F110B_MOUSE
ID F110B_MOUSE Reviewed; 366 AA.
AC Q8C739; Q3UKH0;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein FAM110B;
GN Name=Fam110b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney, Placenta, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234 AND SER-297, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the FAM110 family. {ECO:0000305}.
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DR EMBL; AK052596; BAC35053.1; -; mRNA.
DR EMBL; AK146011; BAE26831.1; -; mRNA.
DR EMBL; AK159054; BAE34787.1; -; mRNA.
DR EMBL; AL732614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC055683; AAH55683.1; -; mRNA.
DR CCDS; CCDS17948.1; -.
DR RefSeq; NP_775602.1; NM_173426.2.
DR RefSeq; XP_006537958.1; XM_006537895.3.
DR RefSeq; XP_006537959.1; XM_006537896.3.
DR RefSeq; XP_006537960.1; XM_006537897.1.
DR RefSeq; XP_006537961.1; XM_006537898.3.
DR AlphaFoldDB; Q8C739; -.
DR SMR; Q8C739; -.
DR BioGRID; 232392; 4.
DR STRING; 10090.ENSMUSP00000062734; -.
DR iPTMnet; Q8C739; -.
DR PhosphoSitePlus; Q8C739; -.
DR jPOST; Q8C739; -.
DR MaxQB; Q8C739; -.
DR PaxDb; Q8C739; -.
DR PeptideAtlas; Q8C739; -.
DR PRIDE; Q8C739; -.
DR ProteomicsDB; 275493; -.
DR Antibodypedia; 2031; 94 antibodies from 13 providers.
DR DNASU; 242297; -.
DR Ensembl; ENSMUST00000054857; ENSMUSP00000062734; ENSMUSG00000049119.
DR Ensembl; ENSMUST00000108380; ENSMUSP00000104017; ENSMUSG00000049119.
DR Ensembl; ENSMUST00000171403; ENSMUSP00000127942; ENSMUSG00000049119.
DR GeneID; 242297; -.
DR KEGG; mmu:242297; -.
DR UCSC; uc008rxe.1; mouse.
DR CTD; 90362; -.
DR MGI; MGI:1916593; Fam110b.
DR VEuPathDB; HostDB:ENSMUSG00000049119; -.
DR eggNOG; ENOG502R37V; Eukaryota.
DR GeneTree; ENSGT00950000183056; -.
DR HOGENOM; CLU_050540_0_0_1; -.
DR InParanoid; Q8C739; -.
DR OMA; VCPGAKR; -.
DR OrthoDB; 745936at2759; -.
DR PhylomeDB; Q8C739; -.
DR TreeFam; TF330964; -.
DR BioGRID-ORCS; 242297; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Fam110b; mouse.
DR PRO; PR:Q8C739; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8C739; protein.
DR Bgee; ENSMUSG00000049119; Expressed in caudate-putamen and 208 other tissues.
DR ExpressionAtlas; Q8C739; baseline and differential.
DR Genevisible; Q8C739; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR InterPro; IPR025740; FAM110.
DR InterPro; IPR025741; FAM110_C.
DR InterPro; IPR025739; FAM110_N.
DR PANTHER; PTHR14758; PTHR14758; 1.
DR Pfam; PF14160; FAM110_C; 1.
DR Pfam; PF14161; FAM110_N; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT CHAIN 1..366
FT /note="Protein FAM110B"
FT /id="PRO_0000285652"
FT REGION 127..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 234
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 297
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 271
FT /note="E -> D (in Ref. 1; BAE26831)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 366 AA; 40360 MW; B5DE416119777BBA CRC64;
MPTETLQTGS MVKPVSPAGT FTSAVPLRIL NKGPDYFRRQ AEPNPKRLSA VERLEADKAK
YVKSQEVINA KQEPVKPAVL AKPPVCPGTK RALGSPTLKV FGNHAKTESG VQRETLKLEI
LKNIINSSEG SSSGSGHKHS SRNWPPHRDT TDLHRHSFAE SLKVYPTPGH GSPQESSSHV
SRRLLEQSAE TFLHVSHSSS DIRKVTSVKP LKAIPCSSSA PPLPPKPKVA AMKSPEADQV
EPACGVSRRP SLQRSKSDLS DRYFRVDADV ERFFNYCGLD PEELENLGME NFARANSDII
SLNFRSASMI SSDCEQSQDS NSDLRNDDSA NDRVPYGISA IERNARIIKW LYSIKQARES
QKVSHV
