ID   EZRA_STRU0              Reviewed;         574 AA.
AC   B9DRR4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=SUB0650;
OS   Streptococcus uberis (strain ATCC BAA-854 / 0140J).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=218495;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-854 / 0140J;
RX   PubMed=19175920; DOI=10.1186/1471-2164-10-54;
RA   Ward P.N., Holden M.T.G., Leigh J.A., Lennard N., Bignell A., Barron A.,
RA   Clark L., Quail M.A., Woodward J., Barrell B.G., Egan S.A., Field T.R.,
RA   Maskell D., Kehoe M., Dowson C.G., Chanter N., Whatmore A.M., Bentley S.D.,
RA   Parkhill J.;
RT   "Evidence for niche adaptation in the genome of the bovine pathogen
RT   Streptococcus uberis.";
RL   BMC Genomics 10:54-54(2009).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00728};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00728}.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; AM946015; CAR41505.1; -; Genomic_DNA.
DR   RefSeq; WP_012658169.1; NC_012004.1.
DR   AlphaFoldDB; B9DRR4; -.
DR   SMR; B9DRR4; -.
DR   STRING; 218495.SUB0650; -.
DR   EnsemblBacteria; CAR41505; CAR41505; SUB0650.
DR   KEGG; sub:SUB0650; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_2_0_9; -.
DR   OMA; FRSQNHI; -.
DR   OrthoDB; 670472at2; -.
DR   Proteomes; UP000000449; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..574
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_1000148074"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        8..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        27..574
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          102..140
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          243..379
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          459..520
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   574 AA;  66465 MW;  8FBAF1EFC456D42E CRC64;
     MSSGIILLIV AIVLLVIIAY LIGVIIRKRN DSMIGTLEDR KQHLFGLPVN EEIEEVKELH
     LIGQSQTSFR EWNQKWVDLT LNSFADIENH LFEAEKYNDT FNFIRAKHEI NNVESQLNLV
     EEDITSIREA LSILKEQEEK NSARVTHALD LYEKLQSSVA ENDSHFGTTK PEIEKQMKNI
     ETEFSQFVTL NSSGDPVEAS EVLDRAEEHT IALGQITEQI PAIVAKLEDE FPDQLDDLES
     GYRRLLEDNY HFAENNIEEK FQEIREAIRS NASELVSLDL DRAREENSHI QERIDNMYAL
     FEHEIKAFKV SAKHSKIIPS YLEHAKSNND KLKEEMTRLS RKYILNENQA STVQGFEKEI
     EDVEKNVLEL AKDFKGQEIP YSELQVVFEK NLKTLSAVES GQMEVFESIK NIENIEEDAR
     KEADLYVTQL HMIKRFMEKR HLPGIPQDYL NVFFTTSTQL EALMDELSKG KINIEAVSRL
     RDVASASIAN LEDYTYQVVE NATLTEQLLQ YSNRYRSFEA GVQNSFEIAM HLFEVEYDYQ
     ASFDEISYAL ETVEPGVTDR FVSSYERTRE HIRF