F117A_MOUSE
ID F117A_MOUSE Reviewed; 451 AA.
AC Q7TNF9; Q3TJJ0; Q3TND5; Q8BJY9;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein FAM117A;
GN Name=Fam117a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, Liver, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-213; SER-318; SER-326
RP AND SER-412, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Kidney, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7TNF9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7TNF9-2; Sequence=VSP_021901;
CC -!- SIMILARITY: Belongs to the FAM117 family. {ECO:0000305}.
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DR EMBL; AK077747; BAC36990.1; -; mRNA.
DR EMBL; AK165378; BAE38154.1; -; mRNA.
DR EMBL; AK167417; BAE39505.1; -; mRNA.
DR EMBL; AL627222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC055690; AAH55690.1; -; mRNA.
DR CCDS; CCDS25276.1; -. [Q7TNF9-1]
DR RefSeq; NP_766131.2; NM_172543.4. [Q7TNF9-1]
DR AlphaFoldDB; Q7TNF9; -.
DR STRING; 10090.ENSMUSP00000049162; -.
DR iPTMnet; Q7TNF9; -.
DR PhosphoSitePlus; Q7TNF9; -.
DR EPD; Q7TNF9; -.
DR jPOST; Q7TNF9; -.
DR MaxQB; Q7TNF9; -.
DR PaxDb; Q7TNF9; -.
DR PeptideAtlas; Q7TNF9; -.
DR PRIDE; Q7TNF9; -.
DR ProteomicsDB; 275958; -. [Q7TNF9-1]
DR ProteomicsDB; 275959; -. [Q7TNF9-2]
DR Antibodypedia; 17977; 48 antibodies from 15 providers.
DR DNASU; 215512; -.
DR Ensembl; ENSMUST00000037502; ENSMUSP00000049162; ENSMUSG00000038893. [Q7TNF9-1]
DR GeneID; 215512; -.
DR KEGG; mmu:215512; -.
DR UCSC; uc007lag.2; mouse. [Q7TNF9-1]
DR CTD; 81558; -.
DR MGI; MGI:2144564; Fam117a.
DR VEuPathDB; HostDB:ENSMUSG00000038893; -.
DR eggNOG; ENOG502QW8D; Eukaryota.
DR GeneTree; ENSGT00950000183046; -.
DR HOGENOM; CLU_033432_3_2_1; -.
DR InParanoid; Q7TNF9; -.
DR OMA; CMHKRSA; -.
DR OrthoDB; 1132072at2759; -.
DR PhylomeDB; Q7TNF9; -.
DR TreeFam; TF333159; -.
DR BioGRID-ORCS; 215512; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Fam117a; mouse.
DR PRO; PR:Q7TNF9; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q7TNF9; protein.
DR Bgee; ENSMUSG00000038893; Expressed in femorotibial joint and 237 other tissues.
DR Genevisible; Q7TNF9; MM.
DR InterPro; IPR026642; Glcci1/FAM117.
DR PANTHER; PTHR14972; PTHR14972; 1.
DR Pfam; PF15388; FAM117; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..451
FT /note="Protein FAM117A"
FT /id="PRO_0000264989"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 149..175
FT /evidence="ECO:0000255"
FT COMPBIAS 164..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 29
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 67
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C073"
FT MOD_RES 193
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C073"
FT MOD_RES 213
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 318
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 326
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 353
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9C073"
FT MOD_RES 412
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 426
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C073"
FT VAR_SEQ 405..451
FT /note="GSPLPTASPRAPRKGPEASKASSLPSEPWQRSPPSEESVLFQSSLVV -> S
FT FPLGL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021901"
FT CONFLICT 10
FT /note="G -> C (in Ref. 1; BAC36990)"
FT /evidence="ECO:0000305"
FT CONFLICT 11..12
FT /note="GG -> VC (in Ref. 1; BAE39505)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 451 AA; 48054 MW; 819D14789017E876 CRC64;
MSGAAAGGRG GGSWGPGRGG AGGLRRGCSP PAPAGSPRVG LQPLRATVPF QLQQPHQRRD
GGGRAASVPC SVAPEKSVCR PQPPQVRRTF SLDTILSSYL LGQWPRDADG AFTCCTNDKA
TQTPLSWQEP EGERASFCMH KRSASWGSTD HRKEITKLKQ QLQRTKLSRS GKEKERSCPV
QGDHAALGAG RASLPSHPPG PPVLRLSPCL HRSLEGLNQE LEEVFVKEQG EEELLRILEV
PDGHRAPAPP QNSSCDHSLL LEPGNLTSSP SVPLASPQPP SQASREEHQG ATEELASIHG
NKASSPGNPA FLEDGSPSPV LAFAASPRPN HSYVFKREPP EGCERVRVFE EATSPGPDLA
FLTSCPDKNK VHFNPTGSAF CPVSLIKPLF PSMGFIFRNC PSSPGSPLPT ASPRAPRKGP
EASKASSLPS EPWQRSPPSE ESVLFQSSLV V
