F118A_HUMAN
ID F118A_HUMAN Reviewed; 357 AA.
AC Q9NWS6; B3KWG4; B4DY02; Q5TII5; Q96CY3;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Protein FAM118A;
GN Name=FAM118A; Synonyms=C22orf8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP LEU-129 AND HIS-239.
RC TISSUE=Testis, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS LEU-129
RP AND HIS-239.
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS LEU-129
RP AND HIS-239.
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-311, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q9NWS6; Q96BJ3: AIDA; NbExp=6; IntAct=EBI-8638992, EBI-4401674;
CC Q9NWS6; O00244: ATOX1; NbExp=6; IntAct=EBI-8638992, EBI-10179267;
CC Q9NWS6; Q16543: CDC37; NbExp=3; IntAct=EBI-8638992, EBI-295634;
CC Q9NWS6; Q9UHG0: DCDC2; NbExp=3; IntAct=EBI-8638992, EBI-10303987;
CC Q9NWS6; Q9NWS6: FAM118A; NbExp=4; IntAct=EBI-8638992, EBI-8638992;
CC Q9NWS6; Q9BPY3: FAM118B; NbExp=6; IntAct=EBI-8638992, EBI-726822;
CC Q9NWS6; O76003: GLRX3; NbExp=3; IntAct=EBI-8638992, EBI-374781;
CC Q9NWS6; Q8TBB1: LNX1; NbExp=4; IntAct=EBI-8638992, EBI-739832;
CC Q9NWS6; Q9H8S9: MOB1A; NbExp=3; IntAct=EBI-8638992, EBI-748229;
CC Q9NWS6; Q70IA8: MOB3C; NbExp=4; IntAct=EBI-8638992, EBI-9679267;
CC Q9NWS6; P78317: RNF4; NbExp=3; IntAct=EBI-8638992, EBI-2340927;
CC Q9NWS6; O00560: SDCBP; NbExp=3; IntAct=EBI-8638992, EBI-727004;
CC Q9NWS6; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-8638992, EBI-10180829;
CC Q9NWS6; P57081: WDR4; NbExp=7; IntAct=EBI-8638992, EBI-750427;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NWS6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NWS6-2; Sequence=VSP_056990;
CC -!- SIMILARITY: Belongs to the FAM118 family. {ECO:0000305}.
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DR EMBL; AK000642; BAA91301.1; -; mRNA.
DR EMBL; AK125027; BAG54126.1; -; mRNA.
DR EMBL; AK302205; BAG63564.1; -; mRNA.
DR EMBL; CR456403; CAG30289.1; -; mRNA.
DR EMBL; AL008718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC013696; AAH13696.1; -; mRNA.
DR CCDS; CCDS14065.1; -. [Q9NWS6-1]
DR RefSeq; NP_001098065.1; NM_001104595.1. [Q9NWS6-1]
DR RefSeq; NP_060381.2; NM_017911.2. [Q9NWS6-1]
DR AlphaFoldDB; Q9NWS6; -.
DR SMR; Q9NWS6; -.
DR BioGRID; 120339; 21.
DR IntAct; Q9NWS6; 15.
DR MINT; Q9NWS6; -.
DR STRING; 9606.ENSP00000216214; -.
DR GlyGen; Q9NWS6; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9NWS6; -.
DR PhosphoSitePlus; Q9NWS6; -.
DR BioMuta; FAM118A; -.
DR DMDM; 296434496; -.
DR EPD; Q9NWS6; -.
DR jPOST; Q9NWS6; -.
DR MassIVE; Q9NWS6; -.
DR MaxQB; Q9NWS6; -.
DR PaxDb; Q9NWS6; -.
DR PeptideAtlas; Q9NWS6; -.
DR PRIDE; Q9NWS6; -.
DR ProteomicsDB; 82972; -. [Q9NWS6-1]
DR Antibodypedia; 13685; 58 antibodies from 14 providers.
