F135A_MOUSE
ID F135A_MOUSE Reviewed; 1506 AA.
AC Q6NS59; Q3UEW1; Q5XK31; Q8BXS8; Q8BZL9; Q8K2K2; Q9D2J6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein FAM135A;
GN Name=Fam135a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-479 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Diencephalon, Retina, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Embryo, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NS59-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NS59-2; Sequence=VSP_030231;
CC -!- SIMILARITY: Belongs to the FAM135 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH83093.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK019549; BAB31792.2; -; mRNA.
DR EMBL; AK034175; BAC28616.1; -; mRNA.
DR EMBL; AK044359; BAC31883.1; -; mRNA.
DR EMBL; AK149303; BAE28800.1; -; mRNA.
DR EMBL; BC031160; AAH31160.1; -; mRNA.
DR EMBL; BC070446; AAH70446.1; -; mRNA.
DR EMBL; BC083093; AAH83093.1; ALT_INIT; mRNA.
DR CCDS; CCDS14853.1; -. [Q6NS59-1]
DR RefSeq; NP_080880.4; NM_026604.4. [Q6NS59-1]
DR RefSeq; XP_017177767.1; XM_017322278.1.
DR AlphaFoldDB; Q6NS59; -.
DR STRING; 10090.ENSMUSP00000027337; -.
DR ESTHER; mouse-F135A; Duf_676.
DR CarbonylDB; Q6NS59; -.
DR iPTMnet; Q6NS59; -.
DR PhosphoSitePlus; Q6NS59; -.
DR jPOST; Q6NS59; -.
DR MaxQB; Q6NS59; -.
DR PaxDb; Q6NS59; -.
DR PeptideAtlas; Q6NS59; -.
DR PRIDE; Q6NS59; -.
DR ProteomicsDB; 271518; -. [Q6NS59-1]
DR ProteomicsDB; 271519; -. [Q6NS59-2]
DR Antibodypedia; 31231; 23 antibodies from 9 providers.
DR Ensembl; ENSMUST00000027337; ENSMUSP00000027337; ENSMUSG00000026153. [Q6NS59-1]
DR GeneID; 68187; -.
DR KEGG; mmu:68187; -.
DR UCSC; uc007amk.2; mouse. [Q6NS59-1]
DR CTD; 57579; -.
DR MGI; MGI:1915437; Fam135a.
DR VEuPathDB; HostDB:ENSMUSG00000026153; -.
DR eggNOG; KOG2205; Eukaryota.
DR GeneTree; ENSGT00940000157565; -.
DR InParanoid; Q6NS59; -.
DR OMA; VESHCTE; -.
DR OrthoDB; 1132320at2759; -.
DR PhylomeDB; Q6NS59; -.
DR TreeFam; TF314837; -.
DR Reactome; R-MMU-9696273; RND1 GTPase cycle.
DR BioGRID-ORCS; 68187; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Fam135a; mouse.
DR PRO; PR:Q6NS59; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q6NS59; protein.
DR Bgee; ENSMUSG00000026153; Expressed in manus and 215 other tissues.
DR ExpressionAtlas; Q6NS59; baseline and differential.
DR Genevisible; Q6NS59; MM.
DR GO; GO:0044255; P:cellular lipid metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR022122; DUF3657.
DR InterPro; IPR007751; DUF676_lipase-like.
DR InterPro; IPR044294; Lipase-like.
DR PANTHER; PTHR12482; PTHR12482; 1.
DR Pfam; PF12394; DUF3657; 1.
