ID   F116_DICDI              Reviewed;         715 AA.
AC   Q54VA9;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Protein DENND6 homolog;
GN   ORFNames=DDB_G0280481;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16507593; DOI=10.1242/jcs.02819;
RA   Torija P., Vicente J.J., Rodrigues T.B., Robles A., Cerdan S., Sastre L.,
RA   Calvo R.M., Escalante R.;
RT   "Functional genomics in Dictyostelium: midA, a new conserved protein, is
RT   required for mitochondrial function and development.";
RL   J. Cell Sci. 119:1154-1164(2006).
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC       {ECO:0000269|PubMed:16507593}.
CC   -!- SIMILARITY: Belongs to the DENND6 family. {ECO:0000305}.
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DR   EMBL; AAFI02000036; EAL67219.1; -; Genomic_DNA.
DR   RefSeq; XP_641200.1; XM_636108.1.
DR   AlphaFoldDB; Q54VA9; -.
DR   STRING; 44689.DDB0232144; -.
DR   PaxDb; Q54VA9; -.
DR   EnsemblProtists; EAL67219; EAL67219; DDB_G0280481.
DR   GeneID; 8622581; -.
DR   KEGG; ddi:DDB_G0280481; -.
DR   dictyBase; DDB_G0280481; -.
DR   eggNOG; KOG2432; Eukaryota.
DR   HOGENOM; CLU_017013_1_0_1; -.
DR   InParanoid; Q54VA9; -.
DR   OMA; EANLEHW; -.
DR   PhylomeDB; Q54VA9; -.
DR   Reactome; R-DDI-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:Q54VA9; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   InterPro; IPR018307; ABL9/DENND6_dom.
DR   InterPro; IPR024224; DENND6.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   PANTHER; PTHR13677; PTHR13677; 1.
DR   Pfam; PF09794; Avl9; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..715
FT                   /note="Protein DENND6 homolog"
FT                   /id="PRO_0000356845"
FT   DOMAIN          96..273
FT                   /note="uDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          299..476
FT                   /note="cDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   DOMAIN          478..600
FT                   /note="dDENN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00304"
FT   REGION          269..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..58
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        272..296
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  81261 MW;  8967B2BDCAB14D0F CRC64;
     MNSIIGGTDP LSMIFKEEEI KKQQILLEKE EKEKQEQQQK KLNKDNIFKL EEEGKKLELS
     TKVHIQHPNI STTSDNNSLL DPSNLTLNGK KKKWINSFCI INFDLEIGQV LDYSFPQVNF
     KEEESTNLCF LSFPDSNSHL QGDIIYSFKL KETSSLGNGQ CNFQYGYVFF RQEKDSSISR
     GYLQKSVVLL SDESFVGLFK KVMEIVGPLY FDHGNTLLEV AYQNIMNWPE LKLGQTYELP
     ILGYILTFHV PHTRGTPHII DPVVKQHQLG GGSGGGLSSS PSSSSGGGNI PTSNTTGVSP
     SIWSEMKLVS NLKSIDIYGC FKSFTTKLWM LWELVLLGHP LLVISPNPPM CSDSVLALVS
     LISPLHYCGD YRPYFTIHDT DFHKYTSFSH LSGTRPDDSN NNNNQDDSEY NNNNNNNGIP
     PSILGVTNPF FLKALGNWPN ILTIGTTQQR LGGFKKIKSS LPNIMSKDLL TRHVLDNKEK
     ILSEYKPFIS PDKSVLKKIT ESADDDIINE VLRTHFLQLT QKFLIPLERY FSLLLPLAKT
     ISIFQRPPRL KPFIKEECLN KIMETDERFI IDNKSKEIEL YKQFLDCVNF KQWLDDKRAQ
     AIKHLNILYR KAILDADIHT LLRGKPISTA TDLLKRVEDQ LILEENLFQT SKEIKDKFKS
     HIEIIRQYKN NCDNNNENNN NNILLTSPIK STSLSSIALP PSSTTVTTKT TTTTK