F133B_MOUSE
ID F133B_MOUSE Reviewed; 245 AA.
AC Q9CVI2; B2RVR0; Q78HY5;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein FAM133B;
GN Name=Fam133b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-127 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Small intestine, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 171-179, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CVI2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CVI2-2; Sequence=VSP_025572, VSP_025573;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM133 family. {ECO:0000305}.
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DR EMBL; AK008115; BAB25470.1; -; mRNA.
DR EMBL; AK161505; BAE36429.1; -; mRNA.
DR EMBL; AC090443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC147310; AAI47311.1; -; mRNA.
DR EMBL; BC147311; AAI47312.1; -; mRNA.
DR EMBL; BC027051; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS39000.1; -. [Q9CVI2-1]
DR RefSeq; NP_001035966.1; NM_001042501.1. [Q9CVI2-1]
DR AlphaFoldDB; Q9CVI2; -.
DR SMR; Q9CVI2; -.
DR BioGRID; 212685; 1.
DR STRING; 10090.ENSMUSP00000111189; -.
DR iPTMnet; Q9CVI2; -.
DR PhosphoSitePlus; Q9CVI2; -.
DR EPD; Q9CVI2; -.
DR MaxQB; Q9CVI2; -.
DR PaxDb; Q9CVI2; -.
DR PeptideAtlas; Q9CVI2; -.
DR PRIDE; Q9CVI2; -.
DR ProteomicsDB; 275564; -. [Q9CVI2-1]
DR ProteomicsDB; 275565; -. [Q9CVI2-2]
DR Antibodypedia; 58077; 36 antibodies from 11 providers.
DR Ensembl; ENSMUST00000115527; ENSMUSP00000111189; ENSMUSG00000058503. [Q9CVI2-1]
DR GeneID; 68152; -.
DR KEGG; mmu:68152; -.
DR UCSC; uc008wgx.1; mouse. [Q9CVI2-2]
DR UCSC; uc008wgy.1; mouse. [Q9CVI2-1]
DR CTD; 257415; -.
DR MGI; MGI:1915402; Fam133b.
DR VEuPathDB; HostDB:ENSMUSG00000058503; -.
DR eggNOG; ENOG502QWN4; Eukaryota.
DR GeneTree; ENSGT00730000111097; -.
DR InParanoid; Q9CVI2; -.
DR OMA; DKINRES; -.
DR OrthoDB; 1561261at2759; -.
DR PhylomeDB; Q9CVI2; -.
DR TreeFam; TF350193; -.
DR BioGRID-ORCS; 68152; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Fam133b; mouse.
DR PRO; PR:Q9CVI2; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CVI2; protein.
DR Bgee; ENSMUSG00000058503; Expressed in dorsal pancreas and 247 other tissues.
DR ExpressionAtlas; Q9CVI2; baseline and differential.
DR Genevisible; Q9CVI2; MM.
DR InterPro; IPR026766; Fam133.
DR PANTHER; PTHR31911; PTHR31911; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..245
FT /note="Protein FAM133B"
FT /id="PRO_0000287617"
FT REGION 19..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 69..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..236
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 82
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5BKY9"
FT MOD_RES 190
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5BKY9"
FT MOD_RES 191
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5BKY9"
FT MOD_RES 193
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5BKY9"
FT MOD_RES 195
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5BKY9"
FT VAR_SEQ 104..115
FT /note="YSSSSSSSSDSS -> VSKSFLFSKCYS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_025572"
FT VAR_SEQ 116..245
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_025573"
FT CONFLICT 81
FT /note="L -> I (in Ref. 1; BAB25470)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 245 AA; 27952 MW; F816A4DFC6AFB88B CRC64;
MGKRDNRVAY MNPIAMARSR GPIQSSGPTI QDYLNRPRPT WEEVKEQLEK KKKGSKALAE
FEEKMNENWK KELEKHREKL LSGNESSSKK RQKKKKEKKK SGRYSSSSSS SSDSSSSSSD
SEDEDKKQTK RRKKKKSRCH KSPESSGSDS ASDSKDGSKK KKKSKDVTER EKDTKGLSKK
RKMYEDKPLS SESLSESDCG EVQAKRKKSG EERERTTDKA KKRRKHKKHS KKKKKKAASS
SSDSP
