F120S_HUMAN
ID F120S_HUMAN Reviewed; 256 AA.
AC Q5T036; A6NN20;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Uncharacterized protein FAM120AOS {ECO:0000305};
DE AltName: Full=FAM120A opposite strand protein {ECO:0000305};
GN Name=FAM120AOS; Synonyms=C9orf10OS;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PHE-22 AND GLU-241.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- INTERACTION:
CC Q5T036; Q99750: MDFI; NbExp=3; IntAct=EBI-12420808, EBI-724076;
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DR EMBL; AK056096; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL583839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL353629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS6705.1; -.
DR RefSeq; NP_942138.2; NM_198841.2.
DR AlphaFoldDB; Q5T036; -.
DR BioGRID; 127664; 24.
DR IntAct; Q5T036; 1.
DR STRING; 9606.ENSP00000364561; -.
DR iPTMnet; Q5T036; -.
DR PhosphoSitePlus; Q5T036; -.
DR BioMuta; FAM120AOS; -.
DR PaxDb; Q5T036; -.
DR PeptideAtlas; Q5T036; -.
DR PRIDE; Q5T036; -.
DR ProteomicsDB; 64123; -.
DR Antibodypedia; 54979; 5 antibodies from 5 providers.
DR DNASU; 158293; -.
DR Ensembl; ENST00000375412.11; ENSP00000364561.5; ENSG00000188938.17.
DR GeneID; 158293; -.
DR KEGG; hsa:158293; -.
DR MANE-Select; ENST00000375412.11; ENSP00000364561.5; NM_198841.4; NP_942138.2.
DR UCSC; uc004atu.5; human.
DR CTD; 158293; -.
DR DisGeNET; 158293; -.
DR GeneCards; FAM120AOS; -.
DR HGNC; HGNC:23389; FAM120AOS.
DR HPA; ENSG00000188938; Low tissue specificity.
DR neXtProt; NX_Q5T036; -.
DR OpenTargets; ENSG00000188938; -.
DR PharmGKB; PA134893278; -.
DR VEuPathDB; HostDB:ENSG00000188938; -.
DR eggNOG; ENOG502TEJ0; Eukaryota.
DR GeneTree; ENSGT00390000001747; -.
DR HOGENOM; CLU_1111099_0_0_1; -.
DR InParanoid; Q5T036; -.
DR OMA; TVASEFW; -.
DR OrthoDB; 1070849at2759; -.
DR PhylomeDB; Q5T036; -.
DR TreeFam; TF338583; -.
DR PathwayCommons; Q5T036; -.
DR SignaLink; Q5T036; -.
DR BioGRID-ORCS; 158293; 11 hits in 1077 CRISPR screens.
DR ChiTaRS; FAM120AOS; human.
DR GenomeRNAi; 158293; -.
DR Pharos; Q5T036; Tdark.
DR PRO; PR:Q5T036; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5T036; protein.
DR Bgee; ENSG00000188938; Expressed in cardiac muscle of right atrium and 189 other tissues.
DR ExpressionAtlas; Q5T036; baseline and differential.
DR Genevisible; Q5T036; HS.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..256
FT /note="Uncharacterized protein FAM120AOS"
FT /id="PRO_0000337248"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 22
FT /note="L -> F (in dbSNP:rs1055710)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_043677"
FT VARIANT 241
FT /note="K -> E (in dbSNP:rs10821128)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_043678"
SQ SEQUENCE 256 AA; 27929 MW; 1BEA53331BA94241 CRC64;
MGKTKDIGDD DTVASEFWSG ALSQPSSVPT RPRTPNRDSW RRAWAARGLH PRPSILQPGP
ARLSRARAGG TRCPQRRHGR ATFCALGRGI GVRRGPGPRP ARIPGLTLTW KRMSARRMQW
AMQTGGRNQT FGGGVPLFWT WLTICCAVWR SLPCRLTHSC SRAFSSAPLK KTKSSMLPPK
QALASAARNL CRGAGCNRQA VAGQLLPSTW SLHAHGLAKE APILPVKKIS RSCSVNNKVS
KKTTKPPTLR SFLSPI
