F124B_MOUSE
ID F124B_MOUSE Reviewed; 456 AA.
AC Q8BLQ0;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Protein FAM124B;
GN Name=Fam124b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=23285124; DOI=10.1371/journal.pone.0052640;
RA Batsukh T., Schulz Y., Wolf S., Rabe T.I., Oellerich T., Urlaub H.,
RA Schaefer I.M., Pauli S.;
RT "Identification and characterization of FAM124B as a novel component of a
RT CHD7 and CHD8 containing complex.";
RL PLoS ONE 7:E52640-E52640(2012).
CC -!- SUBUNIT: Interacts with CHD7 and CHD8. {ECO:0000250|UniProtKB:Q9H5Z6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23285124}.
CC -!- TISSUE SPECIFICITY: Expressed strongly in lung, at slightly lower
CC levels in heart, kidney, brain and testis, and weakly in liver (at
CC protein level). In brain, highly expressed in cortex, hippocampus,
CC dentate gyrus, caudate putamen and cerebellum (at protein level).
CC {ECO:0000269|PubMed:23285124}.
CC -!- DEVELOPMENTAL STAGE: At embryonic stage 12.5 dpc, detected in a wide
CC range of tissues including brain, heart, lung, cochlea, dorsal root
CC ganglia, and liver (at protein level). {ECO:0000269|PubMed:23285124}.
CC -!- SIMILARITY: Belongs to the FAM124 family. {ECO:0000305}.
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DR EMBL; AK043867; BAC31685.1; -; mRNA.
DR CCDS; CCDS15093.1; -.
DR RefSeq; NP_775601.1; NM_173425.3.
DR AlphaFoldDB; Q8BLQ0; -.
DR STRING; 10090.ENSMUSP00000052208; -.
DR iPTMnet; Q8BLQ0; -.
DR PhosphoSitePlus; Q8BLQ0; -.
DR PaxDb; Q8BLQ0; -.
DR PRIDE; Q8BLQ0; -.
DR ProteomicsDB; 271516; -.
DR Antibodypedia; 47677; 72 antibodies from 16 providers.
DR DNASU; 241128; -.
DR Ensembl; ENSMUST00000058748; ENSMUSP00000052208; ENSMUSG00000043230.
DR GeneID; 241128; -.
DR KEGG; mmu:241128; -.
DR UCSC; uc007brb.2; mouse.
DR CTD; 79843; -.
DR MGI; MGI:3026880; Fam124b.
DR VEuPathDB; HostDB:ENSMUSG00000043230; -.
DR eggNOG; ENOG502QUJG; Eukaryota.
DR GeneTree; ENSGT00590000083134; -.
DR HOGENOM; CLU_037215_0_0_1; -.
DR InParanoid; Q8BLQ0; -.
DR OMA; PWQCYPA; -.
DR OrthoDB; 626528at2759; -.
DR PhylomeDB; Q8BLQ0; -.
DR TreeFam; TF328699; -.
DR BioGRID-ORCS; 241128; 1 hit in 70 CRISPR screens.
DR PRO; PR:Q8BLQ0; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8BLQ0; protein.
DR Bgee; ENSMUSG00000043230; Expressed in spermatid and 50 other tissues.
DR Genevisible; Q8BLQ0; MM.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR029380; FAM124.
DR InterPro; IPR046365; FAM124_dom.
DR PANTHER; PTHR14715; PTHR14715; 1.
DR Pfam; PF15067; FAM124; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..456
FT /note="Protein FAM124B"
FT /id="PRO_0000286385"
FT REGION 262..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 52079 MW; 3A6C94E2F2939DC5 CRC64;
MDEIQEPLAL TVHLLADTGN GLLLQQALDQ LLECICPEVR LFLVSERARP VNYHEKYHPR
RARFPGMSVL LFLQESLGQE RLFRVLDFLR RSPWQGFPTQ HAQGRSCSYL PANQEFYSLH
NQMPVWGMRP VNCGTDILRV TLYCSFDNYE DAIRLYEMLL QRDATVQKSD FCFFVLYATE
GFSLQLSLKQ LPLGMSVDPK ESSVLQFRVQ EIGQLVPLLP NPCVPISSAR WQTQDYDGNK
ILLQVHPKPG VGIKNGEHPF LNGCLRGDTH PQDSSLNSVS TQRTLEPRSR RRSRSRRFKV
HSLELPQPSG SWENSTDPLW RRLGWSTLAD SSASGMQQRR LSIPIEPKMG RNVLREDGFE
KLEAETNVDT GFTIINSEPR RSFPSRFPRD FQSSQPPRCL SGSSLEVTVS PNQGVFKDRL
HPLSLPSQRD FGAKKVISKC SHHLQAQGEE KEEFFI
