AHL5_ARATH
ID AHL5_ARATH Reviewed; 378 AA.
AC Q8GXB3; Q9SH33;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=AT-hook motif nuclear-localized protein 5 {ECO:0000312|EMBL:FAA00276.1};
GN Name=AHL5 {ECO:0000303|PubMed:15604740};
GN OrderedLocusNames=At1g63470 {ECO:0000312|Araport:AT1G63470};
GN ORFNames=F2K11.15 {ECO:0000312|EMBL:AAF19697.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP IDENTIFICATION, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=15604740; DOI=10.1007/s11103-004-3249-5;
RA Fujimoto S., Matsunaga S., Yonemura M., Uchiyama S., Azuma T., Fukui K.;
RT "Identification of a novel plant MAR DNA binding protein localized on
RT chromosomal surfaces.";
RL Plant Mol. Biol. 56:225-239(2004).
RN [6]
RP GENE FAMILY, INTERACTION WITH AHL29, AND DOMAIN PPC.
RX PubMed=24218605; DOI=10.1073/pnas.1219277110;
RA Zhao J., Favero D.S., Peng H., Neff M.M.;
RT "Arabidopsis thaliana AHL family modulates hypocotyl growth redundantly by
RT interacting with each other via the PPC/DUF296 domain.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:E4688-E4697(2013).
CC -!- FUNCTION: Transcription factor that specifically binds AT-rich DNA
CC sequences related to the nuclear matrix attachment regions (MARs).
CC {ECO:0000250|UniProtKB:Q8VYJ2}.
CC -!- SUBUNIT: Interacts with AHL29. {ECO:0000269|PubMed:24218605}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VYJ2}.
CC -!- DOMAIN: The PPC domain mediates interactions between AHL proteins.
CC {ECO:0000269|PubMed:24218605}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF19697.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At1g63470 and At1g63480.; Evidence={ECO:0000305};
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DR EMBL; AC008047; AAF19697.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34103.1; -; Genomic_DNA.
DR EMBL; AK118329; BAC42943.1; -; mRNA.
DR EMBL; BT005545; AAO63965.1; -; mRNA.
DR EMBL; BR000341; FAA00276.1; -; mRNA.
DR RefSeq; NP_176536.2; NM_105026.4.
DR AlphaFoldDB; Q8GXB3; -.
DR SMR; Q8GXB3; -.
DR IntAct; Q8GXB3; 2.
DR STRING; 3702.AT1G63470.1; -.
DR iPTMnet; Q8GXB3; -.
DR PaxDb; Q8GXB3; -.
DR PRIDE; Q8GXB3; -.
DR ProteomicsDB; 244884; -.
DR EnsemblPlants; AT1G63470.1; AT1G63470.1; AT1G63470.
DR GeneID; 842653; -.
DR Gramene; AT1G63470.1; AT1G63470.1; AT1G63470.
DR KEGG; ath:AT1G63470; -.
DR Araport; AT1G63470; -.
DR TAIR; locus:2031321; AT1G63470.
DR eggNOG; ENOG502QUPI; Eukaryota.
DR HOGENOM; CLU_039808_0_2_1; -.
DR InParanoid; Q8GXB3; -.
DR OMA; GSHYYLP; -.
DR OrthoDB; 937709at2759; -.
DR PhylomeDB; Q8GXB3; -.
DR PRO; PR:Q8GXB3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GXB3; baseline and differential.
DR Genevisible; Q8GXB3; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IEA:InterPro.
DR CDD; cd11378; DUF296; 1.
DR InterPro; IPR039605; AHL.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR005175; PPC_dom.
DR PANTHER; PTHR31500; PTHR31500; 1.
DR Pfam; PF03479; PCC; 1.
DR SMART; SM00384; AT_hook; 2.
DR PROSITE; PS51742; PPC; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..378
FT /note="AT-hook motif nuclear-localized protein 5"
FT /id="PRO_0000432023"
FT DOMAIN 171..314
FT /note="PPC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01078"
FT DNA_BIND 105..117
FT /note="A.T hook 1"
FT /evidence="ECO:0000255"
FT DNA_BIND 147..159
FT /note="A.T hook 2"
FT /evidence="ECO:0000255"
FT REGION 30..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 105..113
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000305"
FT COMPBIAS 34..48
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 39644 MW; 20FFF92CAB95D70D CRC64;
MDGREAMAFP GSHSQFYLQR GVFTNLTPSQ VASGLHAPPP PPGMRPMSNP NIHHPQASNP
GPPFSMAEHR HSDFGHSIHM GMASPAAVQP TLQLPPPPSE QPMVKKKRGR PRKYVPDGQV
SLGLSPMPCV SKKSKDSSSM SDPNAPKRAR GRPPGTGRKQ RLANLGEWMN TSAGLAFAPH
VISVGSGEDI VSKVLSFSQK RPRALCIMSG TGTVSSVTLR EPASTTPSLT FEGRFEILSL
GGSYLVNEEG GSKSRTGGLS VSLSGPEGHV IGGGIGMLIA ASLVQVVACS FVYGASAKSN
NNNNKTIKQE IKPKQEPTNS EMETTPGSAP EAAASTGQHT PQNFPAQGMS GWPVSGSGSG
RSLDSSRNPL TDIDLTRG
