F118B_MOUSE
ID F118B_MOUSE Reviewed; 351 AA.
AC Q8C569; Q3THR7; Q8BNN4; Q8BT26;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Protein FAM118B;
GN Name=Fam118b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=BALB/cJ, C57BL/6J, and NOD;
RC TISSUE=Bone, Corpus striatum, Embryo, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-11, CLEAVAGE OF
RP INITIATOR METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- FUNCTION: May play a role in Cajal bodies formation.
CC {ECO:0000250|UniProtKB:Q9BPY3}.
CC -!- SUBCELLULAR LOCATION: Nucleus, Cajal body
CC {ECO:0000250|UniProtKB:Q9BPY3}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C569-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C569-2; Sequence=VSP_026730;
CC -!- SIMILARITY: Belongs to the FAM118 family. {ECO:0000305}.
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DR EMBL; AK028018; BAC25701.1; -; mRNA.
DR EMBL; AK079397; BAC37632.1; -; mRNA.
DR EMBL; AK081206; BAC38164.1; -; mRNA.
DR EMBL; AK168168; BAE40129.1; -; mRNA.
DR EMBL; AK169810; BAE41383.1; -; mRNA.
DR EMBL; BC051180; AAH51180.1; -; mRNA.
DR CCDS; CCDS22960.1; -. [Q8C569-2]
DR CCDS; CCDS22961.1; -. [Q8C569-1]
DR RefSeq; NP_001273533.1; NM_001286604.1. [Q8C569-1]
DR RefSeq; NP_780620.1; NM_175411.5. [Q8C569-2]
DR RefSeq; NP_919233.1; NM_194257.2. [Q8C569-1]
DR RefSeq; XP_006510000.1; XM_006509937.3. [Q8C569-1]
DR RefSeq; XP_011240684.1; XM_011242382.2. [Q8C569-1]
DR AlphaFoldDB; Q8C569; -.
DR SMR; Q8C569; -.
DR BioGRID; 224609; 3.
DR STRING; 10090.ENSMUSP00000058377; -.
DR iPTMnet; Q8C569; -.
DR PhosphoSitePlus; Q8C569; -.
DR EPD; Q8C569; -.
DR MaxQB; Q8C569; -.
DR PaxDb; Q8C569; -.
DR PeptideAtlas; Q8C569; -.
DR PRIDE; Q8C569; -.
DR ProteomicsDB; 275816; -. [Q8C569-1]
DR ProteomicsDB; 275817; -. [Q8C569-2]
DR Antibodypedia; 46048; 160 antibodies from 24 providers.
DR DNASU; 109229; -.
DR Ensembl; ENSMUST00000059057; ENSMUSP00000058377; ENSMUSG00000050471. [Q8C569-1]
DR Ensembl; ENSMUST00000063782; ENSMUSP00000066281; ENSMUSG00000050471. [Q8C569-2]
DR Ensembl; ENSMUST00000121564; ENSMUSP00000113537; ENSMUSG00000050471. [Q8C569-1]
DR GeneID; 109229; -.
DR KEGG; mmu:109229; -.
DR UCSC; uc009ota.2; mouse. [Q8C569-1]
DR UCSC; uc009otb.2; mouse. [Q8C569-2]
DR CTD; 79607; -.
DR MGI; MGI:1924483; Fam118b.
DR VEuPathDB; HostDB:ENSMUSG00000050471; -.
DR eggNOG; ENOG502QSNY; Eukaryota.
DR GeneTree; ENSGT00390000010215; -.
DR InParanoid; Q8C569; -.
DR OMA; WGKQNEL; -.
DR OrthoDB; 752035at2759; -.
DR PhylomeDB; Q8C569; -.
DR TreeFam; TF332439; -.
DR BioGRID-ORCS; 109229; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Fam118b; mouse.
DR PRO; PR:Q8C569; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8C569; protein.
DR Bgee; ENSMUSG00000050471; Expressed in spermatocyte and 253 other tissues.
DR ExpressionAtlas; Q8C569; baseline and differential.
DR Genevisible; Q8C569; MM.
DR GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0030576; P:Cajal body organization; IEA:InterPro.
DR InterPro; IPR038916; FAM118.
DR InterPro; IPR033352; FAM118B.
DR InterPro; IPR039444; SIR2-like.
DR PANTHER; PTHR28623; PTHR28623; 1.
DR PANTHER; PTHR28623:SF1; PTHR28623:SF1; 1.
DR Pfam; PF13289; SIR2_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Nucleus; Phosphoprotein;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:23806337"
FT CHAIN 2..351
FT /note="Protein FAM118B"
FT /id="PRO_0000295105"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BPY3"
FT MOD_RES 11
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT VAR_SEQ 114..189
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026730"
FT CONFLICT 194
FT /note="A -> D (in Ref. 1; BAE40129)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 351 AA; 39508 MW; 8082AF895A40FE32 CRC64;
MASTGSQASD KNKIFGFFND GEPPTKKPRK LLPSLKTKKP RELVLVIGTG ISAAVAPQVP
ALKSWKGLIQ ALLDAAIDFD LLEDEESKKF QKCLHEDKNL VHVAHDLIQK LSPRTSNVRS
TFFKDCLYEV FDDLESKMED SGKQLLQSVL HLMENGALVL TTNFDNLLEL YAADQGKQLE
SLDLTDEKKV LEWAQEKRKL SVLHIHGVYT NPSGIVLHPA GYQNVLRNTE VMREIQKLYE
NKSFLFLGCG WTVDDTTFQA LFLEAVKHKS DLEHFMLVRR GDVDEFKKLR ENMLDKGIKV
ISYGNDYADL PEYFKRLTCE ISTRGRSAGM AREGQLNGSS AAHGEIRGCS T
