F102A_MOUSE
ID F102A_MOUSE Reviewed; 392 AA.
AC Q78T81; Q8K2K5;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Protein FAM102A;
GN Name=Fam102a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Cerebellum, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-392.
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in estrogen action. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FAM102 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH31157.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK049032; BAC33519.1; -; mRNA.
DR EMBL; AK157331; BAE34050.1; -; mRNA.
DR EMBL; AK157490; BAE34101.1; -; mRNA.
DR EMBL; AK170536; BAE41864.1; -; mRNA.
DR EMBL; AK170847; BAE42070.1; -; mRNA.
DR EMBL; AK170951; BAE42135.1; -; mRNA.
DR EMBL; AK172536; BAE43056.1; -; mRNA.
DR EMBL; BC031157; AAH31157.1; ALT_INIT; mRNA.
DR CCDS; CCDS15917.1; -.
DR RefSeq; NP_705788.1; NM_153560.4.
DR AlphaFoldDB; Q78T81; -.
DR SMR; Q78T81; -.
DR STRING; 10090.ENSMUSP00000044731; -.
DR iPTMnet; Q78T81; -.
DR PhosphoSitePlus; Q78T81; -.
DR EPD; Q78T81; -.
DR MaxQB; Q78T81; -.
DR PaxDb; Q78T81; -.
DR PRIDE; Q78T81; -.
DR ProteomicsDB; 275794; -.
DR Antibodypedia; 51717; 12 antibodies from 9 providers.
DR DNASU; 98952; -.
DR Ensembl; ENSMUST00000048375; ENSMUSP00000044731; ENSMUSG00000039157.
DR GeneID; 98952; -.
DR KEGG; mmu:98952; -.
DR UCSC; uc008jfs.1; mouse.
DR CTD; 399665; -.
DR MGI; MGI:2138935; Fam102a.
DR VEuPathDB; HostDB:ENSMUSG00000039157; -.
DR eggNOG; ENOG502QRRN; Eukaryota.
DR GeneTree; ENSGT00940000156811; -.
DR HOGENOM; CLU_024948_1_1_1; -.
DR InParanoid; Q78T81; -.
DR OMA; WRKKFTF; -.
DR OrthoDB; 725501at2759; -.
DR PhylomeDB; Q78T81; -.
DR TreeFam; TF320966; -.
DR BioGRID-ORCS; 98952; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Fam102a; mouse.
DR PRO; PR:Q78T81; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q78T81; protein.
DR Bgee; ENSMUSG00000039157; Expressed in dentate gyrus of hippocampal formation granule cell and 260 other tissues.
DR ExpressionAtlas; Q78T81; baseline and differential.
DR Genevisible; Q78T81; MM.
DR InterPro; IPR039931; FAM102-like.
DR InterPro; IPR019448; NT-C2.
DR PANTHER; PTHR21456; PTHR21456; 1.
DR Pfam; PF10358; NT-C2; 1.
DR PROSITE; PS51840; C2_NT; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..392
FT /note="Protein FAM102A"
FT /id="PRO_0000261635"
FT DOMAIN 2..145
FT /note="C2 NT-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01186"
FT REGION 173..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 392 AA; 42830 MW; F4DB10650412E91C CRC64;
MAFLMKKKKF KFQTTFTLEE LTAVPFVNGV LFCKVRLLDG GDFVSLSSRE EVQENCVRWR
KRFTFVCKMS ANPATGLLDP CIFRVSVRKE LKGGKAYSKL GFTDLNLAEF AGSGSTVRCC
LLEGYDTKNT RQDNSILKVT IGMFLLSGDP CFKTPPSTAK SISIPGQDSS LQLTCKGGGT
SSGGSSSTNS LTGSRPPKTR PTILGSGLPE EPDQSLSSPE EVFHSGHSRN SSYASQQSKL
SGYSTEHSRS SSLSDLTHRR NTSTSSSASG GLSMAVEGPE GMEREHRPSE KPPRPPEKPP
RPPRPLHLSD RSFRRKKDSV ESHPTWVDDT RIDADDIVEK IMQSQDFTDG SNTEDSNLRL
FVSRDGSTTL SGIQLGNRVS SGVYEPVVIE SH
