F1142_HUMAN
ID F1142_HUMAN Reviewed; 505 AA.
AC Q9NRY5; B2R8D8; Q9H7E0;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 4.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein FAM114A2;
GN Name=FAM114A2; Synonyms=C5orf3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=10843801; DOI=10.1006/geno.2000.6193;
RA Boultwood J., Fidler C., Strickson A.J., Watkins F., Kostrzewa M.,
RA Jaju R.J., Muller U., Wainscoat J.S.;
RT "Transcription mapping of the 5q- syndrome critical region: cloning of two
RT novel genes and sequencing, expression, and mapping of a further six novel
RT cDNAs.";
RL Genomics 66:26-34(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-209, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q9NRY5; Q05329: GAD2; NbExp=3; IntAct=EBI-10973142, EBI-9304251;
CC Q9NRY5; Q96C03-3: MIEF2; NbExp=3; IntAct=EBI-10973142, EBI-11988931;
CC Q9NRY5; P19404: NDUFV2; NbExp=3; IntAct=EBI-10973142, EBI-713665;
CC Q9NRY5; C9JJ79: PILRA; NbExp=3; IntAct=EBI-10973142, EBI-12117156;
CC Q9NRY5; P43378: PTPN9; NbExp=3; IntAct=EBI-10973142, EBI-742898;
CC Q9NRY5; P61019: RAB2A; NbExp=3; IntAct=EBI-10973142, EBI-752037;
CC Q9NRY5; Q8WUD1: RAB2B; NbExp=3; IntAct=EBI-10973142, EBI-5542466;
CC Q9NRY5; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-10973142, EBI-2623095;
CC Q9NRY5; Q969Z0: TBRG4; NbExp=4; IntAct=EBI-10973142, EBI-702328;
CC Q9NRY5; P49638: TTPA; NbExp=3; IntAct=EBI-10973142, EBI-10210710;
CC -!- SIMILARITY: Belongs to the FAM114 family. {ECO:0000305}.
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DR EMBL; AF159700; AAF76523.1; -; mRNA.
DR EMBL; AK024664; BAB14952.1; -; mRNA.
DR EMBL; AK313331; BAG36135.1; -; mRNA.
DR EMBL; AC010232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471062; EAW61646.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW61647.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW61648.1; -; Genomic_DNA.
DR EMBL; BC011414; AAH11414.1; -; mRNA.
DR CCDS; CCDS4323.1; -.
DR RefSeq; NP_001304922.1; NM_001317993.1.
DR RefSeq; NP_001304923.1; NM_001317994.1.
DR RefSeq; NP_001304924.1; NM_001317995.1.
DR RefSeq; NP_061161.2; NM_018691.3.
DR RefSeq; XP_005268417.1; XM_005268360.4.
DR RefSeq; XP_005268418.1; XM_005268361.4.
DR RefSeq; XP_011535842.1; XM_011537540.2.
DR RefSeq; XP_011535843.1; XM_011537541.2.
DR RefSeq; XP_011535844.1; XM_011537542.2.
DR RefSeq; XP_016864456.1; XM_017008967.1.
DR RefSeq; XP_016864457.1; XM_017008968.1.
DR AlphaFoldDB; Q9NRY5; -.
DR SMR; Q9NRY5; -.
DR BioGRID; 116040; 68.
DR IntAct; Q9NRY5; 28.
DR MINT; Q9NRY5; -.
DR STRING; 9606.ENSP00000341597; -.
DR iPTMnet; Q9NRY5; -.
DR PhosphoSitePlus; Q9NRY5; -.
DR SwissPalm; Q9NRY5; -.
DR BioMuta; FAM114A2; -.
DR DMDM; 296439475; -.
DR REPRODUCTION-2DPAGE; IPI00329662; -.
DR EPD; Q9NRY5; -.
DR jPOST; Q9NRY5; -.
DR MassIVE; Q9NRY5; -.
DR MaxQB; Q9NRY5; -.
DR PaxDb; Q9NRY5; -.
DR PeptideAtlas; Q9NRY5; -.
DR PRIDE; Q9NRY5; -.
DR ProteomicsDB; 82443; -.
