F117A_HUMAN
ID F117A_HUMAN Reviewed; 453 AA.
AC Q9C073; B7Z7Q3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein FAM117A;
DE AltName: Full=C/EBP-induced protein;
GN Name=FAM117A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Bone marrow;
RA Tian Q., Schwartz R.C.;
RT "A novel C/EBP-regulated gene.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Blood, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-67; SER-178; SER-193;
RP SER-201; SER-213; THR-299; THR-354 AND SER-428, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-178 AND SER-193, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9C073-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C073-2; Sequence=VSP_056129;
CC -!- SIMILARITY: Belongs to the FAM117 family. {ECO:0000305}.
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DR EMBL; AF123073; AAK01477.1; -; mRNA.
DR EMBL; AK302376; BAH13689.1; -; mRNA.
DR EMBL; AC015795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC037572; AAH37572.1; -; mRNA.
DR EMBL; BC065199; AAH65199.1; -; mRNA.
DR CCDS; CCDS11553.1; -. [Q9C073-1]
DR RefSeq; NP_110429.1; NM_030802.3. [Q9C073-1]
DR AlphaFoldDB; Q9C073; -.
DR BioGRID; 123522; 16.
DR IntAct; Q9C073; 7.
DR STRING; 9606.ENSP00000240364; -.
DR iPTMnet; Q9C073; -.
DR PhosphoSitePlus; Q9C073; -.
DR BioMuta; FAM117A; -.
DR DMDM; 74733494; -.
DR EPD; Q9C073; -.
DR jPOST; Q9C073; -.
DR MassIVE; Q9C073; -.
DR MaxQB; Q9C073; -.
DR PaxDb; Q9C073; -.
DR PeptideAtlas; Q9C073; -.
DR PRIDE; Q9C073; -.
DR ProteomicsDB; 79962; -. [Q9C073-1]
DR Antibodypedia; 17977; 48 antibodies from 15 providers.
DR DNASU; 81558; -.
DR Ensembl; ENST00000240364.7; ENSP00000240364.2; ENSG00000121104.8. [Q9C073-1]
DR Ensembl; ENST00000513602.5; ENSP00000465808.1; ENSG00000121104.8. [Q9C073-2]
DR GeneID; 81558; -.
DR KEGG; hsa:81558; -.
DR MANE-Select; ENST00000240364.7; ENSP00000240364.2; NM_030802.4; NP_110429.1.
DR UCSC; uc002ipk.4; human. [Q9C073-1]
DR CTD; 81558; -.
DR DisGeNET; 81558; -.
DR GeneCards; FAM117A; -.
DR HGNC; HGNC:24179; FAM117A.
DR HPA; ENSG00000121104; Tissue enhanced (bone).
DR neXtProt; NX_Q9C073; -.
DR OpenTargets; ENSG00000121104; -.
DR PharmGKB; PA145008393; -.
DR VEuPathDB; HostDB:ENSG00000121104; -.
DR eggNOG; ENOG502QW8D; Eukaryota.
DR GeneTree; ENSGT00950000183046; -.
DR HOGENOM; CLU_033432_3_2_1; -.
DR InParanoid; Q9C073; -.
DR OMA; CMHKRSA; -.
DR OrthoDB; 1132072at2759; -.
DR PhylomeDB; Q9C073; -.
DR TreeFam; TF333159; -.
DR PathwayCommons; Q9C073; -.
DR SignaLink; Q9C073; -.
DR BioGRID-ORCS; 81558; 17 hits in 1080 CRISPR screens.
DR ChiTaRS; FAM117A; human.
DR GenomeRNAi; 81558; -.
DR Pharos; Q9C073; Tdark.
DR PRO; PR:Q9C073; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9C073; protein.
DR Bgee; ENSG00000121104; Expressed in trabecular bone tissue and 177 other tissues.
DR ExpressionAtlas; Q9C073; baseline and differential.
DR Genevisible; Q9C073; HS.
DR InterPro; IPR026642; Glcci1/FAM117.
DR PANTHER; PTHR14972; PTHR14972; 1.
DR Pfam; PF15388; FAM117; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..453
FT /note="Protein FAM117A"
FT /id="PRO_0000264988"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 149..175
FT /evidence="ECO:0000255"
FT COMPBIAS 159..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 29
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 67
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 178
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 193
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 201
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 213
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"
FT MOD_RES 299
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 319
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TNF9"
FT MOD_RES 327
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TNF9"
FT MOD_RES 354
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 413
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TNF9"
FT MOD_RES 428
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..272
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056129"
SQ SEQUENCE 453 AA; 48319 MW; 93B83B4E293BBC7E CRC64;
MAGAAAGGRG GGAWGPGRGG AGGLRRGCSP PAPAGSPRAG LQPLRATIPF QLQQPHQRRD
GGGRAASVPC SVAPEKSVCR PQPLQVRRTF SLDTILSSYL LGQWPRDADG AFTCCTNDKA
TQTPLSWQEL EGERASSCAH KRSASWGSTD HRKEISKLKQ QLQRTKLSRS GKEKERGSPL
LGDHAVRGAL RASPPSFPSG SPVLRLSPCL HRSLEGLNQE LEEVFVKEQG EEELLRILDI
PDGHRAPAPP QSGSCDHPLL LLEPGNLASS PSMSLASPQP CGLASHEEHR GAAEELASTP
NDKASSPGHP AFLEDGSPSP VLAFAASPRP NHSYIFKREP PEGCEKVRVF EEATSPGPDL
AFLTSCPDKN KVHFNPTGSA FCPVNLMKPL FPGMGFIFRN CPSNPGSPLP PASPRPPPRK
DPEASKASPL PFEPWQRTPP SEEPVLFQSS LMV
