ID   F11_VAR67               Reviewed;         354 AA.
AC   P0DOP5; P33870;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 6.
DE   RecName: Full=Protein F11;
GN   ORFNames=C15L, F11L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8109158; DOI=10.1016/0168-1702(93)90093-3;
RA   Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V.,
RA   Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of
RT   variola virus India-1967 strain.";
RL   Virus Res. 30:239-258(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Stimulates increases in peripheral microtubule dynamics and
CC       may increase the motility of the infected cells, contributing to cell-
CC       to-cell spread of the virus. Seems to inhibit the signaling via the
CC       GTPase RHOA and DIAPH1/mDia (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae F11 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X69198; CAA48976.1; -; Genomic_DNA.
DR   PIR; F36840; F36840.
DR   RefSeq; NP_042079.1; NC_001611.1.
DR   SMR; P0DOP5; -.
DR   GeneID; 1486571; -.
DR   KEGG; vg:1486571; -.
DR   Proteomes; UP000002060; Genome.
DR   InterPro; IPR007027; Poxvirus_F11.
DR   Pfam; PF04943; Pox_F11; 1.
DR   PIRSF; PIRSF015981; VAC_F11L; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..354
FT                   /note="Protein F11"
FT                   /id="PRO_0000099500"
SQ   SEQUENCE   354 AA;  39758 MW;  F7E8AD7125366260 CRC64;
     MGFCIPLRLK MLKRGSRKFS SMLARRHTPK KMNIVTDLEN RLKKNSYIEN TNQGNILMDS
     IFVSTMSVET LFGSYITDDS DDYELKDLLN VTYNIKPVIV PDIKLDAVLD RDGNFRPADC
     FLVKLKHRDG FTKGALYLGH SAGFTATICL KNEGVSGLYI PGTSVIRTNI CQGDTIVSRS
     SRGVQFLLQI GGEAIFLIVS LCPTKKLVET GFVIPNISSN DNAKIAARIL SEKRKDTITH
     IDTLIQYGQQ LELAYYNSCM LTEFLHYCNL YANTIKESLL KETIQKDINI THTNITTLLN
     ETAKVIKLVK SLVDKEDTDI VNNFITKEIK NCGGVKNRDT IVNSLSLSNL DFYL