F107B_MOUSE
ID F107B_MOUSE Reviewed; 131 AA.
AC Q3TGF2; Q9CR82;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Protein FAM107B {ECO:0000305};
GN Name=Fam107b {ECO:0000312|MGI:MGI:1913790};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, Heart, Testis, and Wolffian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-50, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [7]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND ABSENCE OF INDUCTION.
RX PubMed=25637808; DOI=10.1016/j.neuroscience.2015.01.026;
RA Masana M., Jukic M.M., Kretzschmar A., Wagner K.V., Westerholz S.,
RA Schmidt M.V., Rein T., Brodski C., Mueller M.B.;
RT "Deciphering the spatio-temporal expression and stress regulation of
RT Fam107B, the paralog of the resilience-promoting protein DRR1 in the mouse
RT brain.";
RL Neuroscience 290:147-158(2015).
CC -!- TISSUE SPECIFICITY: Expressed in the hippocampus and hypothalamus.
CC Expressed in the pontine nuclei and reticulotegmental nucleus.
CC Expressed in Purkinje cell and nuclear layers of the cerebelum.
CC Expressed in the choroid plexus. Expressed in hippocampal granule
CC neurons of the dente gyrus. {ECO:0000269|PubMed:25637808}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the developing brain embryo.
CC Expressed in the mesencephalon in the tectum at 12.5 dpc and in the
CC inferior colliculus at 16.5 dpc until birth. Expressed in the
CC telencephalon in the ventricular zone, cortical plate, ganglionic
CC eminence and hippocampus from 14.5 to 18.5 dpc. Expressed in the
CC rhombencephalon in the pontine nuclei and in the external granule layer
CC of the cerebellum at 16.5 and 18.5 dpc. {ECO:0000269|PubMed:25637808}.
CC -!- INDUCTION: Is not up-regulated in the hippocampus by acute social
CC defeat stress or glucocorticoids stimulation.
CC {ECO:0000269|PubMed:25637808}.
CC -!- SIMILARITY: Belongs to the FAM107 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE40596.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK032875; BAC28065.1; -; mRNA.
DR EMBL; AK013932; BAB29065.1; -; mRNA.
DR EMBL; AK019815; BAB31861.1; -; mRNA.
DR EMBL; AK168759; BAE40596.1; ALT_INIT; mRNA.
DR EMBL; AL844530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466542; EDL07938.1; -; Genomic_DNA.
DR EMBL; BC021353; AAH21353.1; -; mRNA.
DR CCDS; CCDS15655.1; -.
DR RefSeq; NP_079902.1; NM_025626.4.
DR AlphaFoldDB; Q3TGF2; -.
DR SMR; Q3TGF2; -.
DR BioGRID; 211545; 5.
DR IntAct; Q3TGF2; 6.
DR STRING; 10090.ENSMUSP00000027965; -.
DR iPTMnet; Q3TGF2; -.
DR PhosphoSitePlus; Q3TGF2; -.
DR EPD; Q3TGF2; -.
DR MaxQB; Q3TGF2; -.
DR PaxDb; Q3TGF2; -.
DR PRIDE; Q3TGF2; -.
DR ProteomicsDB; 275710; -.
DR Antibodypedia; 50918; 60 antibodies from 11 providers.
DR DNASU; 66540; -.
DR Ensembl; ENSMUST00000027965; ENSMUSP00000027965; ENSMUSG00000026655.
DR Ensembl; ENSMUST00000115053; ENSMUSP00000110705; ENSMUSG00000026655.
DR Ensembl; ENSMUST00000115054; ENSMUSP00000110706; ENSMUSG00000026655.
DR Ensembl; ENSMUST00000115055; ENSMUSP00000110707; ENSMUSG00000026655.
DR GeneID; 66540; -.
DR KEGG; mmu:66540; -.
DR UCSC; uc008iek.1; mouse.
DR CTD; 83641; -.
DR MGI; MGI:1913790; Fam107b.
DR VEuPathDB; HostDB:ENSMUSG00000026655; -.
DR eggNOG; ENOG502RY4N; Eukaryota.
DR GeneTree; ENSGT00390000011228; -.
DR HOGENOM; CLU_122902_0_0_1; -.
DR InParanoid; Q3TGF2; -.
DR OrthoDB; 1491333at2759; -.
DR PhylomeDB; Q3TGF2; -.
DR TreeFam; TF325943; -.
DR BioGRID-ORCS; 66540; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Fam107b; mouse.
DR PRO; PR:Q3TGF2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q3TGF2; protein.
DR Bgee; ENSMUSG00000026655; Expressed in granulocyte and 254 other tissues.
DR ExpressionAtlas; Q3TGF2; baseline and differential.
DR Genevisible; Q3TGF2; MM.
DR GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
DR InterPro; IPR009533; FAM107.
DR PANTHER; PTHR16768; PTHR16768; 1.
DR Pfam; PF06625; DUF1151; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9H098"
FT CHAIN 2..131
FT /note="Protein FAM107B"
FT /id="PRO_0000230775"
FT REGION 39..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 61..112
FT /evidence="ECO:0000255"
FT COMPBIAS 53..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9H098"
FT MOD_RES 50
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
SQ SEQUENCE 131 AA; 15572 MW; 13A5FE0FB42D0343 CRC64;
MAEPDYIEDD NPELIRPQKL INPVKSSRNH QDLHRELLMN QKRGLAPQNK PELQKVMEKR
RRDQVIKQKE EEAQKKKSDL EIELLKRQQK LEQLELEKQK LQEEQENAPE FVKVKGNLRR
TGQEVAQAQE S
