AHL8_ARATH
ID AHL8_ARATH Reviewed; 386 AA.
AC Q9FIR1;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=AT-hook motif nuclear-localized protein 8 {ECO:0000312|EMBL:FAA00279.1};
GN Name=AHL8 {ECO:0000303|PubMed:15604740};
GN OrderedLocusNames=At5g46640 {ECO:0000312|Araport:AT5G46640};
GN ORFNames=MZA15.3 {ECO:0000312|EMBL:BAB08908.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=15604740; DOI=10.1007/s11103-004-3249-5;
RA Fujimoto S., Matsunaga S., Yonemura M., Uchiyama S., Azuma T., Fukui K.;
RT "Identification of a novel plant MAR DNA binding protein localized on
RT chromosomal surfaces.";
RL Plant Mol. Biol. 56:225-239(2004).
RN [6]
RP GENE FAMILY, AND DOMAIN PPC.
RX PubMed=24218605; DOI=10.1073/pnas.1219277110;
RA Zhao J., Favero D.S., Peng H., Neff M.M.;
RT "Arabidopsis thaliana AHL family modulates hypocotyl growth redundantly by
RT interacting with each other via the PPC/DUF296 domain.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:E4688-E4697(2013).
CC -!- FUNCTION: Transcription factor that specifically binds AT-rich DNA
CC sequences related to the nuclear matrix attachment regions (MARs).
CC {ECO:0000250|UniProtKB:Q8VYJ2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VYJ2}.
CC -!- DOMAIN: The PPC domain mediates interactions between AHL proteins.
CC {ECO:0000269|PubMed:24218605}.
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DR EMBL; AB016882; BAB08908.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95409.1; -; Genomic_DNA.
DR EMBL; BT015318; AAT99797.1; -; mRNA.
DR EMBL; BT015755; AAU84692.1; -; mRNA.
DR EMBL; AB493779; BAH30617.1; -; mRNA.
DR EMBL; BR000344; FAA00279.1; -; mRNA.
DR RefSeq; NP_199476.1; NM_124034.4.
DR AlphaFoldDB; Q9FIR1; -.
DR SMR; Q9FIR1; -.
DR STRING; 3702.AT5G46640.1; -.
DR iPTMnet; Q9FIR1; -.
DR PaxDb; Q9FIR1; -.
DR PRIDE; Q9FIR1; -.
DR ProteomicsDB; 244719; -.
DR EnsemblPlants; AT5G46640.1; AT5G46640.1; AT5G46640.
DR GeneID; 834707; -.
DR Gramene; AT5G46640.1; AT5G46640.1; AT5G46640.
DR KEGG; ath:AT5G46640; -.
DR Araport; AT5G46640; -.
DR TAIR; locus:2178505; AT5G46640.
DR eggNOG; ENOG502R1P2; Eukaryota.
DR HOGENOM; CLU_039808_7_2_1; -.
DR InParanoid; Q9FIR1; -.
DR OMA; IPTHSAN; -.
DR OrthoDB; 1160056at2759; -.
DR PhylomeDB; Q9FIR1; -.
DR PRO; PR:Q9FIR1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FIR1; baseline and differential.
DR Genevisible; Q9FIR1; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IEA:InterPro.
DR CDD; cd11378; DUF296; 1.
DR InterPro; IPR039605; AHL.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR005175; PPC_dom.
DR PANTHER; PTHR31500; PTHR31500; 1.
DR Pfam; PF03479; PCC; 1.
DR SMART; SM00384; AT_hook; 2.
DR PROSITE; PS51742; PPC; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..386
FT /note="AT-hook motif nuclear-localized protein 8"
FT /id="PRO_0000432026"
FT DOMAIN 174..316
FT /note="PPC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01078"
FT DNA_BIND 102..114
FT /note="A.T hook 1"
FT /evidence="ECO:0000255"
FT DNA_BIND 155..167
FT /note="A.T hook 2"
FT /evidence="ECO:0000255"
FT REGION 1..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 102..110
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000305"
FT COMPBIAS 32..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 386 AA; 40834 MW; 9089978C64DDC2AC CRC64;
MDSRDIPPSH NQLQPPPGML MSHYRNPNAA ASPLMVPTST SQPIQHPRLP FGNQQQSQTF
HQQQQQQMDQ KTLESLGFGD GSPSSQPMRF GIDDQNQQLQ VKKKRGRPRK YTPDGSIALG
LAPTSPLLSA ASNSYGEGGV GDSGGNGNSV DPPVKRNRGR PPGSSKKQLD ALGGTSGVGF
TPHVIEVNTG EDIASKVMAF SDQGSRTICI LSASGAVSRV MLRQASHSSG IVTYEGRFEI
ITLSGSVLNY EVNGSTNRSG NLSVALAGPD GGIVGGSVVG NLVAATQVQV IVGSFVAEAK
KPKQSSVNIA RGQNPEPASA PANMLNFGSV SQGPSSESSE ENESGSPAMH RDNNNGIYGA
QQQQQQQPLH PHQMQMYQHL WSNHGQ
