ID   F126B_PONAB             Reviewed;         530 AA.
AC   Q5R977;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Protein FAM126B;
GN   Name=FAM126B;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of a complex required to localize
CC       phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q8IXS8}.
CC   -!- SUBUNIT: Component of a phosphatidylinositol 4-kinase (PI4K) complex,
CC       composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and
CC       FAM126 (FAM126A or FAM126B). {ECO:0000250|UniProtKB:Q8IXS8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9BYI3}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9BYI3}.
CC   -!- SIMILARITY: Belongs to the FAM126 family. {ECO:0000305}.
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DR   EMBL; CR859515; CAH91683.1; -; mRNA.
DR   RefSeq; NP_001125986.1; NM_001132514.1.
DR   AlphaFoldDB; Q5R977; -.
DR   SMR; Q5R977; -.
DR   STRING; 9601.ENSPPYP00000023730; -.
DR   Ensembl; ENSPPYT00000034027; ENSPPYP00000023730; ENSPPYG00000029836.
DR   GeneID; 100172925; -.
DR   KEGG; pon:100172925; -.
DR   CTD; 285172; -.
DR   eggNOG; KOG4688; Eukaryota.
DR   GeneTree; ENSGT00390000011295; -.
DR   InParanoid; Q5R977; -.
DR   OrthoDB; 673408at2759; -.
DR   Proteomes; UP000001595; Chromosome 2B.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018619; Hyccin.
DR   PANTHER; PTHR31220; PTHR31220; 1.
DR   Pfam; PF09790; Hyccin; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Membrane; Phosphoprotein; Reference proteome.
FT   CHAIN           1..530
FT                   /note="Protein FAM126B"
FT                   /id="PRO_0000278096"
FT   REGION          328..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          498..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..377
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..394
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        395..410
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        512..530
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         30
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IXS8"
FT   MOD_RES         306
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IXS8"
FT   MOD_RES         321
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IXS8"
FT   MOD_RES         341
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8C729"
FT   MOD_RES         430
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IXS8"
FT   MOD_RES         442
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IXS8"
FT   MOD_RES         444
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IXS8"
FT   MOD_RES         491
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IXS8"
SQ   SEQUENCE   530 AA;  58634 MW;  43B492A7B7E818B0 CRC64;
     MLGTDRCVVE EWLSEFKALP DTQITSYAAT LHRKKTLVPA LYKVIQDSNN ELLEPVCHQL
     FELYRSSEVR LKRFTLQFLP ELMWVYLRLT VSRDRQSNGC IEALLLGIYN LEIADKDGNN
     KVLSFTIPSL SKPSIYHEPS TIGSMALTEG ALCQHDLIRV VYSDLHPQRE TFTAQNRFEV
     LSFLMLCYNS AIVYMPASSY QSLCRMGSRV CVSGFPRQHE KHWKELCGRI VLDPEFMVQL
     LTGVYYAMYN GQWDLGQEVL DDIIYRAQLE LFSQPLLVAN AMKNSLPFDA PDSTQEGQKV
     LKVEVTPTVP RISRTAITTA SIRRHRWRRE GAEGVNGGEE SVNLNDADEG FSSGASLSSQ
     PIGTKPSSSS QRGSLRKVAT GRSAKDKETA SAIKSSESPR DSVVRKQYVQ QPTDLSVDSV
     ELTPMKKHLS LPAGQVVPKT NSLSLIRTAS ASSSKSFDYV NGSQASTSIG VGTEGGTNLA
     ANNANRYSTV SLQEDRLGQA GEGKELLSPG APLTKQSRSP SFNMQLISQV