F110A_HUMAN
ID F110A_HUMAN Reviewed; 295 AA.
AC Q9BQ89; D3DVW2; Q5R1M7;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Protein FAM110A;
GN Name=FAM110A; Synonyms=C20orf55, F10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH CSPP1,
RP DEVELOPMENTAL STAGE, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=17499476; DOI=10.1016/j.ygeno.2007.03.002;
RA Hauge H., Patzke S., Aasheim H.-C.;
RT "Characterization of the FAM110 gene family.";
RL Genomics 90:14-27(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Choriocarcinoma;
RA Zhou J., Chen S., Xin F., Pang Z., Li B., Zhou W., Fu X., Ding Y.;
RT "Study of a new gene F10 in hydatidiform mole and association with
RT trophoblastic tumor invasiveness.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: May interact with CSPP1. {ECO:0000305}.
CC -!- INTERACTION:
CC Q9BQ89; O95994: AGR2; NbExp=5; IntAct=EBI-1752811, EBI-712648;
CC Q9BQ89; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-1752811, EBI-11975051;
CC Q9BQ89; O95273: CCNDBP1; NbExp=3; IntAct=EBI-1752811, EBI-748961;
CC Q9BQ89; Q01850: CDR2; NbExp=3; IntAct=EBI-1752811, EBI-1181367;
CC Q9BQ89; Q9H9E3: COG4; NbExp=3; IntAct=EBI-1752811, EBI-368382;
CC Q9BQ89; Q9Y2V7: COG6; NbExp=3; IntAct=EBI-1752811, EBI-3866319;
CC Q9BQ89; P49674: CSNK1E; NbExp=3; IntAct=EBI-1752811, EBI-749343;
CC Q9BQ89; Q9GZU7: CTDSP1; NbExp=3; IntAct=EBI-1752811, EBI-751587;
CC Q9BQ89; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-1752811, EBI-11962928;
CC Q9BQ89; Q12805: EFEMP1; NbExp=3; IntAct=EBI-1752811, EBI-536772;
CC Q9BQ89; O95967: EFEMP2; NbExp=3; IntAct=EBI-1752811, EBI-743414;
CC Q9BQ89; Q13643: FHL3; NbExp=3; IntAct=EBI-1752811, EBI-741101;
CC Q9BQ89; A1L4K1: FSD2; NbExp=3; IntAct=EBI-1752811, EBI-5661036;
CC Q9BQ89; Q08379: GOLGA2; NbExp=6; IntAct=EBI-1752811, EBI-618309;
CC Q9BQ89; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-1752811, EBI-5916454;
CC Q9BQ89; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-1752811, EBI-10961706;
CC Q9BQ89; O75031: HSF2BP; NbExp=3; IntAct=EBI-1752811, EBI-7116203;
CC Q9BQ89; P19012: KRT15; NbExp=6; IntAct=EBI-1752811, EBI-739566;
CC Q9BQ89; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-1752811, EBI-3044087;
CC Q9BQ89; Q15323: KRT31; NbExp=6; IntAct=EBI-1752811, EBI-948001;
CC Q9BQ89; O76011: KRT34; NbExp=3; IntAct=EBI-1752811, EBI-1047093;
CC Q9BQ89; O76014: KRT37; NbExp=3; IntAct=EBI-1752811, EBI-1045716;
CC Q9BQ89; O76015: KRT38; NbExp=3; IntAct=EBI-1752811, EBI-1047263;
CC Q9BQ89; Q6A163: KRT39; NbExp=3; IntAct=EBI-1752811, EBI-11958242;
CC Q9BQ89; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-1752811, EBI-10171774;
CC Q9BQ89; O95751: LDOC1; NbExp=3; IntAct=EBI-1752811, EBI-740738;
CC Q9BQ89; Q8N485: LIX1; NbExp=3; IntAct=EBI-1752811, EBI-10694501;
CC Q9BQ89; Q99687-3: MEIS3; NbExp=3; IntAct=EBI-1752811, EBI-18582591;
CC Q9BQ89; A9UHW6-2: MIF4GD; NbExp=3; IntAct=EBI-1752811, EBI-9118295;
CC Q9BQ89; Q13064: MKRN3; NbExp=6; IntAct=EBI-1752811, EBI-2340269;
CC Q9BQ89; Q5JR59-3: MTUS2; NbExp=4; IntAct=EBI-1752811, EBI-11522433;
CC Q9BQ89; P15173: MYOG; NbExp=3; IntAct=EBI-1752811, EBI-3906629;
