F124B_HUMAN
ID F124B_HUMAN Reviewed; 455 AA.
AC Q9H5Z6; A6NNC7; Q8NBZ4; Q8TAV7;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein FAM124B;
GN Name=FAM124B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 92-455 (ISOFORM 2).
RC TISSUE=Placenta, and Umbilical vein endothelial cell;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INTERACTION WITH CHD7 AND CHD8, SUBCELLULAR LOCATION, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=23285124; DOI=10.1371/journal.pone.0052640;
RA Batsukh T., Schulz Y., Wolf S., Rabe T.I., Oellerich T., Urlaub H.,
RA Schaefer I.M., Pauli S.;
RT "Identification and characterization of FAM124B as a novel component of a
RT CHD7 and CHD8 containing complex.";
RL PLoS ONE 7:E52640-E52640(2012).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SUBUNIT: Interacts with CHD7 and CHD8. {ECO:0000269|PubMed:23285124}.
CC -!- INTERACTION:
CC Q9H5Z6; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-741626, EBI-10173507;
CC Q9H5Z6; Q96CA5: BIRC7; NbExp=3; IntAct=EBI-741626, EBI-517623;
CC Q9H5Z6; Q9H257: CARD9; NbExp=3; IntAct=EBI-741626, EBI-751319;
CC Q9H5Z6; Q08379: GOLGA2; NbExp=3; IntAct=EBI-741626, EBI-618309;
CC Q9H5Z6; Q8NC69: KCTD6; NbExp=3; IntAct=EBI-741626, EBI-2511344;
CC Q9H5Z6; Q7L273: KCTD9; NbExp=3; IntAct=EBI-741626, EBI-4397613;
CC Q9H5Z6; Q8N8K9: KIAA1958; NbExp=3; IntAct=EBI-741626, EBI-10181113;
CC Q9H5Z6; P08727: KRT19; NbExp=3; IntAct=EBI-741626, EBI-742756;
CC Q9H5Z6; Q15323: KRT31; NbExp=3; IntAct=EBI-741626, EBI-948001;
CC Q9H5Z6; Q6A162: KRT40; NbExp=3; IntAct=EBI-741626, EBI-10171697;
CC Q9H5Z6; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-741626, EBI-10172290;
CC Q9H5Z6; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-741626, EBI-10172052;
CC Q9H5Z6; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-741626, EBI-3958099;
CC Q9H5Z6; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-741626, EBI-741037;
CC Q9H5Z6; Q99750: MDFI; NbExp=4; IntAct=EBI-741626, EBI-724076;
CC Q9H5Z6; Q13064: MKRN3; NbExp=3; IntAct=EBI-741626, EBI-2340269;
CC Q9H5Z6; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-741626, EBI-945833;
CC Q9H5Z6; Q93062: RBPMS; NbExp=3; IntAct=EBI-741626, EBI-740322;
CC Q9H5Z6; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-741626, EBI-726876;
CC Q9H5Z6; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-741626, EBI-2212028;
CC Q9H5Z6; P15884: TCF4; NbExp=3; IntAct=EBI-741626, EBI-533224;
CC Q9H5Z6; Q08117: TLE5; NbExp=3; IntAct=EBI-741626, EBI-717810;
CC Q9H5Z6; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-741626, EBI-2130429;
CC Q9H5Z6; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-741626, EBI-739895;
CC Q9H5Z6-2; Q8IZP0-5: ABI1; NbExp=3; IntAct=EBI-11986315, EBI-11743294;
CC Q9H5Z6-2; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-11986315, EBI-742038;
CC Q9H5Z6-2; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-11986315, EBI-11519926;
CC Q9H5Z6-2; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-11986315, EBI-2548012;
CC Q9H5Z6-2; Q494R4-2: CCDC153; NbExp=3; IntAct=EBI-11986315, EBI-11974185;
CC Q9H5Z6-2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11986315, EBI-3867333;
CC Q9H5Z6-2; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-11986315, EBI-2349927;
CC Q9H5Z6-2; Q9NQ30: ESM1; NbExp=3; IntAct=EBI-11986315, EBI-12260294;
CC Q9H5Z6-2; O75420: GIGYF1; NbExp=3; IntAct=EBI-11986315, EBI-947774;
CC Q9H5Z6-2; Q5VSY0: GKAP1; NbExp=3; IntAct=EBI-11986315, EBI-743722;
