F120C_HUMAN
ID F120C_HUMAN Reviewed; 1096 AA.
AC Q9NX05; B2RMT7;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Constitutive coactivator of PPAR-gamma-like protein 2;
DE AltName: Full=Protein FAM120C;
DE AltName: Full=Tumor antigen BJ-HCC-21;
GN Name=FAM120C; Synonyms=CXorf17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANT
RP THR-82.
RC TISSUE=Brain;
RX PubMed=14585507; DOI=10.1016/s0378-1119(03)00770-4;
RA Holden S., Raymond F.L.;
RT "The human gene CXorf17 encodes a member of a novel family of putative
RT transmembrane proteins: cDNA cloning and characterization of CXorf17 and
RT its mouse ortholog orf34.";
RL Gene 318:149-161(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT THR-82.
RA Dong X.-Y., Chen W.-F.;
RT "Cloning and identification of genes which are differentially expressed in
RT carcinoma.";
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT THR-82.
RC TISSUE=Signet-ring cell carcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP THR-82.
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-1042, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NX05-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NX05-2; Sequence=VSP_010519, VSP_010520;
CC -!- TISSUE SPECIFICITY: Expressed at low levels in a number of tissues.
CC {ECO:0000269|PubMed:14585507}.
CC -!- SIMILARITY: Belongs to the constitutive coactivator of PPAR-gamma
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM82751.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=BAA91219.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR EMBL; AY150025; AAO24121.1; -; mRNA.
DR EMBL; AY121803; AAM82751.1; ALT_SEQ; mRNA.
DR EMBL; AK000513; BAA91219.1; ALT_SEQ; mRNA.
DR EMBL; AL589872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z84469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016138; AAH16138.2; -; mRNA.
DR EMBL; BC136413; AAI36414.1; -; mRNA.
DR CCDS; CCDS14356.1; -. [Q9NX05-1]
DR CCDS; CCDS55421.1; -. [Q9NX05-2]
DR RefSeq; NP_060318.4; NM_017848.5.
DR RefSeq; NP_940858.2; NM_198456.2.
DR AlphaFoldDB; Q9NX05; -.
DR BioGRID; 120292; 171.
DR IntAct; Q9NX05; 10.
DR MINT; Q9NX05; -.
DR STRING; 9606.ENSP00000364324; -.
DR iPTMnet; Q9NX05; -.
DR PhosphoSitePlus; Q9NX05; -.
DR BioMuta; FAM120C; -.
DR DMDM; 311033453; -.
DR EPD; Q9NX05; -.
DR jPOST; Q9NX05; -.
DR MassIVE; Q9NX05; -.
DR MaxQB; Q9NX05; -.
DR PaxDb; Q9NX05; -.
DR PeptideAtlas; Q9NX05; -.
DR PRIDE; Q9NX05; -.
DR ProteomicsDB; 83015; -. [Q9NX05-1]
DR ProteomicsDB; 83016; -. [Q9NX05-2]
DR Antibodypedia; 26758; 64 antibodies from 16 providers.
DR DNASU; 54954; -.
DR Ensembl; ENST00000375180.7; ENSP00000364324.2; ENSG00000184083.12.
DR Ensembl; ENST00000477084.1; ENSP00000420718.1; ENSG00000184083.12.
DR GeneID; 54954; -.
DR KEGG; hsa:54954; -.
DR UCSC; uc004dsz.5; human. [Q9NX05-1]
DR CTD; 54954; -.
DR DisGeNET; 54954; -.
DR GeneCards; FAM120C; -.
DR HGNC; HGNC:16949; FAM120C.
DR HPA; ENSG00000184083; Low tissue specificity.
DR MIM; 300741; gene.
DR neXtProt; NX_Q9NX05; -.
DR PharmGKB; PA134932227; -.
DR VEuPathDB; HostDB:ENSG00000184083; -.
DR eggNOG; ENOG502QQNQ; Eukaryota.
DR HOGENOM; CLU_008339_0_0_1; -.
DR InParanoid; Q9NX05; -.
DR OrthoDB; 203269at2759; -.
DR PhylomeDB; Q9NX05; -.
DR TreeFam; TF328642; -.
DR PathwayCommons; Q9NX05; -.
DR SignaLink; Q9NX05; -.
