ID   F110C_RAT               Reviewed;         326 AA.
AC   Q5RKJ0;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Protein FAM110C;
GN   Name=Fam110c;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in microtubule organization. May play a role
CC       in cell spreading and cell migration of epithelial cells; the function
CC       may involve the AKT1 signaling pathway. {ECO:0000250|UniProtKB:Q1W6H9}.
CC   -!- SUBUNIT: Interacts with AKT1; the interaction is transient and follows
CC       AKT1 activation. Interacts with PPP2CA and alpha-tubulin.
CC       {ECO:0000250|UniProtKB:Q1W6H9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q1W6H9}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:Q1W6H9}.
CC       Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q1W6H9}.
CC       Nucleus {ECO:0000250|UniProtKB:Q1W6H9}. Note=Colocalizes with
CC       microtubules during interphase. Detected at the mitotic spindle poles.
CC       Colocalizes with AKT1 at the cell cortex.
CC       {ECO:0000250|UniProtKB:Q1W6H9}.
CC   -!- SIMILARITY: Belongs to the FAM110 family. {ECO:0000305}.
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DR   EMBL; BC085778; AAH85778.1; -; mRNA.
DR   RefSeq; NP_001020222.1; NM_001025051.1.
DR   AlphaFoldDB; Q5RKJ0; -.
DR   STRING; 10116.ENSRNOP00000007466; -.
DR   PaxDb; Q5RKJ0; -.
DR   GeneID; 500638; -.
DR   KEGG; rno:500638; -.
DR   UCSC; RGD:1564713; rat.
DR   CTD; 642273; -.
DR   RGD; 1564713; Fam110c.
DR   VEuPathDB; HostDB:ENSRNOG00000005660; -.
DR   eggNOG; ENOG502S0DB; Eukaryota.
DR   HOGENOM; CLU_050540_0_0_1; -.
DR   InParanoid; Q5RKJ0; -.
DR   OMA; IAINIRS; -.
DR   OrthoDB; 745936at2759; -.
DR   PhylomeDB; Q5RKJ0; -.
DR   TreeFam; TF330964; -.
DR   PRO; PR:Q5RKJ0; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000005660; Expressed in duodenum and 12 other tissues.
DR   Genevisible; Q5RKJ0; RN.
DR   GO; GO:0005938; C:cell cortex; ISS:UniProtKB.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0043014; F:alpha-tubulin binding; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISS:UniProtKB.
DR   GO; GO:0060491; P:regulation of cell projection assembly; ISS:UniProtKB.
DR   InterPro; IPR025740; FAM110.
DR   InterPro; IPR025741; FAM110_C.
DR   PANTHER; PTHR14758; PTHR14758; 1.
DR   Pfam; PF14160; FAM110_C; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..326
FT                   /note="Protein FAM110C"
FT                   /id="PRO_0000293463"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          51..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         255
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q1W6H9"
SQ   SEQUENCE   326 AA;  35578 MW;  7AA2DCFA27928C62 CRC64;
     MRALPTLDSL ARTRPSLGDS RAAEGTLTRQ PANKSAVERL AADRAKYVRS TLGSSRGPVS
     ENRVPEAPGV QHRNPIPSTL APAPVARRAV ARKPLRPDSL VIYRQKCEFV RGSDADSSRV
     GLMKKFFQGS GKDKMSVTPE TTRVADEYKT KETEATWTKA SQAAAAKPAS MLPPPAPVVA
     MESPALPFEV APRVPVRRSG VELRASRSKG LQRSQSDLSS RYSTARAESD TFFQYCGLDP
     EVVESLGREN FSAASDCVTP KMRSVSMATS DSSFSRHSED GLQEEELLEQ VPSTTSVVER
     NARIIKWLFT CKKAKETPSQ KLQEPA