F1142_MOUSE
ID F1142_MOUSE Reviewed; 497 AA.
AC Q8VE88; Q3UE42; Q5QNR1; Q9D310;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Protein FAM114A2;
GN Name=Fam114a2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Pancreas, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8VE88-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8VE88-2; Sequence=VSP_022796;
CC -!- SIMILARITY: Belongs to the FAM114 family. {ECO:0000305}.
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DR EMBL; AK018570; BAB31282.1; -; mRNA.
DR EMBL; AK149763; BAE29069.1; -; mRNA.
DR EMBL; AL672236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC019518; AAH19518.1; -; mRNA.
DR CCDS; CCDS24717.1; -. [Q8VE88-2]
DR CCDS; CCDS48801.1; -. [Q8VE88-1]
DR RefSeq; NP_001162138.1; NM_001168667.1. [Q8VE88-2]
DR RefSeq; NP_001162139.1; NM_001168668.1. [Q8VE88-1]
DR RefSeq; NP_080618.1; NM_026342.3. [Q8VE88-2]
DR RefSeq; XP_006534079.1; XM_006534016.3. [Q8VE88-1]
DR RefSeq; XP_011247496.1; XM_011249194.2. [Q8VE88-1]
DR RefSeq; XP_011247497.1; XM_011249195.2. [Q8VE88-2]
DR AlphaFoldDB; Q8VE88; -.
DR STRING; 10090.ENSMUSP00000104478; -.
DR iPTMnet; Q8VE88; -.
DR PhosphoSitePlus; Q8VE88; -.
DR SwissPalm; Q8VE88; -.
DR EPD; Q8VE88; -.
DR jPOST; Q8VE88; -.
DR MaxQB; Q8VE88; -.
DR PaxDb; Q8VE88; -.
DR PeptideAtlas; Q8VE88; -.
DR PRIDE; Q8VE88; -.
DR ProteomicsDB; 275814; -. [Q8VE88-1]
DR ProteomicsDB; 275815; -. [Q8VE88-2]
DR Antibodypedia; 48470; 72 antibodies from 16 providers.
DR DNASU; 67726; -.
DR Ensembl; ENSMUST00000020831; ENSMUSP00000020831; ENSMUSG00000020523. [Q8VE88-2]
DR Ensembl; ENSMUST00000108850; ENSMUSP00000104478; ENSMUSG00000020523. [Q8VE88-1]
DR GeneID; 67726; -.
DR KEGG; mmu:67726; -.
DR UCSC; uc007izt.2; mouse. [Q8VE88-1]
DR UCSC; uc007izu.2; mouse. [Q8VE88-2]
DR CTD; 10827; -.
DR MGI; MGI:1917629; Fam114a2.
DR VEuPathDB; HostDB:ENSMUSG00000020523; -.
DR eggNOG; ENOG502QS74; Eukaryota.
DR GeneTree; ENSGT00390000010054; -.
DR HOGENOM; CLU_035724_1_0_1; -.
DR InParanoid; Q8VE88; -.
DR OMA; NTFFAEM; -.
DR OrthoDB; 947469at2759; -.
DR PhylomeDB; Q8VE88; -.
DR TreeFam; TF324360; -.
DR BioGRID-ORCS; 67726; 5 hits in 74 CRISPR screens.
DR PRO; PR:Q8VE88; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8VE88; protein.
DR Bgee; ENSMUSG00000020523; Expressed in seminal vesicle and 276 other tissues.
DR Genevisible; Q8VE88; MM.
DR InterPro; IPR007998; DUF719.
DR PANTHER; PTHR12842; PTHR12842; 1.
DR Pfam; PF05334; DUF719; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..497
FT /note="Protein FAM114A2"
FT /id="PRO_0000274565"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 84
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NRY5"
FT MOD_RES 205
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NRY5"
FT VAR_SEQ 61..67
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022796"
FT CONFLICT 14
FT /note="G -> E (in Ref. 3; AAH19518)"
FT /evidence="ECO:0000305"
FT CONFLICT 304
FT /note="N -> D (in Ref. 3; AAH19518)"
FT /evidence="ECO:0000305"
FT CONFLICT 318
FT /note="V -> I (in Ref. 3; AAH19518)"
FT /evidence="ECO:0000305"
FT CONFLICT 438
FT /note="A -> V (in Ref. 3; AAH19518)"
FT /evidence="ECO:0000305"
FT CONFLICT 488
FT /note="S -> P (in Ref. 1; BAE29069)"
FT /evidence="ECO:0000305"
FT CONFLICT 494
FT /note="S -> P (in Ref. 3; AAH19518)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 497 AA; 54045 MW; 9346964631460F6D CRC64;
MSDKDPPESP VVTGVASTLK DENCEPVEKP EDKSQPVVST RKRPETKPSS DLEASALPAQ
VSLAVAKETA SKDVPQTGWG YWGSWGKSLL SSASATVATV GQGISNVIEK AETSLGIPSP
TEISAEVKQA AGEKNAGENG SLLVAAPFGM LSTISTAVQS TGKSVISGGL DALEFIGKKT
MDVIAEGDPG FKRTKGLMNR TSTLSQVLRE AKDKEEQRPS NEVTMETDKK THYGLLFDEF
QGLSHLEALE MLSRESEIKV KSILSSLSGE ELQTTRLELE QLKEVFSLAE FCEEEEEERQ
GDDNFTKEIT DLFAQLHVSS RPEKLARARN TAYKWIRTSL ARPVAEKEEG EKESEAGNTE
EAQKHSIEDI HAFAIRSLAE LTACSIELFH KTAALVLHGQ KQEVTALERS QTLSQMTVML
CKDLASLSKE FTTCLTTAGV REKADVLNPV ITAVFLEASN SASYIQDAFQ LLLPVLQISL
IESKTESSTC EPQSRDL
