO_DOM 27..574
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT COILED 105..189
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ SEQUENCE 574 AA; 66430 MW; 708F29CCDBC6B0AB CRC64;
MPTGTIILIV SIVIILIIAY VACLIVRKRN DNLLVALEER KEELFNLPVN EEVETVKALH
LIGQSQVSFR EWNQKWVDLS LNSFADIENH IFEAEGYNNA FRFVSAKNAI DSIDSQIDLI
EEDIASIRQG LMELKEQEEK NSGRVKHALN LFDSLQEAVR ENPDSYGETL SELEKQLKNI
EVEFSEFVML NSSGDPIEAS EILDKTEEHM IALNQIMDRI PSLIERVTKD FPEQLEDLES
GYRKLVEQNY LFTEANIESQ FQNIRVSIRE NTALIVSFDL DAAEAENEGI QAKIDHLYKV
FNREIEANKE AVKISKNLPK FLEHVVQNTQ LLDEESQRLN ATYLLADSKL SRINQLKARL
ESIEIVVTES VEDIENPQVA YSILEERLDH SLASLKEIEE EQLVLADYLK SQELSENTAR
KKATLYINKL HTLKRYMEKR NLPGIPAEFL TNFFRTSDHV EALIAELDYK RINIEVVNRL
LENATYDMNQ LEELAYLIVQ NATLTEQLLQ YSNRYRSFDE SVQKAFNRSL SIFEKDFDYQ
AAFEEISFAL ETVEPGVTER FVRSYEKTRE AIRY