F118B_HUMAN
ID F118B_HUMAN Reviewed; 351 AA.
AC Q9BPY3; Q9H7B0;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Protein FAM118B;
GN Name=FAM118B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE
RP ANALYSIS] AT SER-9, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE
RP ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=24569877; DOI=10.1242/jcs.143453;
RA Li Y., Fong K.W., Tang M., Han X., Gong Z., Ma W., Hebert M., Songyang Z.,
RA Chen J.;
RT "Fam118B, a newly identified component of Cajal bodies, is required for
RT Cajal body formation, snRNP biogenesis and cell viability.";
RL J. Cell Sci. 127:2029-2039(2014).
CC -!- FUNCTION: May play a role in Cajal bodies formation.
CC {ECO:0000269|PubMed:24569877}.
CC -!- INTERACTION:
CC Q9BPY3; Q9UL15: BAG5; NbExp=3; IntAct=EBI-726822, EBI-356517;
CC Q9BPY3; Q9NWS6: FAM118A; NbExp=6; IntAct=EBI-726822, EBI-8638992;
CC Q9BPY3; Q9BPY3: FAM118B; NbExp=3; IntAct=EBI-726822, EBI-726822;
CC Q9BPY3; Q9BUL8: PDCD10; NbExp=3; IntAct=EBI-726822, EBI-740195;
CC Q9BPY3; O75928-2: PIAS2; NbExp=3; IntAct=EBI-726822, EBI-348567;
CC Q9BPY3; Q9Y4B4: RAD54L2; NbExp=3; IntAct=EBI-726822, EBI-948156;
CC Q9BPY3; O76064: RNF8; NbExp=3; IntAct=EBI-726822, EBI-373337;
CC Q9BPY3; O00560: SDCBP; NbExp=3; IntAct=EBI-726822, EBI-727004;
CC Q9BPY3; P63165: SUMO1; NbExp=3; IntAct=EBI-726822, EBI-80140;
CC Q9BPY3; G2XKQ0: SUMO1P1; NbExp=3; IntAct=EBI-726822, EBI-10175576;
CC -!- SUBCELLULAR LOCATION: Nucleus, Cajal body
CC {ECO:0000269|PubMed:24569877}.
CC -!- MISCELLANEOUS: Overexpression changes the morphology of Cajal bodies,
CC while depletion disrupts the localization of components of Cajal
CC bodies, reduces splicing capacity and inhibits cell proliferation.
CC {ECO:0000269|PubMed:24569877}.
CC -!- SIMILARITY: Belongs to the FAM118 family. {ECO:0000305}.
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DR EMBL; AK024756; BAB14987.1; -; mRNA.
DR EMBL; CR457334; CAG33615.1; -; mRNA.
DR EMBL; BC001340; AAH01340.1; -; mRNA.
DR EMBL; BC001647; AAH01647.1; -; mRNA.
DR CCDS; CCDS8470.1; -.
DR RefSeq; NP_078832.1; NM_024556.3.
DR RefSeq; XP_011541279.1; XM_011542977.2.
DR AlphaFoldDB; Q9BPY3; -.
DR SMR; Q9BPY3; -.
DR BioGRID; 122742; 74.
DR IntAct; Q9BPY3; 48.
DR MINT; Q9BPY3; -.
DR STRING; 9606.ENSP00000433343; -.
DR GlyGen; Q9BPY3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BPY3; -.
DR PhosphoSitePlus; Q9BPY3; -.
DR BioMuta; FAM118B; -.
DR DMDM; 74732801; -.
DR EPD; Q9BPY3; -.
DR jPOST; Q9BPY3; -.
DR MassIVE; Q9BPY3; -.
DR MaxQB; Q9BPY3; -.
DR PaxDb; Q9BPY3; -.
DR PeptideAtlas; Q9BPY3; -.
DR PRIDE; Q9BPY3; -.
DR ProteomicsDB; 78594; -.
DR Antibodypedia; 46048; 160 antibodies from 24 providers.
DR DNASU; 79607; -.
DR Ensembl; ENST00000533050.6; ENSP00000433343.1; ENSG00000197798.9.
DR GeneID; 79607; -.
DR KEGG; hsa:79607; -.
DR MANE-Select; ENST00000533050.6; ENSP00000433343.1; NM_024556.4; NP_078832.1.
DR UCSC; uc001qdf.4; human.
DR CTD; 79607; -.
DR GeneCards; FAM118B; -.
DR HGNC; HGNC:26110; FAM118B.
DR HPA; ENSG00000197798; Low tissue specificity.
DR MIM; 616587; gene.
DR neXtProt; NX_Q9BPY3; -.
DR OpenTargets; ENSG00000197798; -.
DR PharmGKB; PA145008413; -.
DR VEuPathDB; HostDB:ENSG00000197798; -.
DR eggNOG; ENOG502QSNY; Eukaryota.
DR GeneTree; ENSGT00390000010215; -.
DR InParanoid; Q9BPY3; -.
DR OMA; WGKQNEL; -.
DR OrthoDB; 752035at2759; -.
DR PhylomeDB; Q9BPY3; -.
DR TreeFam; TF332439; -.
DR PathwayCommons; Q9BPY3; -.
DR SignaLink; Q9BPY3; -.
DR BioGRID-ORCS; 79607; 7 hits in 1078 CRISPR screens.
DR ChiTaRS; FAM118B; human.
DR GenomeRNAi; 79607; -.
DR Pharos; Q9BPY3; Tdark.
DR PRO; PR:Q9BPY3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9BPY3; protein.
DR Bgee; ENSG00000197798; Expressed in oocyte and 173 other tissues.
DR ExpressionAtlas; Q9BPY3; baseline and differential.
DR Genevisible; Q9BPY3; HS.
DR GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0030576; P:Cajal body organization; IEA:InterPro.
DR InterPro; IPR038916; FAM118.
DR InterPro; IPR033352; FAM118B.
DR InterPro; IPR039444; SIR2-like.
DR PANTHER; PTHR28623; PTHR28623; 1.
DR PANTHER; PTHR28623:SF1; PTHR28623:SF1; 1.
DR Pfam; PF13289; SIR2_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Nucleus; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692"
FT CHAIN 2..351
FT /note="Protein FAM118B"
FT /id="PRO_0000295103"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT CONFLICT 133
FT /note="D -> G (in Ref. 1; BAB14987)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 351 AA; 39499 MW; D298067C1D17E339 CRC64;
MASTGSQASD IDEIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG ISAAVAPQVP
ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL VHVAHDLIQK LSPRTSNVRS
TFFKDCLYEV FDDLESKMED SGKQLLQSVL HLMENGALVL TTNFDNLLEL YAADQGKQLE
SLDLTDEKKV LEWAQEKRKL SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE
NKSFLFLGCG WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV
ISYGDDYADL PEYFKRLTCE ISTRGTSAGM VREGQLNGSS AAHSEIRGCS T
