AHL6_ARATH
ID AHL6_ARATH Reviewed; 404 AA.
AC Q9LVB0;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=AT-hook motif nuclear-localized protein 6 {ECO:0000312|EMBL:FAA00277.1};
GN Name=AHL6 {ECO:0000303|PubMed:15604740};
GN OrderedLocusNames=At5g62260 {ECO:0000312|Araport:AT5G62260};
GN ORFNames=MMI9.9 {ECO:0000312|EMBL:BAA97190.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP IDENTIFICATION, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=15604740; DOI=10.1007/s11103-004-3249-5;
RA Fujimoto S., Matsunaga S., Yonemura M., Uchiyama S., Azuma T., Fukui K.;
RT "Identification of a novel plant MAR DNA binding protein localized on
RT chromosomal surfaces.";
RL Plant Mol. Biol. 56:225-239(2004).
RN [6]
RP GENE FAMILY, AND DOMAIN PPC.
RX PubMed=24218605; DOI=10.1073/pnas.1219277110;
RA Zhao J., Favero D.S., Peng H., Neff M.M.;
RT "Arabidopsis thaliana AHL family modulates hypocotyl growth redundantly by
RT interacting with each other via the PPC/DUF296 domain.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:E4688-E4697(2013).
CC -!- FUNCTION: Transcription factor that specifically binds AT-rich DNA
CC sequences related to the nuclear matrix attachment regions (MARs).
CC {ECO:0000250|UniProtKB:Q8VYJ2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VYJ2}.
CC -!- DOMAIN: The PPC domain mediates interactions between AHL proteins.
CC {ECO:0000269|PubMed:24218605}.
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DR EMBL; AB019235; BAA97190.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97587.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM70608.1; -; Genomic_DNA.
DR EMBL; AK118328; BAC42942.1; -; mRNA.
DR EMBL; BT005681; AAO64101.1; -; mRNA.
DR EMBL; BR000342; FAA00277.1; -; mRNA.
DR RefSeq; NP_001332202.1; NM_001345545.1.
DR RefSeq; NP_201032.2; NM_125620.3.
DR AlphaFoldDB; Q9LVB0; -.
DR SMR; Q9LVB0; -.
DR IntAct; Q9LVB0; 6.
DR STRING; 3702.AT5G62260.1; -.
DR iPTMnet; Q9LVB0; -.
DR PaxDb; Q9LVB0; -.
DR PRIDE; Q9LVB0; -.
DR ProteomicsDB; 244781; -.
DR EnsemblPlants; AT5G62260.1; AT5G62260.1; AT5G62260.
DR EnsemblPlants; AT5G62260.3; AT5G62260.3; AT5G62260.
DR GeneID; 836347; -.
DR Gramene; AT5G62260.1; AT5G62260.1; AT5G62260.
DR Gramene; AT5G62260.3; AT5G62260.3; AT5G62260.
DR KEGG; ath:AT5G62260; -.
DR Araport; AT5G62260; -.
DR TAIR; locus:2167988; AT5G62260.
DR eggNOG; ENOG502QTAR; Eukaryota.
DR HOGENOM; CLU_039808_0_0_1; -.
DR InParanoid; Q9LVB0; -.
DR OrthoDB; 1053982at2759; -.
DR PhylomeDB; Q9LVB0; -.
DR PRO; PR:Q9LVB0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LVB0; baseline and differential.
DR Genevisible; Q9LVB0; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IEA:InterPro.
DR CDD; cd11378; DUF296; 1.
DR InterPro; IPR039605; AHL.
DR InterPro; IPR005175; PPC_dom.
DR PANTHER; PTHR31500; PTHR31500; 1.
DR Pfam; PF03479; PCC; 1.
DR PROSITE; PS51742; PPC; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..404
FT /note="AT-hook motif nuclear-localized protein 6"
FT /id="PRO_0000432024"
FT DOMAIN 157..299
FT /note="PPC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01078"
FT DNA_BIND 76..88
FT /note="A.T hook"
FT /evidence="ECO:0000255"
FT REGION 40..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 76..84
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000305"
FT COMPBIAS 42..57
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 42804 MW; 7FA976AEE0677B2A CRC64;
MEEKGEISPS GVVTVKGDEA LVPRTEFQQN PSFLQFVSPT TVVTPLPPPP APSSAPVPTT
VTPGSATAST GSDPTKKKRG RPRKYAPDGS LNPRFLRPTL SPTPISSSIP LSGDYQWKRG
KAQQQHQPLE FVKKSHKFEY GSPAPTPPLP GLSCYVGANF TTHQFTVNGG EDVTMKVMPY
SQQGSRAICI LSATGSISNV TLGQPTNAGG TLTYEGRFEI LSLSGSFMPT ENGGTKGRAG
GMSISLAGPN GNIFGGGLAG MLIAAGPVQV VMGSFIVMHQ AEQNQKKKPR VMEAFAPPQP
QAPPQLQQQQ PPTFTITTVN STSPSVNTVE EQKPQAYGGG IVRPMAQMPS SFQNDNSTMN
NFTPAYHGYG NMNTGTTHKE EHEDEDGGDD DDDSGDTRSQ SHSG