CC Q9H5Z6-2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-11986315, EBI-618309;
CC Q9H5Z6-2; Q96D09: GPRASP2; NbExp=3; IntAct=EBI-11986315, EBI-473189;
CC Q9H5Z6-2; Q14451-3: GRB7; NbExp=3; IntAct=EBI-11986315, EBI-11991632;
CC Q9H5Z6-2; O75031: HSF2BP; NbExp=3; IntAct=EBI-11986315, EBI-7116203;
CC Q9H5Z6-2; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-11986315, EBI-8638439;
CC Q9H5Z6-2; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-11986315, EBI-747204;
CC Q9H5Z6-2; Q86U28: ISCA2; NbExp=3; IntAct=EBI-11986315, EBI-10258659;
CC Q9H5Z6-2; Q15323: KRT31; NbExp=3; IntAct=EBI-11986315, EBI-948001;
CC Q9H5Z6-2; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-11986315, EBI-11741292;
CC Q9H5Z6-2; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-11986315, EBI-1043191;
CC Q9H5Z6-2; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-11986315, EBI-12039345;
CC Q9H5Z6-2; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-11986315, EBI-12516603;
CC Q9H5Z6-2; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-11986315, EBI-2548751;
CC Q9H5Z6-2; Q5JR59-3: MTUS2; NbExp=4; IntAct=EBI-11986315, EBI-11522433;
CC Q9H5Z6-2; P13349: MYF5; NbExp=3; IntAct=EBI-11986315, EBI-17491620;
CC Q9H5Z6-2; O95544: NADK; NbExp=3; IntAct=EBI-11986315, EBI-743949;
CC Q9H5Z6-2; Q86UC2: RSPH3; NbExp=3; IntAct=EBI-11986315, EBI-6873025;
CC Q9H5Z6-2; Q6ZU15: SEPTIN14; NbExp=3; IntAct=EBI-11986315, EBI-2009297;
CC Q9H5Z6-2; O14492-2: SH2B2; NbExp=3; IntAct=EBI-11986315, EBI-19952306;
CC Q9H5Z6-2; Q8TDD2: SP7; NbExp=3; IntAct=EBI-11986315, EBI-10713842;
CC Q9H5Z6-2; Q08117-2: TLE5; NbExp=3; IntAct=EBI-11986315, EBI-11741437;
CC Q9H5Z6-2; Q12933: TRAF2; NbExp=3; IntAct=EBI-11986315, EBI-355744;
CC Q9H5Z6-2; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-11986315, EBI-5235829;
CC Q9H5Z6-2; Q9BZR9: TRIM8; NbExp=3; IntAct=EBI-11986315, EBI-2340370;
CC Q9H5Z6-2; Q9C026: TRIM9; NbExp=3; IntAct=EBI-11986315, EBI-720828;
CC Q9H5Z6-2; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-11986315, EBI-11975223;
CC Q9H5Z6-2; Q9BRX9: WDR83; NbExp=3; IntAct=EBI-11986315, EBI-7705033;
CC Q9H5Z6-2; O96006: ZBED1; NbExp=3; IntAct=EBI-11986315, EBI-740037;
CC Q9H5Z6-2; Q9UC07-2: ZNF69; NbExp=3; IntAct=EBI-11986315, EBI-12310821;
CC Q9H5Z6-2; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-11986315, EBI-10251462;
CC Q9H5Z6-2; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-11986315, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23285124}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H5Z6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H5Z6-2; Sequence=VSP_025042, VSP_025043;
CC -!- SIMILARITY: Belongs to the FAM124 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15471.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK026399; BAB15471.1; ALT_FRAME; mRNA.
DR EMBL; AK075126; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC008072; AAY14842.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70827.1; -; Genomic_DNA.
DR EMBL; BC025754; AAH25754.1; -; mRNA.
DR CCDS; CCDS2461.1; -. [Q9H5Z6-2]
DR CCDS; CCDS46527.1; -. [Q9H5Z6-1]
DR RefSeq; NP_001116251.1; NM_001122779.1. [Q9H5Z6-1]
DR RefSeq; NP_079061.2; NM_024785.2. [Q9H5Z6-2]
DR AlphaFoldDB; Q9H5Z6; -.
DR SMR; Q9H5Z6; -.
DR BioGRID; 122934; 73.
DR IntAct; Q9H5Z6; 68.
DR STRING; 9606.ENSP00000386895; -.
DR iPTMnet; Q9H5Z6; -.
DR PhosphoSitePlus; Q9H5Z6; -.
DR BioMuta; FAM124B; -.
DR DMDM; 221222523; -.
DR MassIVE; Q9H5Z6; -.
DR PaxDb; Q9H5Z6; -.
