F102A_HUMAN
ID F102A_HUMAN Reviewed; 384 AA.
AC Q5T9C2; A2A329; Q8TEL4;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Protein FAM102A;
DE AltName: Full=Early estrogen-induced gene 1 protein;
GN Name=FAM102A; Synonyms=C9orf132, EEIG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 177-384 (ISOFORM 2).
RC TISSUE=Spleen;
RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION.
RX PubMed=14605097; DOI=10.1210/me.2003-0202;
RA Wang D.Y., Fulthorpe R., Liss S.N., Edwards E.A.;
RT "Identification of estrogen-responsive genes by complementary
RT deoxyribonucleic acid microarray and characterization of a novel early
RT estrogen-induced gene: EEIG1.";
RL Mol. Endocrinol. 18:402-411(2004).
CC -!- FUNCTION: May play a role in estrogen action.
CC {ECO:0000269|PubMed:14605097}.
CC -!- INTERACTION:
CC Q5T9C2; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-10246318, EBI-744099;
CC Q5T9C2; Q6FGM0: SH3GL1; NbExp=3; IntAct=EBI-10246318, EBI-10173690;
CC Q5T9C2; Q86WV1: SKAP1; NbExp=4; IntAct=EBI-10246318, EBI-2477305;
CC Q5T9C2-3; P56945: BCAR1; NbExp=3; IntAct=EBI-11980989, EBI-702093;
CC Q5T9C2-3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11980989, EBI-3867333;
CC Q5T9C2-3; Q14511-2: NEDD9; NbExp=3; IntAct=EBI-11980989, EBI-11746523;
CC Q5T9C2-3; Q99471: PFDN5; NbExp=3; IntAct=EBI-11980989, EBI-357275;
CC Q5T9C2-3; Q99961: SH3GL1; NbExp=3; IntAct=EBI-11980989, EBI-697911;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5T9C2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T9C2-2; Sequence=VSP_021744;
CC Name=3;
CC IsoId=Q5T9C2-3; Sequence=VSP_043857;
CC -!- INDUCTION: By 17-beta-estradiol but also by a group of natural and
CC synthetic estrogens as well as by estrogenic environmental compounds.
CC Repressed by the antiestrogen 4-hydroxy-tamoxifen.
CC -!- SIMILARITY: Belongs to the FAM102 family. {ECO:0000305}.
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DR EMBL; AL157935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137087; AAI37088.1; -; mRNA.
DR EMBL; BC137088; AAI37089.1; -; mRNA.
DR EMBL; AK074108; BAB84934.1; -; mRNA.
DR CCDS; CCDS35150.1; -. [Q5T9C2-1]
DR CCDS; CCDS6888.1; -. [Q5T9C2-3]
DR RefSeq; NP_001030331.1; NM_001035254.2. [Q5T9C2-1]
DR RefSeq; NP_976050.1; NM_203305.2. [Q5T9C2-3]
DR AlphaFoldDB; Q5T9C2; -.
DR BioGRID; 134377; 154.
DR IntAct; Q5T9C2; 10.
DR STRING; 9606.ENSP00000362187; -.
DR GlyGen; Q5T9C2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5T9C2; -.
DR PhosphoSitePlus; Q5T9C2; -.
DR BioMuta; FAM102A; -.
DR DMDM; 118572304; -.
DR EPD; Q5T9C2; -.
DR jPOST; Q5T9C2; -.
DR MassIVE; Q5T9C2; -.
DR MaxQB; Q5T9C2; -.
DR PaxDb; Q5T9C2; -.
DR PeptideAtlas; Q5T9C2; -.
DR PRIDE; Q5T9C2; -.
DR ProteomicsDB; 64787; -. [Q5T9C2-1]
DR ProteomicsDB; 64788; -. [Q5T9C2-2]
DR ProteomicsDB; 64789; -. [Q5T9C2-3]
DR Antibodypedia; 51717; 12 antibodies from 9 providers.
DR DNASU; 399665; -.
DR Ensembl; ENST00000373084.8; ENSP00000362176.4; ENSG00000167106.12. [Q5T9C2-3]
DR Ensembl; ENST00000373095.6; ENSP00000362187.1; ENSG00000167106.12. [Q5T9C2-1]
DR GeneID; 399665; -.
DR KEGG; hsa:399665; -.
DR MANE-Select; ENST00000373095.6; ENSP00000362187.1; NM_001035254.3; NP_001030331.1.
DR UCSC; uc004bsw.2; human. [Q5T9C2-1]
DR CTD; 399665; -.
DR DisGeNET; 399665; -.
DR GeneCards; FAM102A; -.
DR HGNC; HGNC:31419; FAM102A.
DR HPA; ENSG00000167106; Low tissue specificity.
DR MIM; 610891; gene.
DR neXtProt; NX_Q5T9C2; -.
DR OpenTargets; ENSG00000167106; -.
DR PharmGKB; PA142671784; -.
DR VEuPathDB; HostDB:ENSG00000167106; -.
DR eggNOG; ENOG502QRRN; Eukaryota.
DR GeneTree; ENSGT00940000156811; -.
DR HOGENOM; CLU_024948_1_1_1; -.
DR InParanoid; Q5T9C2; -.
DR OMA; FADINHT; -.
DR OrthoDB; 725501at2759; -.
DR PhylomeDB; Q5T9C2; -.
DR TreeFam; TF320966; -.
DR PathwayCommons; Q5T9C2; -.
DR SignaLink; Q5T9C2; -.
DR BioGRID-ORCS; 399665; 16 hits in 1082 CRISPR screens.
DR ChiTaRS; FAM102A; human.
DR GenomeRNAi; 399665; -.
DR Pharos; Q5T9C2; Tdark.
DR PRO; PR:Q5T9C2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5T9C2; protein.
DR Bgee; ENSG00000167106; Expressed in gall bladder and 189 other tissues.
DR Genevisible; Q5T9C2; HS.
DR InterPro; IPR039931; FAM102-like.
DR InterPro; IPR019448; NT-C2.
DR PANTHER; PTHR21456; PTHR21456; 1.
DR Pfam; PF10358; NT-C2; 1.
DR PROSITE; PS51840; C2_NT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..384
FT /note="Protein FAM102A"
FT /id="PRO_0000261634"
FT DOMAIN 2..145
FT /note="C2 NT-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01186"
FT REGION 173..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..142
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043857"
FT VAR_SEQ 371..384
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_021744"
SQ SEQUENCE 384 AA; 41785 MW; 330218BC18A0EA8C CRC64;
MAFLMKKKKF KFQTTFTLEE LTAVPFVNGV LFCKVRLLDG GDFVSLSSRE EVQENCVRWR
KRFTFVCKMS ANPATGLLDP CVFRVSVRKE LKGGKAYSKL GFADLNLAEF AGSGSTVRCC
LLEGYDTKNT RQDNSILKVT IGMFLLSGDP CFKTPPSTAK SISIPGQDSS LQLTCKGGGT
SSGGSSTNSL TGSRPPKARP TILSSGLPEE PDQNLSSPEE VFHSGHSRNS SYASQQSKIS
GYSTEHSRSS SLSDLTHRRN TSTSSSASGG LGMTVEGPEG SEREHRPPEK PPRPPRPLHL
SDRSFRRKKD SVESHPTWVD DTRIDADAIV EKIVQSQDFT DGSNTEDSNL RLFVSRDGSA
TLSGIQLATR VSSGVYEPVV IESH
