F107B_HUMAN
ID F107B_HUMAN Reviewed; 131 AA.
AC Q9H098; A8K1P4; D3DRT2; Q5T9K7; Q5T9K8; Q6ZSI4;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Protein FAM107B {ECO:0000305};
GN Name=FAM107B {ECO:0000312|HGNC:HGNC:23726}; Synonyms=C10orf45;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Hippocampus, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lymph, PNS, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H098-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H098-2; Sequence=VSP_037527;
CC -!- SIMILARITY: Belongs to the FAM107 family. {ECO:0000305}.
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DR EMBL; AL136885; CAB66819.1; -; mRNA.
DR EMBL; CR533466; CAG38497.1; -; mRNA.
DR EMBL; AK127413; BAC86966.1; -; mRNA.
DR EMBL; AK289959; BAF82648.1; -; mRNA.
DR EMBL; AL158168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC069544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL157706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471072; EAW86268.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW86269.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW86270.1; -; Genomic_DNA.
DR EMBL; BC004872; AAH04872.1; -; mRNA.
DR EMBL; BC064407; AAH64407.1; -; mRNA.
DR EMBL; BC072452; AAH72452.1; -; mRNA.
DR CCDS; CCDS60486.1; -. [Q9H098-1]
DR CCDS; CCDS7102.1; -. [Q9H098-2]
DR RefSeq; NP_001269624.1; NM_001282695.1. [Q9H098-1]
DR RefSeq; NP_001269625.1; NM_001282696.1. [Q9H098-1]
DR RefSeq; NP_001269626.1; NM_001282697.1. [Q9H098-1]
DR RefSeq; NP_001269627.1; NM_001282698.1. [Q9H098-1]
DR RefSeq; NP_001269628.1; NM_001282699.1. [Q9H098-1]
DR RefSeq; NP_001269629.1; NM_001282700.1. [Q9H098-1]
DR RefSeq; NP_001269630.1; NM_001282701.1. [Q9H098-1]
DR RefSeq; NP_001269631.1; NM_001282702.1. [Q9H098-1]
DR RefSeq; NP_001269632.1; NM_001282703.1. [Q9H098-1]
DR RefSeq; NP_001307664.1; NM_001320735.1. [Q9H098-1]
DR RefSeq; NP_001307665.1; NM_001320736.1. [Q9H098-1]
DR RefSeq; NP_001307666.1; NM_001320737.1. [Q9H098-1]
DR RefSeq; NP_001307667.1; NM_001320738.1. [Q9H098-1]
DR RefSeq; NP_001307668.1; NM_001320739.1. [Q9H098-1]
DR RefSeq; NP_001307669.1; NM_001320740.1. [Q9H098-1]
DR RefSeq; NP_001307670.1; NM_001320741.1.
DR RefSeq; NP_113641.2; NM_031453.3. [Q9H098-2]
DR RefSeq; XP_005252673.1; XM_005252616.3. [Q9H098-1]
DR RefSeq; XP_011518037.1; XM_011519735.1. [Q9H098-1]
DR RefSeq; XP_016872235.1; XM_017016746.1.
DR RefSeq; XP_016872236.1; XM_017016747.1.
DR RefSeq; XP_016872237.1; XM_017016748.1.
DR RefSeq; XP_016872238.1; XM_017016749.1. [Q9H098-1]
DR AlphaFoldDB; Q9H098; -.
DR SMR; Q9H098; -.
DR BioGRID; 123705; 17.
DR IntAct; Q9H098; 2.
DR STRING; 9606.ENSP00000181796; -.
DR iPTMnet; Q9H098; -.
DR PhosphoSitePlus; Q9H098; -.
DR BioMuta; FAM107B; -.
DR DMDM; 74752552; -.
DR EPD; Q9H098; -.
DR jPOST; Q9H098; -.
DR MassIVE; Q9H098; -.
DR MaxQB; Q9H098; -.
DR PaxDb; Q9H098; -.
DR PeptideAtlas; Q9H098; -.
DR PRIDE; Q9H098; -.
DR ProteomicsDB; 80227; -. [Q9H098-1]
DR ProteomicsDB; 80228; -. [Q9H098-2]
DR TopDownProteomics; Q9H098-1; -. [Q9H098-1]
DR Antibodypedia; 50918; 60 antibodies from 11 providers.
DR DNASU; 83641; -.
