F131B_HUMAN
ID F131B_HUMAN Reviewed; 332 AA.
AC Q86XD5; A4D2H6; A6NDW3; A8K605; B8ZZN2; D3DXE3; J3KQX2; Q7L0D6; Q86T97;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 3.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein FAM131B;
GN Name=FAM131B; Synonyms=KIAA0773;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Spinal cord;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT THR-307.
RC TISSUE=Brain, and Hypothalamus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP MYRISTOYLATION AT GLY-2 (ISOFORM 2).
RX PubMed=20213681; DOI=10.1002/pmic.200900783;
RA Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,
RA Tsunasawa S., Utsumi T.;
RT "Strategy for comprehensive identification of human N-myristoylated
RT proteins using an insect cell-free protein synthesis system.";
RL Proteomics 10:1780-1793(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- INTERACTION:
CC Q86XD5; Q9BSI4: TINF2; NbExp=2; IntAct=EBI-11308812, EBI-717399;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q86XD5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86XD5-2; Sequence=VSP_041633;
CC Name=3;
CC IsoId=Q86XD5-3; Sequence=VSP_046798;
CC -!- SIMILARITY: Belongs to the FAM131 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS07501.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK291470; BAF84159.1; -; mRNA.
DR EMBL; AL832579; CAD89938.1; -; mRNA.
DR EMBL; AC093673; AAS07501.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH236959; EAL23787.1; -; Genomic_DNA.
DR EMBL; CH471198; EAW51853.1; -; Genomic_DNA.
DR EMBL; CH471198; EAW51854.1; -; Genomic_DNA.
DR EMBL; BC045611; AAH45611.2; -; mRNA.
DR EMBL; BC050543; AAH50543.2; -; mRNA.
DR CCDS; CCDS47734.1; -. [Q86XD5-3]
DR CCDS; CCDS5882.1; -. [Q86XD5-1]
DR RefSeq; NP_001026860.2; NM_001031690.2. [Q86XD5-3]
DR RefSeq; NP_001265226.1; NM_001278297.1.
DR RefSeq; NP_055505.3; NM_014690.4. [Q86XD5-1]
DR RefSeq; XP_005250130.1; XM_005250073.3.
DR RefSeq; XP_006716249.1; XM_006716186.2.
DR AlphaFoldDB; Q86XD5; -.
DR BioGRID; 115064; 48.
DR IntAct; Q86XD5; 31.
DR STRING; 9606.ENSP00000410603; -.
DR iPTMnet; Q86XD5; -.
DR PhosphoSitePlus; Q86XD5; -.
DR SwissPalm; Q86XD5; -.
DR BioMuta; FAM131B; -.
DR EPD; Q86XD5; -.
DR jPOST; Q86XD5; -.
DR MassIVE; Q86XD5; -.
DR MaxQB; Q86XD5; -.
DR PaxDb; Q86XD5; -.
DR PeptideAtlas; Q86XD5; -.
DR PRIDE; Q86XD5; -.
DR ProteomicsDB; 70264; -. [Q86XD5-1]
DR ProteomicsDB; 70265; -. [Q86XD5-2]
DR Antibodypedia; 18478; 48 antibodies from 11 providers.
DR DNASU; 9715; -.
DR Ensembl; ENST00000409222.7; ENSP00000387147.3; ENSG00000159784.18. [Q86XD5-1]
DR Ensembl; ENST00000409346.5; ENSP00000386984.1; ENSG00000159784.18. [Q86XD5-1]
DR Ensembl; ENST00000409408.5; ENSP00000387017.1; ENSG00000159784.18. [Q86XD5-1]
DR Ensembl; ENST00000409578.5; ENSP00000386568.1; ENSG00000159784.18. [Q86XD5-2]
DR Ensembl; ENST00000443739.7; ENSP00000410603.2; ENSG00000159784.18. [Q86XD5-3]
DR GeneID; 9715; -.
DR KEGG; hsa:9715; -.
DR MANE-Select; ENST00000443739.7; ENSP00000410603.2; NM_001031690.3; NP_001026860.2. [Q86XD5-3]
DR UCSC; uc003wct.4; human. [Q86XD5-1]
DR CTD; 9715; -.
DR DisGeNET; 9715; -.
DR GeneCards; FAM131B; -.
