F110A_MOUSE
ID F110A_MOUSE Reviewed; 296 AA.
AC Q8R184; Q505P3; Q8BQE5; Q8K024; Q8VEM7; Q9CU80;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Protein FAM110A;
GN Name=Fam110a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: May interact with CSPP1. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
CC Note=Distributed throughout the cytoplasm during mitosis, accumulating
CC at spindle poles. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FAM110 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BC018162; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK050928; BAC34464.1; -; mRNA.
DR EMBL; AL845161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC018162; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC025092; AAH25092.1; -; mRNA.
DR EMBL; BC034240; AAH34240.1; -; mRNA.
DR EMBL; BC094463; AAH94463.1; -; mRNA.
DR CCDS; CCDS16875.1; -.
DR RefSeq; NP_001276079.1; NM_001289150.1.
DR RefSeq; NP_001276080.1; NM_001289151.1.
DR RefSeq; NP_082942.2; NM_028666.3.
DR RefSeq; NP_666239.1; NM_146127.3.
DR RefSeq; XP_006500329.1; XM_006500266.3.
DR AlphaFoldDB; Q8R184; -.
DR STRING; 10090.ENSMUSP00000105491; -.
DR iPTMnet; Q8R184; -.
DR PhosphoSitePlus; Q8R184; -.
DR EPD; Q8R184; -.
DR MaxQB; Q8R184; -.
DR PaxDb; Q8R184; -.
DR PRIDE; Q8R184; -.
DR ProteomicsDB; 275492; -.
DR Antibodypedia; 66693; 56 antibodies from 13 providers.
DR Ensembl; ENSMUST00000062047; ENSMUSP00000053266; ENSMUSG00000027459.
DR Ensembl; ENSMUST00000109863; ENSMUSP00000105489; ENSMUSG00000027459.
DR Ensembl; ENSMUST00000109864; ENSMUSP00000105490; ENSMUSG00000027459.
DR Ensembl; ENSMUST00000109865; ENSMUSP00000105491; ENSMUSG00000027459.
DR GeneID; 73847; -.
DR KEGG; mmu:73847; -.
DR UCSC; uc008ner.2; mouse.
DR CTD; 83541; -.
DR MGI; MGI:1921097; Fam110a.
DR VEuPathDB; HostDB:ENSMUSG00000027459; -.
DR eggNOG; ENOG502R37V; Eukaryota.
DR GeneTree; ENSGT00950000183056; -.
DR HOGENOM; CLU_050540_0_0_1; -.
DR InParanoid; Q8R184; -.
DR OMA; GGCSHRS; -.
DR OrthoDB; 745936at2759; -.
DR PhylomeDB; Q8R184; -.
DR TreeFam; TF330964; -.
DR BioGRID-ORCS; 73847; 4 hits in 75 CRISPR screens.
DR ChiTaRS; Fam110a; mouse.
DR PRO; PR:Q8R184; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8R184; protein.
DR Bgee; ENSMUSG00000027459; Expressed in seminiferous tubule of testis and 131 other tissues.
DR Genevisible; Q8R184; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR InterPro; IPR025740; FAM110.
DR InterPro; IPR025741; FAM110_C.
DR InterPro; IPR025739; FAM110_N.
DR PANTHER; PTHR14758; PTHR14758; 1.
DR Pfam; PF14160; FAM110_C; 1.
DR Pfam; PF14161; FAM110_N; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..296
FT /note="Protein FAM110A"
FT /id="PRO_0000079436"
FT REGION 61..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 261
FT /note="S -> A (in Ref. 3; AAH25092)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 296 AA; 31582 MW; 5F0A9660D3572CF9 CRC64;
MPVDTLSPGA PATPALPFRL RTKVPGYLLP RPADGGARKP SAVERLEADK AKYVKSLRVA
NTRQEPVQPP LVRQPLFSPG PRGPVLTPSR RVLPCSGRRP QLDLDILSSL INLCDSPVSP
SEASRTPGRP EGSAHKVPPA TPPRPPPSTV AVRRVDVRPL PASPARPYPS PGTTTTSSPG
RPPGLQRSKS DLSERFSRAA ADLERFFNFC GLDPEEARGL GVAHLARASS DIVSLAGPSA
GPCSSEGGCS RRSSATVEER SLDRVPYGVS VIERNARVIK WLYGLRQARD PPTTEG