DR Pfam; PF05057; DUF676; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..1506
FT /note="Protein FAM135A"
FT /id="PRO_0000314169"
FT REGION 536..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..592
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..425
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030231"
FT CONFLICT 486
FT /note="E -> D (in Ref. 1; BAC31883)"
FT /evidence="ECO:0000305"
FT CONFLICT 703
FT /note="D -> Y (in Ref. 2; AAH70446)"
FT /evidence="ECO:0000305"
FT CONFLICT 754
FT /note="K -> N (in Ref. 1; BAB31792)"
FT /evidence="ECO:0000305"
FT CONFLICT 813
FT /note="H -> R (in Ref. 1; BAB31792)"
FT /evidence="ECO:0000305"
FT CONFLICT 994
FT /note="D -> E (in Ref. 1; BAC28616)"
FT /evidence="ECO:0000305"
FT CONFLICT 1044
FT /note="T -> A (in Ref. 2; AAH83093)"
FT /evidence="ECO:0000305"
FT CONFLICT 1162
FT /note="R -> K (in Ref. 1; BAB31792)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1506 AA; 166857 MW; 5428467DDF228796 CRC64;
MTEVQAMVEF SVELNKFYNV DLFQRGFYQI RASMKIPARI PHRVEASLLH ATGMTLAFPA
SVHDALVCSK TFQILYKNEE VVLNDVMIFK VKMLLDERKI EETLEEISFL LSLGLHFTDG
DYSADDLNAL QLISSRTLKL HYSICRGLHH HANVMFDYFH LSVVSVTVHA SLVALHQPLI
SFPRPVKTTW LNRNAPAQSK DSAIPTLESV VFGINYTKQL SPDGCSFLIA ESFLHHAYHF
HYTLCATLLL AFKGLHSYFI TVTEEIPSCQ KLDLEEMDVE ARLTELCEEV KKVENPDELA
ELINMNLAQL CSLLMALWGQ FLEAITLHED LRVLLAQEHH TLRVRRFSEA FFCFEHPREA
AIAYQELHAQ SHLQMCTAIK NTSFCSSLPP LPIECSELDG DLNSLPIIFE DRYLDSVIED
LDAPWMGIQS LQISEASKTD KHETEESSVV GLSSPELKVR PAVASSNCYT EGEKQLTKSL
KGKNEESNKS KVKVTKLMKT MKPENTKKLI KQNSKDSVVL VSYKCLKTTA SSDFTKCLEG
SPSHSQKEGL DPTLCAGNFD PKTYTRQPSQ KEASSLSANT DRSEHKSPDT ENMQPDQFEL
LNSGSLNLCA NLSISGKLAI SQDNSDIPDT EHNLASTSSS NDCHDYQTTP SSGVRTLEVK
SSSKESFNGE KITVKIGPWT ELQEAELFVD NLLPDFEALD SNDKPKSIDI PLERDALQET
KCHSTEESLT KFRSNLPAPS TKEYHVAVSS DTIKLPDTNA TYASSRFSDS GVESEPSSFA
THPNPEIAFE TLQGPGPCNN ERLFPQLLMK PDHNVKFSLG SHCTESTSAL SEIQSSLTSI
NSLPSDDELS PDDNCKKSAV PDCHLSDSKT VFNLGTMDLP KCDDTKKSSI ILQQQSVVFS
GHLDNDTLAM HSLDLSTEDP LRLVFLDEDA SSGVRSSWGS KPHLDAPFTG PQSQGTSSNN
STESVPTLNS KLICLGSPCV VSGSVCTDAG LSADRTVEGK SGEPLNHKQV CSAAPVVESD
PLSSSTDVVK QGLVENYFGS QSTTDVSDAC AITCHSPVSS QETCDKGISD LQQEQGKEEE
EEDQEMVQNG YHEETDFSAT DGTVSVHYIS GNELGEGRHE QSEKLSSNYL SAGVTVPAVC
TSGCLSFPSA LRESPCVKYS SRSKVDAITK QPSSISYNFS SSTSWYENSP KPQIHAFLQA
KEELKQLRLP GFMYSDVPLL ASSAPYFSMD EEDGSEDGVH LIVCVHGLDG NSADLRLVKT
YIELGLPGGR VDFLMSERNQ NDTFADFDCM TDRLLDEIIQ YIQIYSLTVS KISFIGHSLG
NLIIRSVLTR PRFKYYLSKL HTFLSLSGPH LGTLYNSSAL VNTGLWFMQK WKKSGSLLQL
TCRDHSDPRQ TFLYKLSNKA GLHYFKNVVL VGSLQDRYVP YHSARIEMCK TALKDKQSGQ
IYSEMIHNLL RPVLQSKGCN LVRYNVINAL PNTADSLIGR AAHIAVLDSE IFLEKFFLVA
ALKYFQ
