F133A_HUMAN
ID F133A_HUMAN Reviewed; 248 AA.
AC Q8N9E0;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein FAM133A;
GN Name=FAM133A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N9E0; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-10268158, EBI-2803601;
CC Q8N9E0; Q8N7W2-2: BEND7; NbExp=3; IntAct=EBI-10268158, EBI-10181188;
CC Q8N9E0; Q9UK58: CCNL1; NbExp=3; IntAct=EBI-10268158, EBI-2836773;
CC Q8N9E0; Q8NHQ1: CEP70; NbExp=6; IntAct=EBI-10268158, EBI-739624;
CC Q8N9E0; P68400: CSNK2A1; NbExp=5; IntAct=EBI-10268158, EBI-347804;
CC Q8N9E0; Q5HYN5: CT45A1; NbExp=3; IntAct=EBI-10268158, EBI-12051833;
CC Q8N9E0; U3KQK0: H2BC15; NbExp=5; IntAct=EBI-10268158, EBI-12142839;
CC Q8N9E0; O75367: MACROH2A1; NbExp=3; IntAct=EBI-10268158, EBI-2868511;
CC Q8N9E0; Q9P0M6: MACROH2A2; NbExp=3; IntAct=EBI-10268158, EBI-3922608;
CC Q8N9E0; Q9BU76: MMTAG2; NbExp=3; IntAct=EBI-10268158, EBI-742459;
CC Q8N9E0; Q6ZUT1: NKAPD1; NbExp=3; IntAct=EBI-10268158, EBI-3920396;
CC Q8N9E0; O75052: NOS1AP; NbExp=3; IntAct=EBI-10268158, EBI-780467;
CC Q8N9E0; Q9NZ81: PRR13; NbExp=3; IntAct=EBI-10268158, EBI-740924;
CC Q8N9E0; Q9Y388: RBMX2; NbExp=3; IntAct=EBI-10268158, EBI-7704044;
CC Q8N9E0; Q2KHN1: RNF151; NbExp=3; IntAct=EBI-10268158, EBI-12002474;
CC Q8N9E0; Q9H190: SDCBP2; NbExp=9; IntAct=EBI-10268158, EBI-742426;
CC Q8N9E0; Q96MF2: STAC3; NbExp=6; IntAct=EBI-10268158, EBI-745680;
CC Q8N9E0; Q9NVV9: THAP1; NbExp=6; IntAct=EBI-10268158, EBI-741515;
CC Q8N9E0; P36406: TRIM23; NbExp=6; IntAct=EBI-10268158, EBI-740098;
CC -!- SIMILARITY: Belongs to the FAM133 family. {ECO:0000305}.
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DR EMBL; AK094978; BAC04467.1; -; mRNA.
DR EMBL; AL009173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113387; AAI13388.1; -; mRNA.
DR EMBL; BC113385; AAI13386.1; -; mRNA.
DR CCDS; CCDS14466.1; -.
DR RefSeq; NP_001164580.1; NM_001171109.1.
DR RefSeq; NP_001164581.1; NM_001171110.1.
DR RefSeq; NP_001164582.1; NM_001171111.1.
DR RefSeq; NP_775969.1; NM_173698.2.
DR RefSeq; XP_006724704.1; XM_006724641.3.
DR RefSeq; XP_011529227.1; XM_011530925.2.
DR RefSeq; XP_011529228.1; XM_011530926.2.
DR RefSeq; XP_011529229.1; XM_011530927.2.
DR RefSeq; XP_011529230.1; XM_011530928.1.
DR RefSeq; XP_011529231.1; XM_011530929.1.
DR RefSeq; XP_011529233.1; XM_011530931.2.
DR RefSeq; XP_016884943.1; XM_017029454.1.
DR RefSeq; XP_016884944.1; XM_017029455.1.
DR RefSeq; XP_016884945.1; XM_017029456.1.
