F131A_HUMAN
ID F131A_HUMAN Reviewed; 366 AA.
AC Q6UXB0; D3DNT6; G5E9B1; Q8TA84;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2019, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein FAM131A;
GN Name=FAM131A; Synonyms=C3orf40; ORFNames=UNQ715/PRO1378;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 74-366 (ISOFORM 3).
RC TISSUE=Duodenum, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] ASN-291.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=3;
CC IsoId=Q6UXB0-3; Sequence=Displayed;
CC Name=1;
CC IsoId=Q6UXB0-1; Sequence=VSP_059988;
CC Name=2;
CC IsoId=Q6UXB0-2; Sequence=VSP_059989;
CC -!- SIMILARITY: Belongs to the FAM131 family. {ECO:0000305}.
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DR EMBL; AY358435; AAQ88801.1; -; mRNA.
DR EMBL; AC078797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW78252.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78254.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78255.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78256.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78253.1; -; Genomic_DNA.
DR EMBL; BC026221; AAH26221.1; -; mRNA.
DR EMBL; BC037299; AAH37299.1; -; mRNA.
DR CCDS; CCDS3262.2; -. [Q6UXB0-3]
DR CCDS; CCDS54689.1; -. [Q6UXB0-2]
DR RefSeq; NP_001164564.1; NM_001171093.1. [Q6UXB0-2]
DR RefSeq; NP_653236.3; NM_144635.4. [Q6UXB0-3]
DR RefSeq; XP_005247170.1; XM_005247113.2.
DR RefSeq; XP_005247171.1; XM_005247114.3. [Q6UXB0-2]
DR RefSeq; XP_011510715.1; XM_011512413.2.
DR AlphaFoldDB; Q6UXB0; -.
DR BioGRID; 126280; 5.
DR IntAct; Q6UXB0; 2.
DR STRING; 9606.ENSP00000373360; -.
DR iPTMnet; Q6UXB0; -.
DR BioMuta; FAM131A; -.
DR DMDM; 74738196; -.
DR MassIVE; Q6UXB0; -.
DR MaxQB; Q6UXB0; -.
DR PaxDb; Q6UXB0; -.
DR PeptideAtlas; Q6UXB0; -.
DR PRIDE; Q6UXB0; -.
DR ProteomicsDB; 33886; -.
DR ProteomicsDB; 67580; -. [Q6UXB0-1]
DR ProteomicsDB; 67581; -. [Q6UXB0-2]
DR Antibodypedia; 52588; 52 antibodies from 12 providers.
DR DNASU; 131408; -.
DR Ensembl; ENST00000310585.4; ENSP00000310135.4; ENSG00000175182.15. [Q6UXB0-1]
DR Ensembl; ENST00000340957.9; ENSP00000340974.5; ENSG00000175182.15. [Q6UXB0-2]
DR Ensembl; ENST00000383847.7; ENSP00000373360.2; ENSG00000175182.15. [Q6UXB0-3]
DR Ensembl; ENST00000450976.5; ENSP00000388551.1; ENSG00000175182.15. [Q6UXB0-2]
DR Ensembl; ENST00000453072.5; ENSP00000390588.1; ENSG00000175182.15. [Q6UXB0-2]
DR GeneID; 131408; -.
DR KEGG; hsa:131408; -.
DR MANE-Select; ENST00000383847.7; ENSP00000373360.2; NM_144635.5; NP_653236.3.
DR UCSC; uc003foc.4; human. [Q6UXB0-3]
DR CTD; 131408; -.
DR DisGeNET; 131408; -.
DR GeneCards; FAM131A; -.
DR HGNC; HGNC:28308; FAM131A.
DR HPA; ENSG00000175182; Low tissue specificity.
DR neXtProt; NX_Q6UXB0; -.
DR OpenTargets; ENSG00000175182; -.
DR PharmGKB; PA162386054; -.
DR VEuPathDB; HostDB:ENSG00000175182; -.
DR eggNOG; ENOG502QR3P; Eukaryota.
DR GeneTree; ENSGT00950000183106; -.
DR HOGENOM; CLU_074265_0_0_1; -.
DR InParanoid; Q6UXB0; -.
DR OMA; FMPSTES; -.
DR OrthoDB; 1284211at2759; -.
DR PhylomeDB; Q6UXB0; -.
DR TreeFam; TF331537; -.
DR PathwayCommons; Q6UXB0; -.
DR SignaLink; Q6UXB0; -.
DR BioGRID-ORCS; 131408; 7 hits in 1076 CRISPR screens.
DR ChiTaRS; FAM131A; human.
DR GenomeRNAi; 131408; -.
DR Pharos; Q6UXB0; Tdark.
DR PRO; PR:Q6UXB0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6UXB0; protein.
DR Bgee; ENSG00000175182; Expressed in prefrontal cortex and 200 other tissues.
DR ExpressionAtlas; Q6UXB0; baseline and differential.
DR Genevisible; Q6UXB0; HS.
DR InterPro; IPR026782; FAM131.
DR PANTHER; PTHR15736; PTHR15736; 1.
DR Pfam; PF15010; FAM131; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..366
FT /note="Protein FAM131A"
FT /id="PRO_0000243932"
FT REGION 342..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..108
FT /note="MPMISVLGKMFLWQREGPGGRWTCQTSRRVSSDPAWAVEWIELPRGLSLSSL
FT GSARTLRGWSRSSRPSSVDSQDLPEVNVGDTVAMLPKSRRALTIQEIAALARSSLH ->
FT MFLATLSFLLPFAHPFGTVSCEYMLGSPLSSLAQVNLSPFSHPKVHMDPNYCHPSTSLH
FT LCSLAWSFTRLLHPPLSP (in isoform 1)"
FT /id="VSP_059988"
FT VAR_SEQ 1..85
FT /note="Missing (in isoform 2)"
FT /id="VSP_059989"
FT VARIANT 291
FT /note="S -> N (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036118"
SQ SEQUENCE 366 AA; 39503 MW; 2A21A6FE9FADC40E CRC64;
MPMISVLGKM FLWQREGPGG RWTCQTSRRV SSDPAWAVEW IELPRGLSLS SLGSARTLRG
WSRSSRPSSV DSQDLPEVNV GDTVAMLPKS RRALTIQEIA ALARSSLHGI SQVVKDHVTK
PTAMAQGRVA HLIEWKGWSK PSDSPAALES AFSSYSDLSE GEQEARFAAG VAEQFAIAEA
KLRAWSSVDG EDSTDDSYDE DFAGGMDTDM AGQLPLGPHL QDLFTGHRFS RPVRQGSVEP
ESDCSQTVSP DTLCSSLCSL EDGLLGSPAR LASQLLGDEL LLAKLPPSRE SAFRSLGPLE
AQDSLYNSPL TESCLSPAEE EPAPCKDCQP LCPPLTGSWE RQRQASDLAS SGVVSLDEDE
AEPEEQ
