F118A_MOUSE
ID F118A_MOUSE Reviewed; 357 AA.
AC Q91YN1; Q3UP97; Q8C4H6; Q8C5E1;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein FAM118A;
GN Name=Fam118a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Lung, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, FVB/N, and FVB/N-3;
RC TISSUE=Embryonic germ cell, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q91YN1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91YN1-2; Sequence=VSP_014460, VSP_014461;
CC -!- SIMILARITY: Belongs to the FAM118 family. {ECO:0000305}.
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DR EMBL; AK078807; BAC37403.1; -; mRNA.
DR EMBL; AK082151; BAC38423.1; -; mRNA.
DR EMBL; AK143690; BAE25500.1; -; mRNA.
DR EMBL; BC016425; AAH16425.1; -; mRNA.
DR EMBL; BC058794; AAH58794.1; -; mRNA.
DR EMBL; BC066174; AAH66174.1; -; mRNA.
DR CCDS; CCDS27717.1; -. [Q91YN1-1]
DR RefSeq; NP_598511.1; NM_133750.4. [Q91YN1-1]
DR RefSeq; XP_006521546.1; XM_006521483.2.
DR AlphaFoldDB; Q91YN1; -.
DR STRING; 10090.ENSMUSP00000023069; -.
DR iPTMnet; Q91YN1; -.
DR PhosphoSitePlus; Q91YN1; -.
DR EPD; Q91YN1; -.
DR MaxQB; Q91YN1; -.
DR PaxDb; Q91YN1; -.
DR PeptideAtlas; Q91YN1; -.
DR PRIDE; Q91YN1; -.
DR ProteomicsDB; 275961; -. [Q91YN1-1]
DR ProteomicsDB; 275962; -. [Q91YN1-2]
DR Antibodypedia; 13685; 58 antibodies from 14 providers.
DR DNASU; 73225; -.
DR Ensembl; ENSMUST00000023069; ENSMUSP00000023069; ENSMUSG00000022434. [Q91YN1-1]
DR Ensembl; ENSMUST00000229203; ENSMUSP00000154985; ENSMUSG00000022434. [Q91YN1-1]
DR GeneID; 73225; -.
DR KEGG; mmu:73225; -.
DR UCSC; uc007xcu.3; mouse. [Q91YN1-2]
DR UCSC; uc007xcv.2; mouse. [Q91YN1-1]
DR CTD; 55007; -.
DR MGI; MGI:1920475; Fam118a.
DR VEuPathDB; HostDB:ENSMUSG00000022434; -.
DR eggNOG; ENOG502QSNY; Eukaryota.
DR GeneTree; ENSGT00390000010215; -.
DR HOGENOM; CLU_063072_1_0_1; -.
DR InParanoid; Q91YN1; -.
DR OMA; HRSEQKS; -.
DR OrthoDB; 752035at2759; -.
DR PhylomeDB; Q91YN1; -.
DR TreeFam; TF332439; -.
DR BioGRID-ORCS; 73225; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Fam118a; mouse.
DR PRO; PR:Q91YN1; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q91YN1; protein.
DR Bgee; ENSMUSG00000022434; Expressed in ureter smooth muscle and 248 other tissues.
DR Genevisible; Q91YN1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR InterPro; IPR038916; FAM118.
DR InterPro; IPR033353; FAM118A.
DR InterPro; IPR039444; SIR2-like.
DR PANTHER; PTHR28623; PTHR28623; 1.
DR PANTHER; PTHR28623:SF2; PTHR28623:SF2; 1.
DR Pfam; PF13289; SIR2_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..357
FT /note="Protein FAM118A"
FT /id="PRO_0000079573"
FT TRANSMEM 30..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9NWS6"
FT MOD_RES 311
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NWS6"
FT VAR_SEQ 218..250
FT /note="EVLQNLYRTKSFLFVGCGETLRDQIFQALFLYS -> VSLFSLGSGCLFWGT
FT NGGSQPSGCVSQAFWFSG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014460"
FT VAR_SEQ 251..357
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014461"
FT CONFLICT 54
FT /note="S -> R (in Ref. 1; BAC38423)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 40475 MW; 81F5ADE7D4D4FE9A CRC64;
MESVEKTTNR SEQKCRKFLK SLIRKQPQDL LLVIGTGVSA AVAPGIRALC SWRSCIEAVI
EAAEQLEVLH PGDVAEFRRK VMKDRDLLVV AHDLIRKMSP RTGDTKPNFF QDCLMEVFDS
LEQHIQNPVV LRSILSLMDR GTMVLTTNYD NLLEIFGQQQ SKPMESLDLK DKTKVLQWAR
GHIKYGVLHI HGLYTDPCGM VLDPSGYKDV TQDPEVMEVL QNLYRTKSFL FVGCGETLRD
QIFQALFLYS VPNKVDLEHY MVVLKENEDH FFKHQADMLL HGIKVVSYGD CFDLFPGYVQ
DLATQICKQR SPDAERVDST TLLGNACQDC AKRKLEENGI EVTKKVRQSD TDDAGGS
