F110D_HUMAN
ID F110D_HUMAN Reviewed; 271 AA.
AC Q8TAY7; A8K3V0; Q9H7Z4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein FAM110D;
GN Name=FAM110D; Synonyms=GRRP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-53.
RC TISSUE=Embryo, and Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the FAM110 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14829.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK024112; BAB14829.1; ALT_FRAME; mRNA.
DR EMBL; AK290715; BAF83404.1; -; mRNA.
DR EMBL; AL391650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025658; AAH25658.1; -; mRNA.
DR CCDS; CCDS41285.1; -.
DR RefSeq; NP_079145.2; NM_024869.2.
DR AlphaFoldDB; Q8TAY7; -.
DR BioGRID; 123003; 27.
DR STRING; 9606.ENSP00000363386; -.
DR iPTMnet; Q8TAY7; -.
DR PhosphoSitePlus; Q8TAY7; -.
DR BioMuta; FAM110D; -.
DR DMDM; 74751367; -.
DR PaxDb; Q8TAY7; -.
DR PeptideAtlas; Q8TAY7; -.
DR PRIDE; Q8TAY7; -.
DR Antibodypedia; 2884; 76 antibodies from 15 providers.
DR DNASU; 79927; -.
DR Ensembl; ENST00000374268.5; ENSP00000363386.3; ENSG00000197245.6.
DR GeneID; 79927; -.
DR KEGG; hsa:79927; -.
DR MANE-Select; ENST00000374268.5; ENSP00000363386.3; NM_024869.3; NP_079145.2.
DR UCSC; uc001blk.3; human.
DR CTD; 79927; -.
DR GeneCards; FAM110D; -.
DR HGNC; HGNC:25860; FAM110D.
DR HPA; ENSG00000197245; Low tissue specificity.
DR neXtProt; NX_Q8TAY7; -.
DR OpenTargets; ENSG00000197245; -.
DR PharmGKB; PA142671706; -.
DR VEuPathDB; HostDB:ENSG00000197245; -.
DR eggNOG; ENOG502S0DB; Eukaryota.
DR GeneTree; ENSGT00950000183056; -.
DR HOGENOM; CLU_050540_1_0_1; -.
DR InParanoid; Q8TAY7; -.
DR OMA; KWLYGCQ; -.
DR OrthoDB; 745936at2759; -.
DR PhylomeDB; Q8TAY7; -.
DR TreeFam; TF330964; -.
DR PathwayCommons; Q8TAY7; -.
DR BioGRID-ORCS; 79927; 9 hits in 1069 CRISPR screens.
DR GenomeRNAi; 79927; -.
DR Pharos; Q8TAY7; Tdark.
DR PRO; PR:Q8TAY7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8TAY7; protein.
DR Bgee; ENSG00000197245; Expressed in left uterine tube and 101 other tissues.
DR Genevisible; Q8TAY7; HS.
DR InterPro; IPR025740; FAM110.
DR InterPro; IPR025741; FAM110_C.
DR InterPro; IPR025739; FAM110_N.
DR PANTHER; PTHR14758; PTHR14758; 1.
DR Pfam; PF14160; FAM110_C; 1.
DR Pfam; PF14161; FAM110_N; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..271
FT /note="Protein FAM110D"
FT /id="PRO_0000318716"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..67
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 53
FT /note="H -> R (in dbSNP:rs3748856)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_038860"
SQ SEQUENCE 271 AA; 28710 MW; 16F89810CDBEFCD5 CRC64;
MLLAPPSTPS RGRTPSAVER LEADKAKYVK THQVIARRQE PALRGSPGPL TPHPCNELGP
PASPRTPRPV RRGSGRRLPR PDSLIFYRQK RDCKASVNKE NAKGQGLVRR LFLGAPRDAA
PSSPASTERP AASGGWAAPQ DAPEAAGKRA LCPTCSLPLS EKERFFNYCG LERALVEVLG
AERFSPQSWG ADASPQAGTS PPPGSGDASD WTSSDRGVDS PGGAGGGGGS EAAGSARDRR
PPVSVVERNA RVIQWLYGCQ RARGPPRESE V
