F135B_MOUSE
ID F135B_MOUSE Reviewed; 1403 AA.
AC Q9DAI6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 3.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein FAM135B;
GN Name=Fam135b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 982-1403.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 982-1403.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-775 AND SER-776, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the FAM135 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI19175.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB24252.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC125528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC157277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC157602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK005816; BAB24252.2; ALT_INIT; mRNA.
DR EMBL; BC119174; AAI19175.1; ALT_INIT; mRNA.
DR CCDS; CCDS49626.1; -.
DR RefSeq; NP_808487.2; NM_177819.3.
DR RefSeq; XP_006521456.1; XM_006521393.3.
DR RefSeq; XP_006521458.1; XM_006521395.2.
DR AlphaFoldDB; Q9DAI6; -.
DR STRING; 10090.ENSMUSP00000022953; -.
DR ESTHER; mouse-Q9DAI6; Duf_676.
DR iPTMnet; Q9DAI6; -.
DR PhosphoSitePlus; Q9DAI6; -.
DR EPD; Q9DAI6; -.
DR MaxQB; Q9DAI6; -.
DR PaxDb; Q9DAI6; -.
DR PRIDE; Q9DAI6; -.
DR ProteomicsDB; 275566; -.
DR Antibodypedia; 14311; 117 antibodies from 18 providers.
DR DNASU; 70363; -.
DR Ensembl; ENSMUST00000022953; ENSMUSP00000022953; ENSMUSG00000036800.
DR GeneID; 70363; -.
DR KEGG; mmu:70363; -.
DR UCSC; uc011ztr.1; mouse.
DR CTD; 51059; -.
DR MGI; MGI:1917613; Fam135b.
DR VEuPathDB; HostDB:ENSMUSG00000036800; -.
DR eggNOG; KOG2205; Eukaryota.
DR GeneTree; ENSGT00940000156079; -.
DR HOGENOM; CLU_003176_0_0_1; -.
DR InParanoid; Q9DAI6; -.
DR OMA; PRKGLHH; -.
DR OrthoDB; 1132320at2759; -.
DR PhylomeDB; Q9DAI6; -.
DR TreeFam; TF314837; -.
DR BioGRID-ORCS; 70363; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Fam135b; mouse.
DR PRO; PR:Q9DAI6; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9DAI6; protein.
DR Bgee; ENSMUSG00000036800; Expressed in spermatid and 34 other tissues.
DR ExpressionAtlas; Q9DAI6; baseline and differential.
DR Genevisible; Q9DAI6; MM.
DR GO; GO:0044255; P:cellular lipid metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR022122; DUF3657.
DR InterPro; IPR007751; DUF676_lipase-like.
DR InterPro; IPR044294; Lipase-like.
DR PANTHER; PTHR12482; PTHR12482; 1.
DR Pfam; PF12394; DUF3657; 1.
DR Pfam; PF05057; DUF676; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..1403
FT /note="Protein FAM135B"
FT /id="PRO_0000314172"
FT REGION 445..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 775
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 776
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 1403 AA; 155524 MW; FD949E39FEDF060B CRC64;
MSEVQGTVEF SVELHKFYNV DLFQRGYYQI RVTLKVSSRI PHRLSASIVG QSESSSLHSA
CVHESAVHSR VFQILYRNEE VSINDAMLFR VHLLLDGERV EDALSEVEFQ LKVDLHFTDS
EQQLRDVTGT PMISSRTLGL HFHPRRGLHH QVPVMFDYFH LSVISVAIHA ALVALQQPLI
SFTRPGRGSW LGKGGPDTGP EQPTISLENL VFGAGYCKPT SSEGSFYVPS ENCIQHAHKW
HRDLCLLLLH AYQGLRLYFL VIMRDIPELP TMELEALAVE ETLSQLCSEL QMLNNPEKIA
EQISKDLAWL ASHLMALWTQ FLDTVTLHSQ VTTYLTQEHH TLRVRRFSEA FFYMEHQKLA
VLTFQENLIQ THSQLSLDIR NSEYLTSMPP LPAECLDIDG DWNTLPVIFE DRYVDCPVSG
HNLSVYPNFD VPVTSPAIMN LKGKEKNLIN QNSSSRKDIP LSTTEAPQLG SDEDVTRRPE
VQENVSTWNP IDVCSESQVY LTIGEFQNRA GIPEDECWTG PRPDAVKDSL TDTDICSRSP
GPDEGQTPAL TYIDVQSSNK YCPRAELVQG INVQHEHRSS RESYGIVKTV PSKVVAGTSQ
NNSTSLNQTA ALELRTLGRG VNQDGKPVLL SLKLTPAEPC DPPSTALREA LDTKPSQPDH
AEEPEDLSAL SGVIKRSASI ISDSGIESEP SSVAWSEARS RALELPSDRD VLHQVVRRHA
HHRNSLEGGH TESNTSLPSG IQASLSSISS LPFEEEEREL ALNKLTKSVS APQISSPEES
AEGADTIKNT AGFSEDLDPS SKENSPPRHT SLSYGGSRVQ DVRAGHSLAD IALDSDRPQG
PGYMDIPNDK GNHPELQEPC CLDGMAETPL HVETKGLNLK IPCTIVLENS KSRSFHRAAG
ETAKGKPEEL SMSKCVLSNN SISEVRAASH HRVPEISCSP AVEAVNLNST GVQNSSLSVN
DTMTLNRRHN ASLEAKHEAG TVCPTVTHTI ASQVSRNQEL KTGTSISGSH LNSTEAFTLD
SLKAVEVVNL SVSCTATCLP FSSVPKETPA RAGLSSKQNP APITHQPLGS FGVVSTYSSK
LEEEVSERMF SFYQAKEKFK KELKIEGFLY SDLSVLASDI PYFPPEEEEE NLEDGIHLVV
CVHGLDGNSA DLRLVKTFIE LGLPGGKLDF LMSEKNQTDT FADFDTMTDR LLDEIIQHIQ
LYNLSISRIS FIGHSLGNII IRSVLTRPRF RYYLNKLHTF LSLSGPHLGT LYNNSTLVST
GLWLMQKLKK SGSLLQLTFR DNADLRKCFL YQLSQKTGLQ YFKNVVLVAS PQDRYVPFHS
ARIEMCKTAL KDRHTGPVYA EMINNLLGPL VEAKDCTLIR HNVFHALPNT ANTLIGRAAH
IAVLDSELFL EKFFLVAGLN YFK
