ID   F12_FOWPN               Reviewed;         630 AA.
AC   P36317;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   23-FEB-2022, entry version 81.
DE   RecName: Full=Virion release protein;
DE   AltName: Full=Protein F12 homolog;
GN   OrderedLocusNames=FPV109;
OS   Fowlpox virus (strain NVSL) (FPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX   NCBI_TaxID=928301;
OH   NCBI_TaxID=7742; Vertebrata.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8380837; DOI=10.1099/0022-1317-74-1-55;
RA   Ogawa R., Calvert J.G., Yanagida N., Nazerian K.;
RT   "Insertional inactivation of a fowlpox virus homologue of the vaccinia
RT   virus F12L gene inhibits the release of enveloped virions.";
RL   J. Gen. Virol. 74:55-64(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10729156; DOI=10.1128/jvi.74.8.3815-3831.2000;
RA   Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT   "The genome of fowlpox virus.";
RL   J. Virol. 74:3815-3831(2000).
CC   -!- FUNCTION: Late protein that plays a role in intracellular enveloped
CC       virus (IEV) transport to the cell surface on microtubules. When absent,
CC       viral morphogenesis halts after the formation of IEV particles, and
CC       these are not transported to the cell periphery. Important for plaque
CC       formation, extracellular envelope virus (EEV) production and virulence
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}. Host endosome
CC       {ECO:0000250}. Note=Associates with the membrane of IEV particles, but
CC       not intracellular mature virus (IMV), cell-associated enveloped virus
CC       (CEV) or EEV. Colocalizes with microtubules (By similarity).
CC       {ECO:0000250}.
CC   -!- PTM: Not glycosylated or contains very little carbohydrate.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae F12 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M88588; AAA47187.1; -; Genomic_DNA.
DR   EMBL; M88587; AAA43820.1; -; Genomic_DNA.
DR   EMBL; AF198100; AAF44453.1; -; Genomic_DNA.
DR   PIR; JQ1894; JQ1894.
DR   RefSeq; NP_039072.1; NC_002188.1.
DR   GeneID; 1486657; -.
DR   KEGG; vg:1486657; -.
DR   Proteomes; UP000008597; Genome.
DR   GO; GO:0044174; C:host cell endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR005005; Poxvirus_F12L.
DR   InterPro; IPR008917; TF_DNA-bd_sf.
DR   Pfam; PF03337; Pox_F12L; 1.
DR   PIRSF; PIRSF015793; VAC_EEV; 1.
DR   SUPFAM; SSF47454; SSF47454; 1.
PE   3: Inferred from homology;
KW   Host endosome; Late protein; Membrane; Reference proteome; Virion;
KW   Virulence.
FT   CHAIN           1..630
FT                   /note="Virion release protein"
FT                   /id="PRO_0000099505"
SQ   SEQUENCE   630 AA;  74099 MW;  CD8E1F102032020F CRC64;
     MALIEQLQSS EQSILSPFRY YGFKDFHNVI FTTIDDETLI VITVNNVPLV TRLITFEKIT
     FFRSFNSTCI ITSNNNSDID TDTYFIPNSL SLLDILKKRA YDVELRDLSF AIMSEMNNDE
     LRNSDIVSLN KWLHKHNLLD YKLVLISDID RRYKLYNKKN TIIDVISVNG RNYNIWVKDV
     IEYYSPEYLR WSIDIKRATE SNNWLPYSQS INPLNENIYA FEFIATLERS NERLNIGAIF
     LYPDIIITGR NNEDIIEKFL DQLEEVIYKK NSDSIVLTGY HLTFLENTIL ERYISKYKDW
     IFTCNRLVHC KTGTEVFLFD AAIFFPSSNK KGYVKHWTGK KLNFKNFFQK DSQLEKYINN
     NSVAERIYYL QSSLHKHISC LIEIFELNGF DFNFSGLLDI LIFSIRVKNN NGNYYYPKHS
     SAVNLMLSSI YTDYYAIDDI DKDSKKLVFN SIFPLIMEGY YPEGKPYYTK TPKEGYLSIC
     LCDVEISNDI KNPILYCKEN KSARKFTGVF TSVDIDTAVK LRGYKIKILE CIEWPNKIKL
     FDNICYLNKL FIEHQDYTHD EKSLQGYLFS YLLKGNVTED VLAMKSCRNN LSIISFIISY
     CRNYTYKLLE CPVYESSNIV KCKYNQVIYK