ID   F11_VACCW               Reviewed;         348 AA.
AC   Q80HX7;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   02-JUN-2021, entry version 38.
DE   RecName: Full=Protein F11;
GN   OrderedLocusNames=VACWR050; ORFNames=F11L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=18485055; DOI=10.1111/j.1600-0854.2008.00762.x;
RA   Morales I., Carbajal M.A., Bohn S., Holzer D., Kato S.E., Greco F.A.,
RA   Moussatche N., Krijnse Locker J.;
RT   "The vaccinia virus F11L gene product facilitates cell detachment and
RT   promotes migration.";
RL   Traffic 9:1283-1298(2008).
RN   [3]
RP   FUNCTION.
RX   PubMed=18005700; DOI=10.1016/j.chom.2007.04.007;
RA   Arakawa Y., Cordeiro J.V., Way M.;
RT   "F11L-mediated inhibition of RhoA-mDia signaling stimulates microtubule
RT   dynamics during vaccinia virus infection.";
RL   Cell Host Microbe 1:213-226(2007).
CC   -!- FUNCTION: Stimulates increases in peripheral microtubule dynamics and
CC       may increase the motility of the infected cells, contributing to cell-
CC       to-cell spread of the virus. Seems to inhibit the signaling via the
CC       GTPase RHOA and DIAPH1/mDia. {ECO:0000269|PubMed:18005700,
CC       ECO:0000269|PubMed:18485055}.
CC   -!- SIMILARITY: Belongs to the poxviridae F11 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AY243312; AAO89329.1; -; Genomic_DNA.
DR   RefSeq; YP_232932.1; NC_006998.1.
DR   DNASU; 3707507; -.
DR   GeneID; 3707507; -.
DR   KEGG; vg:3707507; -.
DR   Proteomes; UP000000344; Genome.
DR   InterPro; IPR007027; Poxvirus_F11.
DR   Pfam; PF04943; Pox_F11; 1.
DR   PIRSF; PIRSF015981; VAC_F11L; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..348
FT                   /note="Protein F11"
FT                   /id="PRO_0000418528"
SQ   SEQUENCE   348 AA;  39045 MW;  8F07FEC7BCAA9F0E CRC64;
     MGFCIPSRSK MLKRGSRKSS SILARRPTPK KMNIVTDLEN RLKKNSYIEN TNQGNILMDS
     IFVSTMPVET LFGSYITDDS DDYELKDLLN VTYNIKPVIV PDIKLDAVLD RDGNFRPADC
     FLVKLKHRDG FTKGALYLGH SAGFTATICL KNEGVSGLYI PGTSVIRSNI CQGDTIVSRS
     SRGVQFLPQI GGEAIFLIVS LCPTKKLVET GFVIPEISSN DNAKIAARIL SEKRKDTIAH
     INTLIQYRQQ LELAYYNSCM LTEFLHYCNS YAGTIKESLL KETIQKDINI THTNITTLLN
     ETAKVIKLVK SLVDKEDTDI VNNFITKEIK NRDKIVNCLS LSNLDFRL