F104A_HUMAN
ID F104A_HUMAN Reviewed; 186 AA.
AC Q969W3; B4E339;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Protein FAM104A;
GN Name=FAM104A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Teratocarcinoma, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-186 (ISOFORM 1).
RC TISSUE=Brain, and Rhabdomyosarcoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 57-186 (ISOFORM 2).
RX PubMed=9417904; DOI=10.1006/geno.1997.5044;
RA Reddy P.H., Stockburger E., Gillevet P., Tagle D.A.;
RT "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human
RT brain derived by the oligo capture method.";
RL Genomics 46:174-182(1997).
RN [6]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-4, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- INTERACTION:
CC Q969W3; V9HW80: HEL-S-70; NbExp=3; IntAct=EBI-10281506, EBI-10175326;
CC Q969W3; P17612: PRKACA; NbExp=3; IntAct=EBI-10281506, EBI-476586;
CC Q969W3; P50454: SERPINH1; NbExp=3; IntAct=EBI-10281506, EBI-350723;
CC Q969W3; P37173: TGFBR2; NbExp=3; IntAct=EBI-10281506, EBI-296151;
CC Q969W3; Q14CS0: UBXN2B; NbExp=3; IntAct=EBI-10281506, EBI-1993619;
CC Q969W3; P55072: VCP; NbExp=6; IntAct=EBI-10281506, EBI-355164;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q969W3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q969W3-2; Sequence=VSP_039868;
CC -!- SIMILARITY: Belongs to the FAM104 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH11054.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH25238.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB55292.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC11183.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK027681; BAB55292.1; ALT_INIT; mRNA.
DR EMBL; AK074755; BAC11183.1; ALT_INIT; mRNA.
DR EMBL; AK304556; BAG65351.1; -; mRNA.
DR EMBL; AC097641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471099; EAW89116.1; -; Genomic_DNA.
DR EMBL; BC011054; AAH11054.1; ALT_INIT; mRNA.
DR EMBL; BC025238; AAH25238.1; ALT_INIT; mRNA.
DR EMBL; U92989; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS11693.2; -. [Q969W3-1]
DR CCDS; CCDS45766.1; -. [Q969W3-2]
DR RefSeq; NP_001092302.1; NM_001098832.1. [Q969W3-2]
DR RefSeq; NP_001276339.1; NM_001289410.1.
DR RefSeq; NP_001276340.1; NM_001289411.1.
DR RefSeq; NP_001276341.1; NM_001289412.1.
DR RefSeq; NP_116226.2; NM_032837.2. [Q969W3-1]
DR AlphaFoldDB; Q969W3; -.
DR BioGRID; 124358; 6.
DR IntAct; Q969W3; 7.
DR iPTMnet; Q969W3; -.
DR PhosphoSitePlus; Q969W3; -.
DR BioMuta; FAM104A; -.
DR DMDM; 308153443; -.
DR EPD; Q969W3; -.
DR jPOST; Q969W3; -.
DR MassIVE; Q969W3; -.
DR MaxQB; Q969W3; -.
DR PeptideAtlas; Q969W3; -.
DR PRIDE; Q969W3; -.
DR ProteomicsDB; 75860; -. [Q969W3-1]
DR ProteomicsDB; 75861; -. [Q969W3-2]
DR Antibodypedia; 19372; 10 antibodies from 6 providers.
DR DNASU; 84923; -.
DR Ensembl; ENST00000403627.7; ENSP00000384648.3; ENSG00000133193.13. [Q969W3-1]
DR Ensembl; ENST00000405159.8; ENSP00000384832.3; ENSG00000133193.13. [Q969W3-2]
DR GeneID; 84923; -.
DR KEGG; hsa:84923; -.
DR MANE-Select; ENST00000405159.8; ENSP00000384832.3; NM_001098832.2; NP_001092302.1. [Q969W3-2]
DR UCSC; uc002jji.5; human. [Q969W3-1]
DR CTD; 84923; -.
DR DisGeNET; 84923; -.
DR GeneCards; FAM104A; -.
DR HGNC; HGNC:25918; FAM104A.
DR HPA; ENSG00000133193; Group enriched (bone marrow, testis).
DR neXtProt; NX_Q969W3; -.
DR OpenTargets; ENSG00000133193; -.
DR PharmGKB; PA142671787; -.
DR VEuPathDB; HostDB:ENSG00000133193; -.
DR GeneTree; ENSGT00940000163640; -.
DR HOGENOM; CLU_117251_0_0_1; -.
DR InParanoid; Q969W3; -.
DR OMA; PVTKNCK; -.
DR OrthoDB; 1629457at2759; -.
DR PhylomeDB; Q969W3; -.
DR TreeFam; TF335777; -.
DR PathwayCommons; Q969W3; -.
DR SignaLink; Q969W3; -.
DR BioGRID-ORCS; 84923; 20 hits in 1081 CRISPR screens.
DR ChiTaRS; FAM104A; human.
DR GenomeRNAi; 84923; -.
DR Pharos; Q969W3; Tdark.
DR PRO; PR:Q969W3; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q969W3; protein.
DR Bgee; ENSG00000133193; Expressed in sperm and 186 other tissues.
DR ExpressionAtlas; Q969W3; baseline and differential.
DR Genevisible; Q969W3; HS.
DR InterPro; IPR029222; FAM104.
DR PANTHER; PTHR34763; PTHR34763; 1.
DR Pfam; PF15434; FAM104; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Reference proteome.
FT CHAIN 1..186
FT /note="Protein FAM104A"
FT /id="PRO_0000236182"
FT REGION 1..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 4
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT VAR_SEQ 107
FT /note="E -> ETVPVMRNSKENRLRGNKAFCA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9417904"
FT /id="VSP_039868"
SQ SEQUENCE 186 AA; 19484 MW; BE96E7F6BC18DEB4 CRC64;
MGGRGADAGS SGGTGPTEGY SPPAASTRAA ARAKARGGGR GGRRNTTPSV PSLRGAAPRS
FHPPAAMSER LRPRKRRRNG NEEDNHLPPQ TKRSSRNPVF QDSWDTESSG SDSGGSSSSS
SSSINSPDRA SGPEGSLSQT MAGSSPNTPQ PVPEQSALCQ GLYFHINQTL REAHFHSLQH
RGRPLT
