F117B_MOUSE
ID F117B_MOUSE Reviewed; 584 AA.
AC Q3U3E2; Q68EE3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Protein FAM117B;
DE AltName: Full=Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein homolog;
GN Name=Fam117b; Synonyms=Als2cr13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 150-584.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-444, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-102; SER-340 AND
RP SER-444, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK154812; BAE32846.1; -; mRNA.
DR EMBL; BC080299; AAH80299.2; -; mRNA.
DR CCDS; CCDS14986.1; -.
DR RefSeq; NP_001032814.1; NM_001037725.3.
DR AlphaFoldDB; Q3U3E2; -.
DR SMR; Q3U3E2; -.
DR STRING; 10090.ENSMUSP00000041671; -.
DR iPTMnet; Q3U3E2; -.
DR PhosphoSitePlus; Q3U3E2; -.
DR EPD; Q3U3E2; -.
DR jPOST; Q3U3E2; -.
DR MaxQB; Q3U3E2; -.
DR PaxDb; Q3U3E2; -.
DR PeptideAtlas; Q3U3E2; -.
DR PRIDE; Q3U3E2; -.
DR ProteomicsDB; 275960; -.
DR Antibodypedia; 1012; 142 antibodies from 23 providers.
DR DNASU; 72750; -.
DR Ensembl; ENSMUST00000036540; ENSMUSP00000041671; ENSMUSG00000041040.
DR GeneID; 72750; -.
DR KEGG; mmu:72750; -.
DR UCSC; uc011wlt.2; mouse.
DR CTD; 150864; -.
DR MGI; MGI:1920000; Fam117b.
DR VEuPathDB; HostDB:ENSMUSG00000041040; -.
DR eggNOG; ENOG502QR2I; Eukaryota.
DR GeneTree; ENSGT00950000183046; -.
DR HOGENOM; CLU_033432_0_0_1; -.
DR InParanoid; Q3U3E2; -.
DR OMA; DKTRQPS; -.
DR OrthoDB; 1132072at2759; -.
DR PhylomeDB; Q3U3E2; -.
DR TreeFam; TF333159; -.
DR BioGRID-ORCS; 72750; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Fam117b; mouse.
DR PRO; PR:Q3U3E2; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3U3E2; protein.
DR Bgee; ENSMUSG00000041040; Expressed in animal zygote and 253 other tissues.
DR ExpressionAtlas; Q3U3E2; baseline and differential.
DR Genevisible; Q3U3E2; MM.
DR InterPro; IPR026641; FAM117B.
DR InterPro; IPR026642; Glcci1/FAM117.
DR PANTHER; PTHR14972; PTHR14972; 1.
DR PANTHER; PTHR14972:SF6; PTHR14972:SF6; 1.
DR Pfam; PF15388; FAM117; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..584
FT /note="Protein FAM117B"
FT /id="PRO_0000299534"
FT REGION 1..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..146
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 102
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 206
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1L5"
FT MOD_RES 215
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1L5"
FT MOD_RES 216
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1L5"
FT MOD_RES 268
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1L5"
FT MOD_RES 340
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 386
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1L5"
FT MOD_RES 444
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 452
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6P1L5"
SQ SEQUENCE 584 AA; 61345 MW; 6925098BD41905AA CRC64;
MSQRVRRNGS PTPAGALAGG AVGPPGGPGS RLQPMRATVP FQLKQQQQHG SPTRGGGGGG
NNGGNGGASG PSGGGGSGGP RTASRSTSPT RGGGGSAAAR TSPTVATQTG ASVTSTRGTS
PTRGTAPGAR SSPPRPQPPP PLLGTVSSPS SSPTHLWPSE VIAAPPSARV RHRRRSPEQG
RPSAEKRSPS APVCKAGDKT HPPSSSSSSI IRRTSSLDTL AAPYLAGHWP RDIRGQAAPC
MRDKATQTES AWAEEYEKKK GSHKRSSSWG STEQLKEIAK LRQQLQRSKH SSRHHRDKER
QSPFHGNHAA INQSQAPAPK STLVPAGPIT KSSGSRFRNS VEGLNQEIEI IIKETGEKEE
QLIPQDIPDG HRAPPPLAQR SSSTRSIDTQ TPGGADKGSN NSSRSQSVSP TSFLTISNEG
SEESPCSADD LLADPRDKEN GNNSPLPKYA TSPKPNNSYM FKREPPEGCE RVKVFEECSP
KQLHEIPAFY CPDKNKVNFI PKSGSAFCLV SILKPLLPTP DLTLKGSGHS LTVTTGMTTT
LLQPISMASL STNTEQERVS RGTSTVLPSA SLHAPPEPIE EAEG