DR BioGRID-ORCS; 54954; 8 hits in 705 CRISPR screens.
DR ChiTaRS; FAM120C; human.
DR GeneWiki; FAM120C_(gene); -.
DR GenomeRNAi; 54954; -.
DR Pharos; Q9NX05; Tbio.
DR PRO; PR:Q9NX05; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9NX05; protein.
DR Bgee; ENSG00000184083; Expressed in inferior vagus X ganglion and 181 other tissues.
DR ExpressionAtlas; Q9NX05; baseline and differential.
DR Genevisible; Q9NX05; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR026784; Coact_PPARg.
DR InterPro; IPR026785; Coact_PPARg-like_2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR15976; PTHR15976; 1.
DR PANTHER; PTHR15976:SF15; PTHR15976:SF15; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Methylation; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..1096
FT /note="Constitutive coactivator of PPAR-gamma-like protein
FT 2"
FT /id="PRO_0000221628"
FT REGION 35..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1013
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1014..1039
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1076
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1096
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 58
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8C3F2"
FT MOD_RES 977
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8C3F2"
FT CROSSLNK 1042
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 234..238
FT /note="VFQSL -> QAAML (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
FT /id="VSP_010519"
FT VAR_SEQ 239..1096
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2"
FT /id="VSP_010520"
FT VARIANT 82
FT /note="I -> T (in dbSNP:rs2495783)"
FT /evidence="ECO:0000269|PubMed:14585507,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.2"
FT /id="VAR_047538"
FT VARIANT 934
FT /note="M -> I (in dbSNP:rs41304786)"
FT /id="VAR_062001"
SQ SEQUENCE 1096 AA; 120588 MW; 0BF2647EF9BFE1F1 CRC64;
MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPTAALA PGAPRAARGS
VPLQPPLPPA ALGAYSGGAG PIRHHHPAHH FHHHGQAQPG LHPPLPPPPP PQLPGARVLV
DAGSALPRLY GGYQTDWVCG GQWNAMLGYL SALCQACAYP GGDGLELVVM FPGGLGKDRL
AEWGRRCQAE RQTAQLIVGH VGNKGTPPPR AWFLPPACLS HCVRLALIRF RVKVFQSLED
HHLEVVAFFR ENGFHGLLAH DSEYALYNIP SYYSSHALKL SWNGKNLTTN QFLMQEVAKQ
LGLKRMNFPI FAALLGNHIL PDEDLAAFHW SLLGPEHPLA SLKVRAHQLV LPPCDVVIKA
VSEYVSSIKD PSNLDVVGKD VFKQSQSRTE DKIERFKKAV EYYSVTTKLS SLPVGPSFLG
FRNNRLGNPP LPRNQVGTIS AGKPMFSHQV PQKVKYPPPF PVGPNSSLLF SSHALGESHA
FSEDPMLQNS PFANWAVSYD SSASQFPNYL PSKASPPLGP DSSHSSSSDG DEPNGASSDH
ITEAFHHQPE WGNPNRDRGS WAQPVDTGVS EASLGDGEPH IPSLLSMSTR NHMDITIPPL
PPVAPEVLRV AEHRHRRGLM YPYIYHVLTK GEIKIPVCIE DECNMELPPA ALLFRSARQY
VYGVLFSLAE TQRKMERLAM RRRLPVEVPS VILKEWSAYK GKSPQTPELV SALTFREWTC
PNLKKLWLGK AVEDKNRRMR AFLACMKSDT PSMLNPANVP THLLLMCCVL RYMVQWPGGR
ILHRHELDTF LAQAVSTQLY EPDRLQELKI EKLDARGIQL AALFMSGVDT ALFANDACGQ
PVPWEHCCPW IYFDGKLFQS KLIKAGRERV SLVELCDGQA DLATKVEKMR QSILEGVNMN
HPPPSALLPS PTFVPPMVPS LYPVSLYSRA MGSMPLPPQG RSRGFAGLHP IPPQGGKLEI
AGMVVGQWAG SRSSRGRGSF GMQVVSVGGP GKGHGKEQTG RGSKGHKKGN KQGSSDGVSK
SLELHQGRSR SQVNGNSGAL IKEEKSDHRL PAPSQCALSR DSNECNNGNR YLPMNNREKN
HLQEQKLETV AQRKED