CC Q9BQ89; P16333: NCK1; NbExp=2; IntAct=EBI-1752811, EBI-389883;
CC Q9BQ89; Q99471: PFDN5; NbExp=3; IntAct=EBI-1752811, EBI-357275;
CC Q9BQ89; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-1752811, EBI-302345;
CC Q9BQ89; A6NK89: RASSF10; NbExp=5; IntAct=EBI-1752811, EBI-6912267;
CC Q9BQ89; Q86WH2: RASSF3; NbExp=3; IntAct=EBI-1752811, EBI-2845202;
CC Q9BQ89; Q15293: RCN1; NbExp=3; IntAct=EBI-1752811, EBI-948278;
CC Q9BQ89; Q6NUQ1: RINT1; NbExp=6; IntAct=EBI-1752811, EBI-726876;
CC Q9BQ89; Q9HAT0: ROPN1; NbExp=3; IntAct=EBI-1752811, EBI-1378139;
CC Q9BQ89; O75558: STX11; NbExp=3; IntAct=EBI-1752811, EBI-714135;
CC Q9BQ89; P15884-3: TCF4; NbExp=3; IntAct=EBI-1752811, EBI-13636688;
CC Q9BQ89; P36406: TRIM23; NbExp=6; IntAct=EBI-1752811, EBI-740098;
CC Q9BQ89; P14373: TRIM27; NbExp=3; IntAct=EBI-1752811, EBI-719493;
CC Q9BQ89; Q9BYV2: TRIM54; NbExp=6; IntAct=EBI-1752811, EBI-2130429;
CC Q9BQ89; Q86WT6: TRIM69; NbExp=3; IntAct=EBI-1752811, EBI-749955;
CC Q9BQ89; Q86WT6-2: TRIM69; NbExp=6; IntAct=EBI-1752811, EBI-11525489;
CC Q9BQ89; Q86WV8: TSC1; NbExp=3; IntAct=EBI-1752811, EBI-12806590;
CC Q9BQ89; Q99816: TSG101; NbExp=3; IntAct=EBI-1752811, EBI-346882;
CC Q9BQ89; Q8N6Y0: USHBP1; NbExp=6; IntAct=EBI-1752811, EBI-739895;
CC Q9BQ89; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-1752811, EBI-2799833;
CC Q9BQ89; Q8NAM6: ZSCAN4; NbExp=3; IntAct=EBI-1752811, EBI-7252920;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17499476}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000269|PubMed:17499476}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000269|PubMed:17499476}. Note=Distributed throughout the
CC cytoplasm during mitosis, accumulating at spindle poles.
CC -!- TISSUE SPECIFICITY: Detected in thyroid, lymph node, trachea, adrenal
CC gland, bone marrow, spleen, thymus, prostate, and peripheral blood
CC leukocyte. Detected at lower levels in stomach, testis and spinal cord.
CC {ECO:0000269|PubMed:17499476}.
CC -!- DEVELOPMENTAL STAGE: During the cell cycle, expression is increased
CC during S phase and G2/M phase. {ECO:0000269|PubMed:17499476}.
CC -!- INDUCTION: Up-regulated in stimulated lymphocytes.
CC {ECO:0000269|PubMed:17499476}.
CC -!- SIMILARITY: Belongs to the FAM110 family. {ECO:0000305}.
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DR EMBL; DQ431181; ABD92773.1; -; mRNA.
DR EMBL; AB196290; BAD77807.1; -; mRNA.
DR EMBL; AL118502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10655.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10656.1; -; Genomic_DNA.
DR EMBL; BC004222; AAH04222.1; -; mRNA.
DR EMBL; BC012800; AAH12800.1; -; mRNA.
DR EMBL; BC022238; AAH22238.1; -; mRNA.
DR CCDS; CCDS13008.1; -.
DR RefSeq; NP_001035812.1; NM_001042353.2.
DR RefSeq; NP_001276074.1; NM_001289145.1.
DR RefSeq; NP_001276075.1; NM_001289146.1.
DR RefSeq; NP_001276076.1; NM_001289147.1.
DR RefSeq; NP_113612.1; NM_031424.5.
DR RefSeq; NP_997004.1; NM_207121.4.
DR RefSeq; XP_011527683.1; XM_011529381.2.
DR AlphaFoldDB; Q9BQ89; -.
DR BioGRID; 123674; 100.
DR IntAct; Q9BQ89; 60.
DR MINT; Q9BQ89; -.
