F10C1_MOUSE
ID F10C1_MOUSE Reviewed; 315 AA.
AC Q8BP78; F8VPM5; Q1LZ54; Q3T9W6;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 3.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Protein FRA10AC1 homolog;
GN Name=Fra10ac1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryo, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION.
RX PubMed=15203205; DOI=10.1016/j.ygeno.2003.12.017;
RA Sarafidou T., Kahl C., Martinez-Garay I., Mangelsdorf M., Gesk S.,
RA Baker E., Kokkinaki M., Talley P., Maltby E.L., French L., Harder L.,
RA Hinzmann B., Nobile C., Richkind K., Finnis M., Deloukas P.,
RA Sutherland G.R., Kutsche K., Moschonas N.K., Siebert R., Gecz J.;
RT "Folate-sensitive fragile site FRA10A is due to an expansion of a CGG
RT repeat in a novel gene, FRA10AC1, encoding a nuclear protein.";
RL Genomics 84:69-81(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE
RP ANALYSIS] AT SER-12; SER-283 AND SER-285, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283 AND SER-285, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-36, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK017666; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BAC36871.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK017666; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK077572; BAC36871.1; ALT_INIT; mRNA.
DR EMBL; AK172241; BAE42904.1; -; mRNA.
DR EMBL; AC112153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BN000292; CAE47417.1; -; mRNA.
DR CCDS; CCDS37972.1; -.
DR RefSeq; NP_001074544.1; NM_001081075.1.
DR RefSeq; XP_006527397.1; XM_006527334.1.
DR RefSeq; XP_006527398.1; XM_006527335.3.
DR AlphaFoldDB; Q8BP78; -.
DR BioGRID; 214139; 2.
DR STRING; 10090.ENSMUSP00000070534; -.
DR iPTMnet; Q8BP78; -.
DR PhosphoSitePlus; Q8BP78; -.
DR EPD; Q8BP78; -.
DR jPOST; Q8BP78; -.
DR MaxQB; Q8BP78; -.
DR PaxDb; Q8BP78; -.
DR PeptideAtlas; Q8BP78; -.
DR PRIDE; Q8BP78; -.
DR ProteomicsDB; 275956; -.
DR Antibodypedia; 30489; 101 antibodies from 18 providers.
DR DNASU; 70567; -.
DR Ensembl; ENSMUST00000067167; ENSMUSP00000070534; ENSMUSG00000054237.
DR GeneID; 70567; -.
DR KEGG; mmu:70567; -.
DR UCSC; uc008hjg.1; mouse.
DR CTD; 118924; -.
DR MGI; MGI:1917817; Fra10ac1.
DR VEuPathDB; HostDB:ENSMUSG00000054237; -.
DR eggNOG; KOG1297; Eukaryota.
DR GeneTree; ENSGT00390000017833; -.
DR HOGENOM; CLU_061714_0_1_1; -.
DR InParanoid; Q8BP78; -.
DR OMA; HKLNFHH; -.
DR OrthoDB; 1444601at2759; -.
DR PhylomeDB; Q8BP78; -.
DR TreeFam; TF323667; -.
DR BioGRID-ORCS; 70567; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Fra10ac1; mouse.
DR PRO; PR:Q8BP78; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8BP78; protein.
DR Bgee; ENSMUSG00000054237; Expressed in otolith organ and 229 other tissues.
DR Genevisible; Q8BP78; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IBA:GO_Central.
DR InterPro; IPR019129; Folate-sensitive_fs_Fra10Ac1.
DR Pfam; PF09725; Fra10Ac1; 1.
PE 1: Evidence at protein level;
KW Acetylation; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..315
FT /note="Protein FRA10AC1 homolog"
FT /id="PRO_0000087149"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:17242355"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5FVF1"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355"
FT MOD_RES 36
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 283
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 285
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT CONFLICT 1
FT /note="M -> K (in Ref. 1; BAC36871)"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="L -> I (in Ref. 1; BAE42904)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="S -> F (in Ref. 1; BAC36871)"
FT /evidence="ECO:0000305"
FT CONFLICT 298
FT /note="D -> N (in Ref. 1; BAC36871)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 37202 MW; B3DF1FE7F25878EB CRC64;
MHGHGGYDSD FSDDEQGGGS SKKRKKTVED ELLLTKPFQK ERHGKVAHKQ VAADLLDREE
ARNRRFHLIA MDAYQRHTKF VNDYILYYGG KREDFKRLGE NDKTDLDVIR ENHRFLWNEE
DEADMTWEKR LAKKYYDKLF KEYCIADLSR YKENKFGFRW RIEKEVISGK GQFFCGNKCC
NEKEGLRSWE VNFGYTEHGE KRNALVKLRL CQECSFKLNF HHRRKEIKST KKKSKTTPEC
DESPRKKSRS PPSEEASKGK DEGHSSSKKS EDSRNRNAEE EDSASDSELW KGPLPETDEK
SQEEEFDDYF QDLFL
