F136A_HUMAN
ID F136A_HUMAN Reviewed; 138 AA.
AC Q96C01; Q96SS3;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Protein FAM136A;
GN Name=FAM136A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- INTERACTION:
CC Q96C01; X5D778: ANKRD11; NbExp=3; IntAct=EBI-373319, EBI-17183751;
CC Q96C01; Q9C005: DPY30; NbExp=3; IntAct=EBI-373319, EBI-744973;
CC Q96C01; O15481: MAGEB4; NbExp=3; IntAct=EBI-373319, EBI-751857;
CC Q96C01; O95983-2: MBD3; NbExp=3; IntAct=EBI-373319, EBI-11978579;
CC Q96C01; O14770-4: MEIS2; NbExp=3; IntAct=EBI-373319, EBI-8025850;
CC Q96C01; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-373319, EBI-741158;
CC Q96C01; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-373319, EBI-10181968;
CC Q96C01; P20618: PSMB1; NbExp=3; IntAct=EBI-373319, EBI-372273;
CC Q96C01; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-373319, EBI-11984663;
CC Q96C01; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-373319, EBI-358489;
CC Q96C01; Q6DKK2: TTC19; NbExp=3; IntAct=EBI-373319, EBI-948354;
CC -!- SIMILARITY: Belongs to the FAM136 family. {ECO:0000305}.
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DR EMBL; AK027574; BAB55208.1; -; mRNA.
DR EMBL; AC022201; AAX93110.1; -; Genomic_DNA.
DR EMBL; BC014975; AAH14975.1; -; mRNA.
DR CCDS; CCDS1904.1; -.
DR RefSeq; NP_116211.2; NM_032822.2.
DR AlphaFoldDB; Q96C01; -.
DR SMR; Q96C01; -.
DR BioGRID; 124345; 104.
DR IntAct; Q96C01; 82.
DR MINT; Q96C01; -.
DR STRING; 9606.ENSP00000037869; -.
DR GlyGen; Q96C01; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96C01; -.
DR MetOSite; Q96C01; -.
DR PhosphoSitePlus; Q96C01; -.
DR BioMuta; FAM136A; -.
DR DMDM; 74751785; -.
DR EPD; Q96C01; -.
DR jPOST; Q96C01; -.
DR MassIVE; Q96C01; -.
DR MaxQB; Q96C01; -.
DR PaxDb; Q96C01; -.
DR PeptideAtlas; Q96C01; -.
DR PRIDE; Q96C01; -.
DR ProteomicsDB; 76138; -.
DR Antibodypedia; 31110; 52 antibodies from 12 providers.
DR DNASU; 84908; -.
DR Ensembl; ENST00000037869.7; ENSP00000037869.3; ENSG00000035141.8.
DR GeneID; 84908; -.
DR KEGG; hsa:84908; -.
DR UCSC; uc002sgq.5; human.
DR CTD; 84908; -.
DR DisGeNET; 84908; -.
DR GeneCards; FAM136A; -.
DR HGNC; HGNC:25911; FAM136A.
DR HPA; ENSG00000035141; Low tissue specificity.
DR MalaCards; FAM136A; -.
DR MIM; 616275; gene.
DR neXtProt; NX_Q96C01; -.
DR OpenTargets; ENSG00000035141; -.
DR PharmGKB; PA162386322; -.
DR VEuPathDB; HostDB:ENSG00000035141; -.
DR eggNOG; KOG3377; Eukaryota.
DR GeneTree; ENSGT00390000006707; -.
DR HOGENOM; CLU_110442_3_0_1; -.
DR InParanoid; Q96C01; -.
DR PhylomeDB; Q96C01; -.
DR TreeFam; TF315119; -.
DR PathwayCommons; Q96C01; -.
DR SignaLink; Q96C01; -.
DR BioGRID-ORCS; 84908; 298 hits in 1083 CRISPR screens.
DR ChiTaRS; FAM136A; human.
DR GeneWiki; FAM136A; -.
DR GenomeRNAi; 84908; -.
DR Pharos; Q96C01; Tdark.
DR PRO; PR:Q96C01; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96C01; protein.
DR Bgee; ENSG00000035141; Expressed in parotid gland and 206 other tissues.
DR ExpressionAtlas; Q96C01; baseline and differential.
DR Genevisible; Q96C01; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:LIFEdb.
DR InterPro; IPR008560; DUF842_euk.
DR PANTHER; PTHR21096; PTHR21096; 1.
DR Pfam; PF05811; DUF842; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330"
FT CHAIN 2..138
FT /note="Protein FAM136A"
FT /id="PRO_0000296950"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:19413330"
FT MOD_RES 124
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:B0BN94"
FT MOD_RES 126
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:B0BN94"
FT CONFLICT 13
FT /note="V -> M (in Ref. 1; BAB55208)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 138 AA; 15641 MW; 72D3CA33B937F8B7 CRC64;
MAELQQLRVQ EAVESMVKSL ERENIRKMQG LMFRCSASCC EDSQASMKQV HQCIERCHVP
LAQAQALVTS ELEKFQDRLA RCTMHCNDKA KDSIDAGSKE LQVKQQLDSC VTKCVDDHMH
LIPTMTKKMK EALLSIGK
