ID   F11_VACCC               Reviewed;         354 AA.
AC   P21052;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 58.
DE   RecName: Full=Protein F11;
GN   ORFNames=F11L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Stimulates increases in peripheral microtubule dynamics and
CC       may increase the motility of the infected cells, contributing to cell-
CC       to-cell spread of the virus. Seems to inhibit the signaling via the
CC       GTPase RHOA and DIAPH1/mDia (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae F11 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48028.1; -; Genomic_DNA.
DR   PIR; G42507; G42507.
DR   SMR; P21052; -.
DR   Proteomes; UP000008269; Genome.
DR   InterPro; IPR007027; Poxvirus_F11.
DR   Pfam; PF04943; Pox_F11; 1.
DR   PIRSF; PIRSF015981; VAC_F11L; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..354
FT                   /note="Protein F11"
FT                   /id="PRO_0000099498"
SQ   SEQUENCE   354 AA;  39647 MW;  385FA109A50B5715 CRC64;
     MGFCIPLRSK MLKRGSRKSS SILARRPTPK KMNIVTDLEN RLKKNSYIEN TNQGNILMDS
     IFVSTMPVET LFGSYITDDS DDYELKDLLN VTYNIKPVIV PDIKLDAVLD RDGNFRPADC
     FLVKLKHRDG FTKGALYLGH SAGFTATICL KNEGVSGLYI PGTSVIRSNI CQGDTIVSRS
     SRGVQFLPQI GGEAIFLIVS LCPTKKLVET GFVIPEISSN DNAKIAARIL SEKRKDTIAH
     IDTLIQHRQQ LELAYYNSCM LTEFLHYCNS YADTIKESLL KETIQKDINI THTNITTLLN
     ETAKVIKLVK SLVDKEDTDI VNNFITKEIK NCGGVKNRDK IVNSLSLSNL DFRL