DR PeptideAtlas; Q9H5Z6; -.
DR PRIDE; Q9H5Z6; -.
DR Antibodypedia; 47677; 72 antibodies from 16 providers.
DR DNASU; 79843; -.
DR Ensembl; ENST00000243806.2; ENSP00000243806.2; ENSG00000124019.10. [Q9H5Z6-2]
DR Ensembl; ENST00000389874.3; ENSP00000374524.3; ENSG00000124019.10. [Q9H5Z6-2]
DR Ensembl; ENST00000409685.4; ENSP00000386895.3; ENSG00000124019.10. [Q9H5Z6-1]
DR GeneID; 79843; -.
DR KEGG; hsa:79843; -.
DR MANE-Select; ENST00000409685.4; ENSP00000386895.3; NM_001122779.2; NP_001116251.1.
DR UCSC; uc002vnw.3; human. [Q9H5Z6-1]
DR CTD; 79843; -.
DR DisGeNET; 79843; -.
DR GeneCards; FAM124B; -.
DR HGNC; HGNC:26224; FAM124B.
DR HPA; ENSG00000124019; Tissue enhanced (placenta).
DR MIM; 618403; gene.
DR neXtProt; NX_Q9H5Z6; -.
DR OpenTargets; ENSG00000124019; -.
DR PharmGKB; PA162385815; -.
DR VEuPathDB; HostDB:ENSG00000124019; -.
DR eggNOG; ENOG502QUJG; Eukaryota.
DR GeneTree; ENSGT00590000083134; -.
DR HOGENOM; CLU_070689_0_0_1; -.
DR InParanoid; Q9H5Z6; -.
DR OMA; EWICPDV; -.
DR OrthoDB; 626528at2759; -.
DR PhylomeDB; Q9H5Z6; -.
DR TreeFam; TF328699; -.
DR PathwayCommons; Q9H5Z6; -.
DR SignaLink; Q9H5Z6; -.
DR BioGRID-ORCS; 79843; 24 hits in 1079 CRISPR screens.
DR GenomeRNAi; 79843; -.
DR Pharos; Q9H5Z6; Tdark.
DR PRO; PR:Q9H5Z6; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9H5Z6; protein.
DR Bgee; ENSG00000124019; Expressed in placenta and 101 other tissues.
DR Genevisible; Q9H5Z6; HS.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR029380; FAM124.
DR InterPro; IPR046365; FAM124_dom.
DR PANTHER; PTHR14715; PTHR14715; 1.
DR Pfam; PF15067; FAM124; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..455
FT /note="Protein FAM124B"
FT /id="PRO_0000286384"
FT REGION 270..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 245..272
FT /note="VQLNPELGVKNGILGAGMLPLGSRLTSV -> RWESSSVAQTRVRWCHHSSL
FT RSSPSGFK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_025042"
FT VAR_SEQ 273..455
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_025043"
FT VARIANT 257
FT /note="I -> T (in dbSNP:rs3738954)"
FT /id="VAR_060151"
FT CONFLICT 62..64
FT /note="SRF -> YRL (in Ref. 1; BAB15471)"
FT /evidence="ECO:0000305"
FT CONFLICT 264
FT /note="P -> S (in Ref. 1; BAB15471)"
FT /evidence="ECO:0000305"
FT CONFLICT 429
FT /note="R -> G (in Ref. 1; BAB15471)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 455 AA; 50961 MW; 730A6BE5893E6DE5 CRC64;
MDETQGPLAM TVHLLANSGH GSLLQRTLDQ LLDCICPEVR LFQVSERASP VKYCEKSHSK
RSRFPGMSVL LFLHESPGED RLFRVLDSLQ HSPWQCYPTQ DTRGRLCPYF FANQEFYSLD
SQLPIWGVRQ VHCGSEILRV TLYCSFDNYE DAIRLYEMIL QREATLQKSN FCFFVLYASK
SFALQLSLKQ LPPGMSVDPK ESSVLQFKVQ EIGQLVPLLP NPCMPISSTR WQTQDYDGNK
ILLQVQLNPE LGVKNGILGA GMLPLGSRLT SVSAKRTSEP RSQRNQGKRS QGHSLELPEP
SGSPTSDRCA GTSWKSPGRS FQVSSPAMGA HLHLSSHHLE SGARMKVLNR ENSFQKLEAE
TNVDTGLTII NSEPRQTYFG GFPRDLQTSQ PPFCLPASSL GVATSKNNSV LKERVSPLPL
AGQRDLGTRK TISECLLHLQ VQGEEKEEDE EEFFI
