F131B_MOUSE
ID F131B_MOUSE Reviewed; 332 AA.
AC Q3TY60; Q3TQE4; Q9D390;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Protein FAM131B;
GN Name=Fam131b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J;
RC TISSUE=Corpus striatum, Medulla oblongata, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117 AND SER-322, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain cortex;
RX PubMed=17114649; DOI=10.1074/mcp.m600046-mcp200;
RA Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,
RA Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B.,
RA Panse C., Schlapbach R., Mansuy I.M.;
RT "Qualitative and quantitative analyses of protein phosphorylation in naive
RT and stimulated mouse synaptosomal preparations.";
RL Mol. Cell. Proteomics 6:283-293(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47; SER-114; SER-117;
RP SER-295; SER-297; SER-313; THR-316; SER-317; SER-318 AND SER-322, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3TY60-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TY60-2; Sequence=VSP_020994, VSP_020995;
CC -!- SIMILARITY: Belongs to the FAM131 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB31120.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC33149.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK047763; BAC33149.1; ALT_INIT; mRNA.
DR EMBL; AK158869; BAE34703.1; -; mRNA.
DR EMBL; AK163654; BAE37440.1; -; mRNA.
DR EMBL; AK018206; BAB31120.1; ALT_INIT; mRNA.
DR CCDS; CCDS51758.1; -. [Q3TY60-2]
DR CCDS; CCDS71759.1; -. [Q3TY60-1]
DR RefSeq; NP_001106798.1; NM_001113327.2. [Q3TY60-2]
DR RefSeq; NP_001273513.1; NM_001286584.1. [Q3TY60-1]
DR RefSeq; NP_083804.3; NM_029528.5.
DR AlphaFoldDB; Q3TY60; -.
DR IntAct; Q3TY60; 1.
DR MINT; Q3TY60; -.
DR STRING; 10090.ENSMUSP00000116779; -.
DR iPTMnet; Q3TY60; -.
DR PhosphoSitePlus; Q3TY60; -.
DR SwissPalm; Q3TY60; -.
DR PaxDb; Q3TY60; -.
DR PRIDE; Q3TY60; -.
DR ProteomicsDB; 275711; -. [Q3TY60-1]
DR ProteomicsDB; 275712; -. [Q3TY60-2]
DR Antibodypedia; 18478; 48 antibodies from 11 providers.
DR DNASU; 76156; -.
DR Ensembl; ENSMUST00000031891; ENSMUSP00000031891; ENSMUSG00000029861. [Q3TY60-2]
DR Ensembl; ENSMUST00000095974; ENSMUSP00000093670; ENSMUSG00000029861. [Q3TY60-1]
DR GeneID; 76156; -.
DR KEGG; mmu:76156; -.
DR UCSC; uc009bqv.3; mouse. [Q3TY60-2]
DR UCSC; uc033ipo.1; mouse. [Q3TY60-1]
DR CTD; 9715; -.
DR MGI; MGI:1923406; Fam131b.
DR VEuPathDB; HostDB:ENSMUSG00000029861; -.
DR eggNOG; ENOG502QXPE; Eukaryota.
DR GeneTree; ENSGT00950000183106; -.
DR HOGENOM; CLU_047357_1_0_1; -.
DR InParanoid; Q3TY60; -.
DR OrthoDB; 864510at2759; -.
DR PhylomeDB; Q3TY60; -.
DR BioGRID-ORCS; 76156; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q3TY60; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q3TY60; protein.
DR Bgee; ENSMUSG00000029861; Expressed in cerebellum lobe and 107 other tissues.
DR ExpressionAtlas; Q3TY60; baseline and differential.
DR Genevisible; Q3TY60; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR026782; FAM131.
DR PANTHER; PTHR15736; PTHR15736; 1.
DR Pfam; PF15010; FAM131; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..332
FT /note="Protein FAM131B"
FT /id="PRO_0000253033"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 47
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 114
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 117
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:16452087,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 295
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 297
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 313
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 316
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 317
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 318
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 322
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:16452087,
FT ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1
FT /note="M -> MGCIGSRTVGNEVIAVDWKGLKDVDQINM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020994"
FT VAR_SEQ 19..30
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020995"
SQ SEQUENCE 332 AA; 35958 MW; 4DD80BD549500783 CRC64;
MDSTSSLHGS SLHRPSTEQT RTDFSWDGIN LSMEDTTSIL PKLKRNSNAY GIGALAKSSF
SGISRSMKDH VTKPTAMGQG RVAHMIEWQG WGKAPTIQPQ HSHEAVRRDT DAYSDLSDGE
KEARFLAGVM EQFAISEATL MAWSSMDGED MSVNSTQEPL DCNYSDNYQE LMESQDALAQ
APMDGWPHSY VSQGMYCLGS SDAWEASDQS LIASPATGSY LGPAFDDSQP SLHDMGPSQP
ASGYSAQEPP PLLGVDTDWA SEVGGVELAR GPVEEEKRPL APEEEEDAGC RDLESLSPRE
DPEMSTALSR KVSDVTSSGV QSFDEEEGDA NN
