ID   F11_VARV                Reviewed;         354 AA.
AC   P0DOP6; P33870;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 11.
DE   RecName: Full=Protein F11;
GN   ORFNames=C15L, F11L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
CC   -!- FUNCTION: Stimulates increases in peripheral microtubule dynamics and
CC       may increase the motility of the infected cells, contributing to cell-
CC       to-cell spread of the virus. Seems to inhibit the signaling via the
CC       GTPase RHOA and DIAPH1/mDia (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae F11 protein family.
CC       {ECO:0000305}.
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DR   EMBL; L22579; AAA60783.1; -; Genomic_DNA.
DR   PIR; T28473; T28473.
DR   RefSeq; NP_042079.1; NC_001611.1.
DR   SMR; P0DOP6; -.
DR   GeneID; 1486571; -.
DR   KEGG; vg:1486571; -.
DR   Proteomes; UP000119805; Genome.
DR   InterPro; IPR007027; Poxvirus_F11.
DR   Pfam; PF04943; Pox_F11; 1.
DR   PIRSF; PIRSF015981; VAC_F11L; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..354
FT                   /note="Protein F11"
FT                   /id="PRO_0000448186"
SQ   SEQUENCE   354 AA;  39758 MW;  F7E8AD7125366260 CRC64;
     MGFCIPLRLK MLKRGSRKFS SMLARRHTPK KMNIVTDLEN RLKKNSYIEN TNQGNILMDS
     IFVSTMSVET LFGSYITDDS DDYELKDLLN VTYNIKPVIV PDIKLDAVLD RDGNFRPADC
     FLVKLKHRDG FTKGALYLGH SAGFTATICL KNEGVSGLYI PGTSVIRTNI CQGDTIVSRS
     SRGVQFLLQI GGEAIFLIVS LCPTKKLVET GFVIPNISSN DNAKIAARIL SEKRKDTITH
     IDTLIQYGQQ LELAYYNSCM LTEFLHYCNL YANTIKESLL KETIQKDINI THTNITTLLN
     ETAKVIKLVK SLVDKEDTDI VNNFITKEIK NCGGVKNRDT IVNSLSLSNL DFYL