ID   F107A_PONAB             Reviewed;         144 AA.
AC   Q5NVP3;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Actin-associated protein FAM107A {ECO:0000305};
GN   Name=FAM107A; Synonyms=DRR1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stress-inducible actin-binding protein that plays a role in
CC       synaptic and cognitive functions by modulating actin filamentous (F-
CC       actin) dynamics. Mediates polymerization of globular actin to F-actin.
CC       Also binds to, stabilizes and bundles F-actin. Involved in synaptic
CC       function by regulating neurite outgrowth in an actin-dependent manner
CC       and for the acquisition of hippocampus-dependent cognitive function,
CC       such as learning and long-term memory (By similarity). Plays a role in
CC       the actin and microtubule cytoskeleton organization; negatively
CC       regulates focal adhesion (FA) assembly promoting malignant glial cell
CC       migration in an actin-, microtubule- and MAP1A-dependent manner. Also
CC       involved in neuroblastoma G1/S phase cell cycle progression and cell
CC       proliferation inhibition by stimulating ubiquitination of NF-kappa-B
CC       subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-
CC       dependent manner. May play a role in tumor development (By similarity).
CC       {ECO:0000250|UniProtKB:O95990, ECO:0000250|UniProtKB:Q78TU8}.
CC   -!- SUBUNIT: Interacts with ACTB. Interacts with COMMD1; this interaction
CC       stabilizes COMMD1 in the nucleus. Interacts with MAP1A. Interacts with
CC       PRDX1 (By similarity). Interacts with F-actin (By similarity).
CC       {ECO:0000250|UniProtKB:O95990, ECO:0000250|UniProtKB:Q78TU8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95990}.
CC       Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:O95990}.
CC       Cell junction, focal adhesion {ECO:0000250|UniProtKB:O95990}. Cell
CC       projection, ruffle membrane {ECO:0000250|UniProtKB:O95990}. Synapse
CC       {ECO:0000250|UniProtKB:Q78TU8}. Note=Colocalizes with F-actin and
CC       COMMD1 in the nucleus. Colocalizes with MAP1A along actin stress fibers
CC       and membrane ruffles. {ECO:0000250|UniProtKB:O95990}.
CC   -!- SIMILARITY: Belongs to the FAM107 family. {ECO:0000305}.
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DR   EMBL; CR925969; CAI29620.1; -; mRNA.
DR   RefSeq; NP_001127077.1; NM_001133605.1.
DR   AlphaFoldDB; Q5NVP3; -.
DR   SMR; Q5NVP3; -.
DR   STRING; 9601.ENSPPYP00000015390; -.
DR   GeneID; 100174107; -.
DR   KEGG; pon:100174107; -.
DR   CTD; 11170; -.
DR   eggNOG; ENOG502RZJK; Eukaryota.
DR   HOGENOM; CLU_122902_2_0_1; -.
DR   InParanoid; Q5NVP3; -.
DR   OMA; MNHRRGI; -.
DR   OrthoDB; 1491333at2759; -.
DR   TreeFam; TF325943; -.
DR   Proteomes; UP000001595; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   InterPro; IPR009533; FAM107.
DR   PANTHER; PTHR16768; PTHR16768; 1.
DR   Pfam; PF06625; DUF1151; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell cycle; Cell junction; Cell membrane; Cell projection;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Growth regulation; Membrane; Nucleus;
KW   Reference proteome; Stress response; Synapse.
FT   CHAIN           1..144
FT                   /note="Actin-associated protein FAM107A"
FT                   /id="PRO_0000080015"
FT   COILED          67..94
FT                   /evidence="ECO:0000255"
FT   MOTIF           74..84
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:O95990"
SQ   SEQUENCE   144 AA;  17425 MW;  90D842C723D68A36 CRC64;
     MYSEIQRERA DIGGLMARPE YREWNPELIK PKKLLNPVKA SRSHQELHRE LLMNHRRGLG
     VDSKPELQRV LEHRRRNQLI KKKKEELEAK RLQCPFEQEL LRRQQRLNQL EKPPEKEEDH
     APEFIKVREN LRRIATLTSE ERVL