DR Antibodypedia; 48470; 72 antibodies from 16 providers.
DR DNASU; 10827; -.
DR Ensembl; ENST00000351797.9; ENSP00000341597.4; ENSG00000055147.19.
DR Ensembl; ENST00000520667.5; ENSP00000430384.1; ENSG00000055147.19.
DR Ensembl; ENST00000522858.5; ENSP00000430489.1; ENSG00000055147.19.
DR GeneID; 10827; -.
DR KEGG; hsa:10827; -.
DR MANE-Select; ENST00000351797.9; ENSP00000341597.4; NM_018691.4; NP_061161.2.
DR UCSC; uc003lvb.5; human.
DR CTD; 10827; -.
DR DisGeNET; 10827; -.
DR GeneCards; FAM114A2; -.
DR HGNC; HGNC:1333; FAM114A2.
DR HPA; ENSG00000055147; Low tissue specificity.
DR neXtProt; NX_Q9NRY5; -.
DR OpenTargets; ENSG00000055147; -.
DR PharmGKB; PA162385716; -.
DR VEuPathDB; HostDB:ENSG00000055147; -.
DR eggNOG; ENOG502QS74; Eukaryota.
DR GeneTree; ENSGT00390000010054; -.
DR InParanoid; Q9NRY5; -.
DR OMA; NTFFAEM; -.
DR OrthoDB; 947469at2759; -.
DR PhylomeDB; Q9NRY5; -.
DR TreeFam; TF324360; -.
DR PathwayCommons; Q9NRY5; -.
DR Reactome; R-HSA-6802952; Signaling by BRAF and RAF1 fusions.
DR SignaLink; Q9NRY5; -.
DR BioGRID-ORCS; 10827; 8 hits in 1084 CRISPR screens.
DR ChiTaRS; FAM114A2; human.
DR GeneWiki; C5orf3; -.
DR GenomeRNAi; 10827; -.
DR Pharos; Q9NRY5; Tdark.
DR PRO; PR:Q9NRY5; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9NRY5; protein.
DR Bgee; ENSG00000055147; Expressed in colonic epithelium and 188 other tissues.
DR ExpressionAtlas; Q9NRY5; baseline and differential.
DR Genevisible; Q9NRY5; HS.
DR GO; GO:0017076; F:purine nucleotide binding; NAS:UniProtKB.
DR InterPro; IPR007998; DUF719.
DR PANTHER; PTHR12842; PTHR12842; 1.
DR Pfam; PF05334; DUF719; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..505
FT /note="Protein FAM114A2"
FT /id="PRO_0000274564"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 268..295
FT /evidence="ECO:0000255"
FT COMPBIAS 44..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 87
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 146
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 209
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT CONFLICT 68
FT /note="P -> S (in Ref. 1; AAF76523)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="G -> S (in Ref. 1; AAF76523, 2; BAB14952 and 5;
FT AAH11414)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 505 AA; 55468 MW; E3991C42F8DCF606 CRC64;
MSDKDDIETP LLTEAAPILE DGNCEPAKNS ESVDQGAKPE SKSEPVVSTR KRPETKPSSD
LETSKVLPIQ DNVSKDVPQT RWGYWGSWGK SILSSASATV ATVGQGISNV IEKAETSLGI
PGPSEISTEV KYVAGETNAK ENENSSPVAG AFGVFSTIST AVQSTGKSVI SGGLDALEFI
GKKTMDVIAE GDPGFKRTKG LMNRNATLSQ VLREAKEKEE IRTSNEVTVE TDKKTHYGLL
FDEFQGLSHL EALEMLSQES EIKVKSILNS LSGEELETLK VELEQLKETF SLAEFCEEEE
EEKKGDEDFT KDITELFSQL HVSSKPEKLA RARNTAHEWI RKSLTKPLAE NEEGEKQSEA
ENTEQVNKNS IEDIHAFAIR SLAELTACSI ELFHKTAALV LHGRKQEVTA IERSQTLSQM
TIVLCKELSS LSKEFTTCLT TAGVKEMADV LNPLITAVFL EASNSASYIQ DAFQLLLPVL
EISLIENKIE SHRHELQGQK PLLEH
