ID   F12_CAMPM               Reviewed;         635 AA.
AC   Q8V2X0;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   29-SEP-2021, entry version 50.
DE   RecName: Full=Protein F12 homolog;
GN   OrderedLocusNames=CMLV047;
OS   Camelpox virus (strain M-96).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=203173;
OH   NCBI_TaxID=9836; Camelus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12033760; DOI=10.1006/viro.2001.1343;
RA   Afonso C.L., Tulman E.R., Lu Z., Zsak L., Sandybaev N.T., Kerembekova U.Z.,
RA   Zaitsev V.L., Kutish G.F., Rock D.L.;
RT   "The genome of camelpox virus.";
RL   Virology 295:1-9(2002).
CC   -!- FUNCTION: Late protein that plays a role in intracellular enveloped
CC       virus (IEV) transport to the cell surface on microtubules. When absent,
CC       viral morphogenesis halts after the formation of IEV particles, and
CC       these are not transported to the cell periphery. Important for plaque
CC       formation, extracellular envelope virus (EEV) production and virulence
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}. Host endosome
CC       {ECO:0000250}. Note=Associates with the membrane of IEV particles, but
CC       not intracellular mature virus (IMV), cell-associated enveloped virus
CC       (CEV) or EEV. Colocalizes with microtubules (By similarity).
CC       {ECO:0000250}.
CC   -!- PTM: Not glycosylated or contains very little carbohydrate.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae F12 protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF438165; AAL73754.1; -; Genomic_DNA.
DR   RefSeq; NP_570437.1; NC_003391.1.
DR   GeneID; 932580; -.
DR   KEGG; vg:932580; -.
DR   Proteomes; UP000152221; Genome.
DR   GO; GO:0044174; C:host cell endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR005005; Poxvirus_F12L.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   Pfam; PF03337; Pox_F12L; 1.
DR   PIRSF; PIRSF015793; VAC_EEV; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Host endosome; Late protein; Membrane; Virion; Virulence.
FT   CHAIN           1..635
FT                   /note="Protein F12 homolog"
FT                   /id="PRO_0000343641"
SQ   SEQUENCE   635 AA;  73348 MW;  CCD5DA1793F4AFF6 CRC64;
     MLNRVQILMK TANNYETIEI LRNYLRLYII LARNEEGHGI LIYDDNIDSI MSMMNITRLE
     VIGLTTHCTK LRSSPPIPMS RLFMDEIDHE SYYSPKTSDY PLIDIIRNRS HEQGDIALAL
     ERYGIDNTDS ISEINEWLSS KGLACYRFVK FNDYRKQMYR KFSKCTIVDS MIIGHIGHHY
     IWIKNLETYT RPEIDVLPFD IKYISRDELW VRISSSLDQT HIKTIAVSVY GAITDNGPMP
     YMISTYPGNT FVNFNSVKDL ILNFLDWIKD IMTSTRTIIL VGYMSNLFDI PLLTVYWPNN
     CGWKIYNNIL ISSDGARVIW MDAYKFSCGL SLQDYCYHWG SKPESRPFDL IKKSDAKRNI
     KSWVKESMTS LKSLYEAFET QSGALEVLMS PCRMFSFSRI EDMFLTSVIN RVSENTGMGM
     YYPTNDISSL FIESSICLDY IIVNNQESNK YRIKSVLDII SSKQYPAGRP NYVKNGTKGK
     LYIALCKVTV PTNDHIPVVY HDDDNTTTFI TVLTSVDIET ATRAGYSIVE LGALQWDDNI
     PELKDCLLDS IKMIYDLNAA TTNNLLEQLI ENINFNNSSI ILLFYTFAIS YCRAFIYSII
     ETIDPVYISQ FSYKELYISS SYKDINEVMS QMVKL