F102B_HUMAN
ID F102B_HUMAN Reviewed; 360 AA.
AC Q5T8I3; A1L1A1; B0QZ46; B0QZ47; Q68DH7;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Protein FAM102B;
GN Name=FAM102B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 118-360 (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320 AND SER-321, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-228; SER-276; SER-288;
RP SER-320 AND SER-350, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5T8I3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T8I3-2; Sequence=VSP_034833;
CC -!- SIMILARITY: Belongs to the FAM102 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI27899.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI40864.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI40866.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI50531.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL160171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471122; EAW56323.1; -; Genomic_DNA.
DR EMBL; BC127898; AAI27899.2; ALT_INIT; mRNA.
DR EMBL; BC140863; AAI40864.1; ALT_INIT; mRNA.
DR EMBL; BC140865; AAI40866.1; ALT_INIT; mRNA.
DR EMBL; BC150530; AAI50531.1; ALT_INIT; mRNA.
DR EMBL; CR749397; CAH18243.1; -; mRNA.
DR CCDS; CCDS30786.2; -. [Q5T8I3-1]
DR RefSeq; NP_001010883.2; NM_001010883.2. [Q5T8I3-1]
DR AlphaFoldDB; Q5T8I3; -.
DR BioGRID; 129914; 16.
DR IntAct; Q5T8I3; 6.
DR STRING; 9606.ENSP00000359052; -.
DR GlyGen; Q5T8I3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5T8I3; -.
DR PhosphoSitePlus; Q5T8I3; -.
DR BioMuta; FAM102B; -.
DR DMDM; 205831290; -.
DR EPD; Q5T8I3; -.
DR jPOST; Q5T8I3; -.
DR MassIVE; Q5T8I3; -.
DR MaxQB; Q5T8I3; -.
DR PaxDb; Q5T8I3; -.
DR PeptideAtlas; Q5T8I3; -.
DR PRIDE; Q5T8I3; -.
DR ProteomicsDB; 64733; -. [Q5T8I3-1]
DR ProteomicsDB; 64734; -. [Q5T8I3-2]
DR Antibodypedia; 33730; 86 antibodies from 16 providers.
DR DNASU; 284611; -.
DR Ensembl; ENST00000370035.8; ENSP00000359052.3; ENSG00000162636.16. [Q5T8I3-1]
DR Ensembl; ENST00000405454.1; ENSP00000386084.1; ENSG00000162636.16. [Q5T8I3-2]
DR GeneID; 284611; -.
DR KEGG; hsa:284611; -.
DR MANE-Select; ENST00000370035.8; ENSP00000359052.3; NM_001010883.3; NP_001010883.2.
DR UCSC; uc010ouy.3; human. [Q5T8I3-1]
DR CTD; 284611; -.
DR DisGeNET; 284611; -.
DR GeneCards; FAM102B; -.
DR HGNC; HGNC:27637; FAM102B.
DR HPA; ENSG00000162636; Low tissue specificity.
DR neXtProt; NX_Q5T8I3; -.
DR OpenTargets; ENSG00000162636; -.
DR PharmGKB; PA142671785; -.
DR VEuPathDB; HostDB:ENSG00000162636; -.
DR eggNOG; ENOG502QRRN; Eukaryota.
DR GeneTree; ENSGT00940000156132; -.
DR HOGENOM; CLU_024948_1_1_1; -.
DR InParanoid; Q5T8I3; -.
DR OMA; LFMCKIS; -.
DR OrthoDB; 725501at2759; -.
DR PhylomeDB; Q5T8I3; -.
DR TreeFam; TF320966; -.
DR PathwayCommons; Q5T8I3; -.
DR SignaLink; Q5T8I3; -.
DR BioGRID-ORCS; 284611; 18 hits in 1085 CRISPR screens.
DR ChiTaRS; FAM102B; human.
DR GenomeRNAi; 284611; -.
DR Pharos; Q5T8I3; Tdark.
DR PRO; PR:Q5T8I3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T8I3; protein.
DR Bgee; ENSG00000162636; Expressed in dorsal root ganglion and 183 other tissues.
DR Genevisible; Q5T8I3; HS.
DR InterPro; IPR039931; FAM102-like.
DR InterPro; IPR019448; NT-C2.
DR PANTHER; PTHR21456; PTHR21456; 1.
DR Pfam; PF10358; NT-C2; 1.
DR PROSITE; PS51840; C2_NT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..360
FT /note="Protein FAM102B"
FT /id="PRO_0000236180"
FT DOMAIN 1..142
FT /note="C2 NT-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01186"
FT MOD_RES 228
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 276
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 288
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 320
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 321
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 350
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 347..360
FT /note="RVGSGAYEQVVIKR -> SALEAPSLL (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_034833"
SQ SEQUENCE 360 AA; 39308 MW; 6B10349E4B755FE4 CRC64;
MMKKKKFKFK VDFELEELSS VPFVNGVLFC KMRLLDGGSF TAESSREVVQ ANCVRWRKKF
SFMCKMSASA ATGILDPCIY RVSVRKELKG GKAYAKLGFA DLNLAEFAGS GNTTRRCLLE
GYDTKNTRQD NSILKVLISM QLMSGDPCFK TPPSTSMSIP IAGESESLQE DRKGGETLKV
HLGIADLSAK SASVPDELGA CGHSRTSSYA SQQSKVSGYS TCHSRSSSFS ELCHRRNTSV
GSTSTGVESI LEPCDEIEQK IAEPNLDTAD KEDTASEKLS RCPVKQDSVE SQLKRVDDTR
VDADDIVEKI LQSQDFSLDS SAEEEGLRLF VGPGGSTTFG SHHLPNRVGS GAYEQVVIKR