DR STRING; 9606.ENSP00000354163; -.
DR iPTMnet; Q9BQ89; -.
DR PhosphoSitePlus; Q9BQ89; -.
DR BioMuta; FAM110A; -.
DR DMDM; 26392452; -.
DR EPD; Q9BQ89; -.
DR jPOST; Q9BQ89; -.
DR MassIVE; Q9BQ89; -.
DR MaxQB; Q9BQ89; -.
DR PaxDb; Q9BQ89; -.
DR PeptideAtlas; Q9BQ89; -.
DR PRIDE; Q9BQ89; -.
DR ProteomicsDB; 78643; -.
DR TopDownProteomics; Q9BQ89; -.
DR Antibodypedia; 66693; 56 antibodies from 13 providers.
DR DNASU; 83541; -.
DR Ensembl; ENST00000246100.3; ENSP00000246100.3; ENSG00000125898.13.
DR Ensembl; ENST00000304189.6; ENSP00000354163.2; ENSG00000125898.13.
DR Ensembl; ENST00000381939.1; ENSP00000371365.1; ENSG00000125898.13.
DR Ensembl; ENST00000381941.8; ENSP00000371367.3; ENSG00000125898.13.
DR Ensembl; ENST00000541082.2; ENSP00000445228.1; ENSG00000125898.13.
DR GeneID; 83541; -.
DR KEGG; hsa:83541; -.
DR MANE-Select; ENST00000381941.8; ENSP00000371367.3; NM_001042353.3; NP_001035812.1.
DR UCSC; uc002wef.3; human.
DR CTD; 83541; -.
DR DisGeNET; 83541; -.
DR GeneCards; FAM110A; -.
DR HGNC; HGNC:16188; FAM110A.
DR HPA; ENSG00000125898; Tissue enhanced (esophagus, skin).
DR MIM; 611393; gene.
DR neXtProt; NX_Q9BQ89; -.
DR OpenTargets; ENSG00000125898; -.
DR PharmGKB; PA162385650; -.
DR VEuPathDB; HostDB:ENSG00000125898; -.
DR eggNOG; ENOG502R37V; Eukaryota.
DR GeneTree; ENSGT00950000183056; -.
DR HOGENOM; CLU_050540_0_0_1; -.
DR InParanoid; Q9BQ89; -.
DR OMA; GGCSHRS; -.
DR OrthoDB; 745936at2759; -.
DR PhylomeDB; Q9BQ89; -.
DR TreeFam; TF330964; -.
DR PathwayCommons; Q9BQ89; -.
DR SignaLink; Q9BQ89; -.
DR BioGRID-ORCS; 83541; 19 hits in 1085 CRISPR screens.
DR ChiTaRS; FAM110A; human.
DR GenomeRNAi; 83541; -.
DR Pharos; Q9BQ89; Tdark.
DR PRO; PR:Q9BQ89; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9BQ89; protein.
DR Bgee; ENSG00000125898; Expressed in upper arm skin and 117 other tissues.
DR ExpressionAtlas; Q9BQ89; baseline and differential.
DR Genevisible; Q9BQ89; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR InterPro; IPR025740; FAM110.
DR InterPro; IPR025741; FAM110_C.
DR InterPro; IPR025739; FAM110_N.
DR PANTHER; PTHR14758; PTHR14758; 1.
DR Pfam; PF14160; FAM110_C; 1.
DR Pfam; PF14161; FAM110_N; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..295
FT /note="Protein FAM110A"
FT /id="PRO_0000079435"
FT REGION 117..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..148
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..177
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 284
FT /note="L -> I (in dbSNP:rs6055290)"
FT /id="VAR_060150"
SQ SEQUENCE 295 AA; 31271 MW; 49E4B4B874E1CF46 CRC64;
MPVHTLSPGA PSAPALPCRL RTRVPGYLLR GPADGGARKP SAVERLEADK AKYVKSLHVA
NTRQEPVQPL LSKQPLFSPE TRRTVLTPSR RALPGPCRRP QLDLDILSSL IDLCDSPVSP
AEASRTPGRA EGAGRPPPAT PPRPPPSTSA VRRVDVRPLP ASPARPCPSP GPAAASSPAR
PPGLQRSKSD LSERFSRAAA DLERFFNFCG LDPEEARGLG VAHLARASSD IVSLAGPSAG
PGSSEGGCSR RSSVTVEERA RERVPYGVSV VERNARVIKW LYGLRQARES PAAEG