DR AlphaFoldDB; Q8N9E0; -.
DR SMR; Q8N9E0; -.
DR BioGRID; 130395; 85.
DR IntAct; Q8N9E0; 20.
DR STRING; 9606.ENSP00000318974; -.
DR iPTMnet; Q8N9E0; -.
DR PhosphoSitePlus; Q8N9E0; -.
DR BioMuta; FAM133A; -.
DR DMDM; 74751120; -.
DR EPD; Q8N9E0; -.
DR MassIVE; Q8N9E0; -.
DR MaxQB; Q8N9E0; -.
DR PaxDb; Q8N9E0; -.
DR PeptideAtlas; Q8N9E0; -.
DR PRIDE; Q8N9E0; -.
DR ProteomicsDB; 72524; -.
DR Antibodypedia; 67595; 65 antibodies from 17 providers.
DR DNASU; 286499; -.
DR Ensembl; ENST00000322139.4; ENSP00000318974.4; ENSG00000179083.7.
DR Ensembl; ENST00000332647.5; ENSP00000362169.1; ENSG00000179083.7.
DR Ensembl; ENST00000683942.1; ENSP00000507109.1; ENSG00000179083.7.
DR GeneID; 286499; -.
DR KEGG; hsa:286499; -.
DR MANE-Select; ENST00000683942.1; ENSP00000507109.1; NM_001171109.2; NP_001164580.1.
DR UCSC; uc004efr.3; human.
DR CTD; 286499; -.
DR DisGeNET; 286499; -.
DR GeneCards; FAM133A; -.
DR HGNC; HGNC:26748; FAM133A.
DR HPA; ENSG00000179083; Tissue enhanced (brain, choroid plexus, testis).
DR neXtProt; NX_Q8N9E0; -.
DR OpenTargets; ENSG00000179083; -.
DR PharmGKB; PA162386125; -.
DR VEuPathDB; HostDB:ENSG00000179083; -.
DR eggNOG; ENOG502RXMT; Eukaryota.
DR GeneTree; ENSGT00730000111097; -.
DR HOGENOM; CLU_108741_0_0_1; -.
DR InParanoid; Q8N9E0; -.
DR OMA; KEKCIRS; -.
DR OrthoDB; 1561261at2759; -.
DR PhylomeDB; Q8N9E0; -.
DR TreeFam; TF350193; -.
DR PathwayCommons; Q8N9E0; -.
DR SignaLink; Q8N9E0; -.
DR BioGRID-ORCS; 286499; 47 hits in 684 CRISPR screens.
DR GenomeRNAi; 286499; -.
DR Pharos; Q8N9E0; Tbio.
DR PRO; PR:Q8N9E0; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8N9E0; protein.
DR Bgee; ENSG00000179083; Expressed in buccal mucosa cell and 100 other tissues.
DR Genevisible; Q8N9E0; HS.
DR InterPro; IPR026766; Fam133.
DR PANTHER; PTHR31911; PTHR31911; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..248
FT /note="Protein FAM133A"
FT /id="PRO_0000287619"
FT REGION 68..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..248
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 67
FT /note="E -> K (in dbSNP:rs34123774)"
FT /id="VAR_053907"
SQ SEQUENCE 248 AA; 28941 MW; DB18B8F3FABFBAF6 CRC64;
MGKRDNRVAY MNPIAMARWR GPTQSVGPTI QDYLNRPRPT WEEVKKQLEN KKTGSKALAE
FEEKMNENWK KELEKSREKL LSGNESSSKK RERKKKRKKK SCRSSSSSSS SDSSSSSSDS
EDEEKKQGKR RKKKKNRSYK SSQSSTHESE SESKESVKKK KKSKDETEKE KDVRSLSKKR
KKSYPDDKPL SSESSSESDY EEDVQAKKKR RCEEREQAKE KVKKKKKKQH KKHSKKKKKK
SGSSHKSR