DR Ensembl; ENST00000181796.7; ENSP00000181796.2; ENSG00000065809.14. [Q9H098-2]
DR Ensembl; ENST00000378458.6; ENSP00000367719.2; ENSG00000065809.14. [Q9H098-1]
DR Ensembl; ENST00000378462.5; ENSP00000367723.1; ENSG00000065809.14. [Q9H098-1]
DR Ensembl; ENST00000378465.7; ENSP00000367726.3; ENSG00000065809.14. [Q9H098-1]
DR Ensembl; ENST00000378467.8; ENSP00000367728.4; ENSG00000065809.14. [Q9H098-1]
DR Ensembl; ENST00000378470.5; ENSP00000367731.1; ENSG00000065809.14. [Q9H098-1]
DR Ensembl; ENST00000468747.5; ENSP00000418120.1; ENSG00000065809.14. [Q9H098-1]
DR Ensembl; ENST00000478076.5; ENSP00000417782.1; ENSG00000065809.14. [Q9H098-1]
DR Ensembl; ENST00000479731.5; ENSP00000419603.1; ENSG00000065809.14. [Q9H098-1]
DR Ensembl; ENST00000496330.5; ENSP00000418330.1; ENSG00000065809.14. [Q9H098-1]
DR Ensembl; ENST00000622567.4; ENSP00000479842.1; ENSG00000065809.14. [Q9H098-1]
DR GeneID; 83641; -.
DR KEGG; hsa:83641; -.
DR MANE-Select; ENST00000181796.7; ENSP00000181796.2; NM_031453.4; NP_113641.2. [Q9H098-2]
DR UCSC; uc001imx.3; human. [Q9H098-1]
DR CTD; 83641; -.
DR DisGeNET; 83641; -.
DR GeneCards; FAM107B; -.
DR HGNC; HGNC:23726; FAM107B.
DR HPA; ENSG00000065809; Low tissue specificity.
DR neXtProt; NX_Q9H098; -.
DR OpenTargets; ENSG00000065809; -.
DR PharmGKB; PA134902915; -.
DR VEuPathDB; HostDB:ENSG00000065809; -.
DR eggNOG; ENOG502RY4N; Eukaryota.
DR GeneTree; ENSGT00390000011228; -.
DR HOGENOM; CLU_078816_0_0_1; -.
DR InParanoid; Q9H098; -.
DR OMA; IMNQKRG; -.
DR OrthoDB; 1491333at2759; -.
DR PhylomeDB; Q9H098; -.
DR TreeFam; TF325943; -.
DR PathwayCommons; Q9H098; -.
DR SignaLink; Q9H098; -.
DR BioGRID-ORCS; 83641; 8 hits in 1080 CRISPR screens.
DR ChiTaRS; FAM107B; human.
DR GenomeRNAi; 83641; -.
DR Pharos; Q9H098; Tbio.
DR PRO; PR:Q9H098; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q9H098; protein.
DR Bgee; ENSG00000065809; Expressed in corpus callosum and 191 other tissues.
DR ExpressionAtlas; Q9H098; baseline and differential.
DR Genevisible; Q9H098; HS.
DR InterPro; IPR009533; FAM107.
DR PANTHER; PTHR16768; PTHR16768; 1.
DR Pfam; PF06625; DUF1151; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Coiled coil; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330"
FT CHAIN 2..131
FT /note="Protein FAM107B"
FT /id="PRO_0000230774"
FT REGION 39..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 61..112
FT /evidence="ECO:0000255"
FT COMPBIAS 53..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:19413330"
FT MOD_RES 50
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q3TGF2"
FT VAR_SEQ 1
FT /note="M -> MSTWKARLTKRLKSPSRSMHPFPCSALLACFGNTRESASFNQSGVAD
FT THSTVRVQPVAKAGRQPRHPSAEGAPEKRQDSSTHAERNGSANRNSSHRTAAQPAETPE
FT DVPGSLDDGADCEAVVFHASIPRPSIIDTPKEEEFREEPKCLELEQKMTSDSPPEDIDH
FT KDSYLITRSIM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037527"
SQ SEQUENCE 131 AA; 15558 MW; 6BEC6C5F02F679D4 CRC64;
MAEPDYIEDD NPELIRPQKL INPVKTSRNH QDLHRELLMN QKRGLAPQNK PELQKVMEKR
KRDQVIKQKE EEAQKKKSDL EIELLKRQQK LEQLELEKQK LQEEQENAPE FVKVKGNLRR
TGQEVAQAQE S
