F120C_MOUSE
ID F120C_MOUSE Reviewed; 1091 AA.
AC Q8C3F2; Q3U0F6;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Constitutive coactivator of PPAR-gamma-like protein 2;
DE AltName: Full=Protein FAM120C;
GN Name=Fam120c; Synonyms=ORF34;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=14585507; DOI=10.1016/s0378-1119(03)00770-4;
RA Holden S., Raymond F.L.;
RT "The human gene CXorf17 encodes a member of a novel family of putative
RT transmembrane proteins: cDNA cloning and characterization of CXorf17 and
RT its mouse ortholog orf34.";
RL Gene 318:149-161(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Head, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Liver, Lung, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-57 AND ARG-972, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8C3F2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C3F2-2; Sequence=VSP_010521, VSP_010522;
CC Name=3;
CC IsoId=Q8C3F2-3; Sequence=VSP_010523, VSP_010524;
CC -!- SIMILARITY: Belongs to the constitutive coactivator of PPAR-gamma
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC39601.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY150023; AAO24119.1; -; mRNA.
DR EMBL; AY150024; AAO24120.1; -; mRNA.
DR EMBL; AK086058; BAC39601.1; ALT_INIT; mRNA.
DR EMBL; AK156920; BAE33898.1; -; mRNA.
DR EMBL; AL662922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL807396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137973; AAI37974.1; -; mRNA.
DR CCDS; CCDS41175.1; -. [Q8C3F2-1]
DR RefSeq; NP_932773.2; NM_198105.2. [Q8C3F2-1]
DR AlphaFoldDB; Q8C3F2; -.
DR BioGRID; 228896; 7.
DR IntAct; Q8C3F2; 4.
DR MINT; Q8C3F2; -.
DR STRING; 10090.ENSMUSP00000073082; -.
DR iPTMnet; Q8C3F2; -.
DR PhosphoSitePlus; Q8C3F2; -.
DR SwissPalm; Q8C3F2; -.
DR EPD; Q8C3F2; -.
DR MaxQB; Q8C3F2; -.
DR PaxDb; Q8C3F2; -.
DR PeptideAtlas; Q8C3F2; -.
DR PRIDE; Q8C3F2; -.
DR ProteomicsDB; 275818; -. [Q8C3F2-1]
DR ProteomicsDB; 275819; -. [Q8C3F2-2]
DR ProteomicsDB; 275820; -. [Q8C3F2-3]
DR Antibodypedia; 26758; 64 antibodies from 16 providers.
DR DNASU; 207375; -.
DR Ensembl; ENSMUST00000073364; ENSMUSP00000073082; ENSMUSG00000025262. [Q8C3F2-1]
DR GeneID; 207375; -.
DR KEGG; mmu:207375; -.
DR UCSC; uc009upb.1; mouse. [Q8C3F2-2]
DR UCSC; uc009upc.1; mouse. [Q8C3F2-1]
DR CTD; 54954; -.
DR MGI; MGI:2387687; Fam120c.
DR VEuPathDB; HostDB:ENSMUSG00000025262; -.
DR eggNOG; ENOG502QQNQ; Eukaryota.
DR GeneTree; ENSGT00530000063168; -.
DR HOGENOM; CLU_008339_0_0_1; -.
DR InParanoid; Q8C3F2; -.
DR OMA; SRDSNVC; -.
DR PhylomeDB; Q8C3F2; -.
DR TreeFam; TF328642; -.
DR BioGRID-ORCS; 207375; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Fam120c; mouse.
DR PRO; PR:Q8C3F2; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8C3F2; protein.
DR Bgee; ENSMUSG00000025262; Expressed in humerus cartilage element and 202 other tissues.
DR Genevisible; Q8C3F2; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR026784; Coact_PPARg.
DR InterPro; IPR026785; Coact_PPARg-like_2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR15976; PTHR15976; 1.
DR PANTHER; PTHR15976:SF15; PTHR15976:SF15; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Reference proteome.
FT CHAIN 1..1091
FT /note="Constitutive coactivator of PPAR-gamma-like protein
FT 2"
FT /id="PRO_0000221629"
FT REGION 35..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..71
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1008
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 57
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 972
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT VAR_SEQ 231..236
FT /note="FQSLED -> REGLDF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010521"
FT VAR_SEQ 237..1091
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010522"
FT VAR_SEQ 989..997
FT /note="HGKEQAGRG -> YVPECVGMS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14585507"
FT /id="VSP_010523"
FT VAR_SEQ 998..1091
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14585507"
FT /id="VSP_010524"
FT CONFLICT 241
FT /note="V -> M (in Ref. 1; AAO24120)"
FT /evidence="ECO:0000305"
FT CONFLICT 730
FT /note="K -> R (in Ref. 1; AAO24119)"
FT /evidence="ECO:0000305"
FT CONFLICT 874
FT /note="Q -> R (in Ref. 1; AAO24120)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1091 AA; 119718 MW; 765E9226F3DFA344 CRC64;
MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPAALAP GAPRITRGSA
PLPPPPLPPA AFGAYSGGAG PSRHHHPAHH FHHHGQAPPG LHPPPPPPLP GARVLVDAGS
ALPRLYGGYQ TDWVCGGQWN AMLGYLSALC QACAYPGGDG LELVVMFPGG LGKDRLAEWG
RRCQAERQTA QLIVGHVGNK GTPPPRAWFL PPACLSHCVR LALIRFRVKV FQSLEDHHLE
VVAFFRENGF HGLLAHDSEY ALYNIPSYYS SHALKLSWNG KNLTTNQFLM QEVAKQLGLK
RMNFPIFAAL LGNHILPDED LAAFHWSLLG PEHPLASLKV RAHQLVLPPC DVVIKAVSEY
VSSIKDPSNL DVVGKDVFKQ SQSRTEDKIE RFKKAVEYYS VTTKLSSLPV GPSFLGFRNN
RLGNPPLPRN QMGPISPGKP MFSRQVPQKM KYPPPFPMGP NSSLLFSHSV GESHAFSEDA
MLQDNSFANW AVSYDSNTSQ FPNCLTSKTS PPLGPDSSHS SSSDGDEANG AGSEQITEAV
QQQPGWEDPN GDRGAWGQPA DAGVSETTVA ESEPHIPSLL SMSTRNHMDI TIPPLPPVAP
EVLRVAEHRH RRGLMYPYIY HVLTKGEIKI PVCIEDECNM ELPPAALLFR SARQYVYGVL
FSLAETQRKM ERLAIRRRLP MEVPSVILKE WSAYKGKSPQ TPELVSALTF REWTCPNLKK
LWLGKAVEDK NRRMRAFLAC MKSDTPSMLN PANVPTHLLL MCCVLRYMVQ WPGGRILHRH
ELDTFLAQAV STQLYEPDQL QELKIEKLDA RGIQLAALFM SGVDTALFAN DACGQPVPWE
HCCPWIYFDG KLFQSKLIKA GRERVSLVEL CDGQADLASK VEKMRQSILE GVNMNHPPPS
ALLPSPTFVP PMVPSLYPVS LYSRAMGSFP PPPQARSRGF AGLHPIPPQG GKLEIAGMVV
GQWAGSRSSR SRGSFGMQVV SVGGPGKGHG KEQAGRGSKG HKKGNKQGSS DVISKAVELH
QSRARSQVNG NNGTLIVEEK SDPLPAPSQC ALSRDSNECN NSDDHCLPVK NGEKNHVPEQ
ELEAVAQQKE E