DR DNASU; 55007; -.
DR Ensembl; ENST00000216214.7; ENSP00000216214.3; ENSG00000100376.12. [Q9NWS6-1]
DR Ensembl; ENST00000441876.7; ENSP00000395892.2; ENSG00000100376.12. [Q9NWS6-1]
DR GeneID; 55007; -.
DR KEGG; hsa:55007; -.
DR MANE-Select; ENST00000441876.7; ENSP00000395892.2; NM_017911.4; NP_060381.2.
DR UCSC; uc003bfz.5; human. [Q9NWS6-1]
DR CTD; 55007; -.
DR DisGeNET; 55007; -.
DR GeneCards; FAM118A; -.
DR HGNC; HGNC:1313; FAM118A.
DR HPA; ENSG00000100376; Low tissue specificity.
DR neXtProt; NX_Q9NWS6; -.
DR OpenTargets; ENSG00000100376; -.
DR PharmGKB; PA25890; -.
DR VEuPathDB; HostDB:ENSG00000100376; -.
DR eggNOG; ENOG502QSNY; Eukaryota.
DR GeneTree; ENSGT00390000010215; -.
DR HOGENOM; CLU_063072_1_0_1; -.
DR InParanoid; Q9NWS6; -.
DR OMA; HRSEQKS; -.
DR OrthoDB; 752035at2759; -.
DR PhylomeDB; Q9NWS6; -.
DR TreeFam; TF332439; -.
DR PathwayCommons; Q9NWS6; -.
DR SignaLink; Q9NWS6; -.
DR BioGRID-ORCS; 55007; 13 hits in 1078 CRISPR screens.
DR ChiTaRS; FAM118A; human.
DR GenomeRNAi; 55007; -.
DR Pharos; Q9NWS6; Tdark.
DR PRO; PR:Q9NWS6; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9NWS6; protein.
DR Bgee; ENSG00000100376; Expressed in right testis and 156 other tissues.
DR ExpressionAtlas; Q9NWS6; baseline and differential.
DR Genevisible; Q9NWS6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR038916; FAM118.
DR InterPro; IPR033353; FAM118A.
DR InterPro; IPR039444; SIR2-like.
DR PANTHER; PTHR28623; PTHR28623; 1.
DR PANTHER; PTHR28623:SF2; PTHR28623:SF2; 1.
DR Pfam; PF13289; SIR2_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..357
FT /note="Protein FAM118A"
FT /id="PRO_0000079572"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 311
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..182
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056990"
FT VARIANT 129
FT /note="V -> L (in dbSNP:rs11556482)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15461802, ECO:0000269|PubMed:15489334"
FT /id="VAR_022808"
FT VARIANT 239
FT /note="R -> H (in dbSNP:rs6007594)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15461802, ECO:0000269|PubMed:15489334"
FT /id="VAR_022809"
FT CONFLICT 195
FT /note="T -> R (in Ref. 4; AAH13696)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 40269 MW; 6BDF8142D3BC1D32 CRC64;
MDSVEKTTNR SEQKSRKFLK SLIRKQPQEL LLVIGTGVSA AVAPGIPALC SWRSCIEAVI
EAAEQLEVLH PGDVAEFRRK VTKDRDLLVV AHDLIRKMSP RTGDAKPSFF QDCLMEVFDD
LEQHIRSPVV LQSILSLMDR GAMVLTTNYD NLLEAFGRRQ NKPMESLDLK DKTKVLEWAR
GHMKYGVLHI HGLYTDPCGV VLDPSGYKDV TQDAEVMEVL QNLYRTKSFL FVGCGETLRD
QIFQALFLYS VPNKVDLEHY MLVLKENEDH FFKHQADMLL HGIKVVSYGD CFDHFPGYVQ
DLATQICKQQ SPDADRVDST TLLGNACQDC AKRKLEENGI EVSKKRTQSD TDDAGGS