DR HGNC; HGNC:22202; FAM131B.
DR HPA; ENSG00000159784; Tissue enriched (brain).
DR MIM; 619282; gene.
DR neXtProt; NX_Q86XD5; -.
DR NIAGADS; ENSG00000159784; -.
DR OpenTargets; ENSG00000159784; -.
DR PharmGKB; PA162386065; -.
DR VEuPathDB; HostDB:ENSG00000159784; -.
DR eggNOG; ENOG502QXPE; Eukaryota.
DR GeneTree; ENSGT00950000183106; -.
DR HOGENOM; CLU_047357_1_0_1; -.
DR InParanoid; Q86XD5; -.
DR OMA; NQENPAG; -.
DR OrthoDB; 864510at2759; -.
DR PhylomeDB; Q86XD5; -.
DR TreeFam; TF331537; -.
DR PathwayCommons; Q86XD5; -.
DR Reactome; R-HSA-6802952; Signaling by BRAF and RAF1 fusions.
DR SignaLink; Q86XD5; -.
DR BioGRID-ORCS; 9715; 8 hits in 1069 CRISPR screens.
DR ChiTaRS; FAM131B; human.
DR GenomeRNAi; 9715; -.
DR Pharos; Q86XD5; Tdark.
DR PRO; PR:Q86XD5; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q86XD5; protein.
DR Bgee; ENSG00000159784; Expressed in cortical plate and 144 other tissues.
DR ExpressionAtlas; Q86XD5; baseline and differential.
DR Genevisible; Q86XD5; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR026782; FAM131.
DR PANTHER; PTHR15736; PTHR15736; 1.
DR Pfam; PF15010; FAM131; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Lipoprotein; Myristate; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..332
FT /note="Protein FAM131B"
FT /id="PRO_0000253032"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 47
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3TY60"
FT MOD_RES 114
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3TY60"
FT MOD_RES 117
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 295
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3TY60"
FT MOD_RES 297
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3TY60"
FT MOD_RES 313
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3TY60"
FT MOD_RES 316
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q3TY60"
FT MOD_RES 317
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3TY60"
FT MOD_RES 318
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3TY60"
FT MOD_RES 322
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3TY60"
FT VAR_SEQ 1..30
FT /note="MDSTSSLHGSSLHRPSTEQTRTDFSWDGIN -> MGCIGSRTVGNEVIAVDW
FT KGLKDVDQINMDSTSSLHGSSLHRPSTE (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_041633"
FT VAR_SEQ 1
FT /note="M -> MGCIGSRTVGNEVIAVDWKGLKDVDQINM (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_046798"
FT VARIANT 307
FT /note="A -> T (in dbSNP:rs17854363)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_053920"
FT CONFLICT 47
FT /note="S -> F (in Ref. 2; CAD89938)"
FT /evidence="ECO:0000305"
FT CONFLICT 141
FT /note="M -> T (in Ref. 2; CAD89938)"
FT /evidence="ECO:0000305"
FT CONFLICT 285
FT /note="E -> G (in Ref. 6; AAH45611)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="R -> Q (in Ref. 6; AAH45611)"
FT /evidence="ECO:0000305"
FT INIT_MET Q86XD5-2:1
FT /note="Removed"
FT /evidence="ECO:0000305"
FT LIPID Q86XD5-2:2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000269|PubMed:20213681"
SQ SEQUENCE 332 AA; 35769 MW; 35FE42189855034F CRC64;
MDSTSSLHGS SLHRPSTEQT RTDFSWDGIN LSMEDTTSIL PKLKRNSNAY GIGALAKSSF
SGISRSMKDH VTKPTAMGQG RVAHMIEWQG WGKTPAVQPQ HSHESVRRDT DAYSDLSDGE
KEARFLAGVM EQFAISEATL MAWSSMDGED MSVNSTQEPL GCNYSDNYQE LMDSQDALAQ
APMDGWPHSY VSQGMYCLGS SDAWEASDQS LIASPATGSY LGPAFDDSQP SLHEMGPSQP
ASGYSALEPP PLLGGDTDWA PGVGAVDLAR GPAEEEKRPL APEEEEDAGC RDLESLSPRE
DPEMSTALSR KVSDVTSSGV QSFDEEEGEA NN
